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Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOFÁRMACOS
49 Resultados
Solicitudes de Patente publicadas a nivel mundial en los últimos 30 dias.
Datos actualizados a 05/01/2016 [14:53:00]
Compound fructus forsythiae-radix bupleuri oil nanoemulsion and preparation method
Nº publicación EP2959911A1 30/12/2015
ZHANG XIAOYAN¿[CN]
Solicitantes
The invention discloses a compound fructus forsythiae-radix bupleuri oil nanoemulsion, wherein the grain sizes of the liquid
Resumen
drops of the nanoemulsion range from 10 to 100 nm; and the nanoemulsion is prepared from the raw materials in the following
percentage by weight: 12.00-28.00% of a surfactant, 15.00-30.00% of a cosurfactant, 3.00-8.00% of oil, 0.10-5.00% of fructus
forsythiae oil, 0.10-5.00% of radix bupleuri oil, 0.01-0.05% of vitamin C, 0.01-0.05% of vitamin B, and 20.00-68.4% of distilled
water, wherein the total percentage of the components is 100%. According to the compound fructus forsythiae-radix bupleuri oil
nanoemulsion, the medicine stability of a fructus forsythiae oil and radix bupleuri oil mixture during a processing process can be
improved, the bioavailability can be improved, the medicine metabolism time in a body can be delayed, the dosage of auxiliary
materials can be reduced, and the production cost can be decreased; the compound fructus forsythiae-radix bupleuri oil
nanoemulsion has a wide market prospect in the field of medicines.
CAGED PLATINUM NANOCLUSTERS FOR ANTICANCER CHEMOTHERAPEUTICS
Nº publicación EP2958553A2 30/12/2015
NAT HEALTH RESEARCH INSTITUTES¿[TW]
Solicitantes
A caged platinum nanocluster complex is disclosed. The complex
Resumen
comprises (a) an amine-terminated dendrimer; and (b) a platinum
nanocluster comprising platinum oxides, the platinum nanocluster
being confined inside of the amine-terminated dendrimer. The
complex exhibits cytotoxicity to cancer cells. A double-caged
platinum nanocluster complex is also disclosed, which comprises
polyethylene glycol (PEG) coated on the surface of a dendrimer caged
platinum nanocluster complex. The double-caged caged platinum
nanocluster complex comprises pH-sensitive bonds on the surface
thereof. Also disclosed are methods of preparing and using the same.
Alertas Tecnológicas
- 1 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
ACTIVATION OF INKT CELLS
Nº publicación EP2958595A1 30/12/2015
INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE¿[FR]
Solicitantes
CENTRE NAT RECH SCIENT¿[FR]
UNIV LILLE 2 UNIVERSITÉ DU DROIT ET DE LA SANTÉ¿[FR]
UNIV LEIDEN MEDICAL CT¿[NL]
PASTEUR INSTITUT¿[FR]
The present invention relates to particulate entity, such as a
Resumen
nanoparticle or conjugate, for use in particular as adjuvant in vaccine
or immunotherapy. More specifically, the invention relates to a
particulate entity comprising: iv. an iNKT cell agonist such as [alpha]
Gal Car compound, and, v. one or more antigenic determinant(s) such
as a tumour antigen(s) or pathogen-derived antigen(s), vi. a targeting
agent that targets in vivo said iNKT cell agonist to dendritic cells,
such as human BDCA3+ dendritic cells.
Alertas Tecnológicas
- 2 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
TARGETED BUCCAL DELIVERY OF AGENTS
Nº publicación EP2958555A2 30/12/2015
MASSACHUSETTS INST TECHNOLOGY¿[US]
Solicitantes
A delivery device for topical and systemic delivery of agents to
Resumen
targeted oral locations, such as mouth cancer cells, has been
developed. The formulation includes a mucoadhesive polymeric
matrix such as chitosan, which contains one or more therapeutic
and/or diagnostic agents, taste masking agents, permeation enhancers,
the therapeutic or diagnostic agent to be delivered, and a hydrophilic
polymeric coating such as polyethyleneglycol ("PEG").
COMPOSITIONS AND METHODS FOR USE IN MEDICAL DIAGNOSIS
Nº publicación AU2014283217A1 24/12/2015
NANOBIOTIX
Solicitantes
The present invention relates to compositions and methods for use in
Resumen
medical diagnosis and patient's monitoring. It more particularly relates
to a biocompatible gel comprising nanoparticles and/or nanoparticles
aggregates, wherein i) the nanoparticle and/or nanoparticles aggregate
comprise an inorganic material comprising at least one metal element
having an atomic number Z of at least 25, each of said nanoparticle
and of said nanoparticles aggregate being covered with a
biocompatible coating; ii) the nanoparticles and/or nanoparticles
aggregates concentration is of about or less than 0.5% (w/w); and iii)
the apparent viscosity at 2s - of the gel comprising nanoparticles
and/or nanoparticles aggregates, is between about 0.1 Pa.s and about
1000 Pa.s when measured between 20 DEG C and 37 DEG C. 1 The
composition of the invention typically allows the delineation and
visualization of at least 40% of the target biological tissue when said
tissue is observed using an X-ray imaging equipment.
Alertas Tecnológicas
- 3 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
UREA DERIVATIVES AND USES THEREOF
Nº publicación AU2014278231A1 24/12/2015
NGUYEN MINH
Solicitantes
KIM JINSOO
KALA PHARMACEUTICALS INC
ENLOW ELIZABETH
The present invention provides novel compounds of any one of
Resumen
Formulae (I)-(III), and pharmaceutical compositions thereof. Also
provided are particles (e.g., nanoparticles) comprising compounds of
Formula (I)-(III) and pharmaceutical compositions thereof that are
mucus penetrating. The invention also provides methods and kits for
using the inventive compounds, and pharmaceutical compositions
thereof, for treating and/or preventing diseases associated with
abnormal or pathological angiogenesis and/or aberrant signaling of a
growth factor (e.g., vascular endothelial growth factor (VEGF)), such
as proliferative diseases (e.g., cancers, benign neoplasms,
inflammatory diseases, autoimmune diseases) and ocular diseases
(e.g., macular degeneration, glaucoma, diabetic retinopathy,
retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical
inflammation) in a subject in need thereof.
COATED PARTICLES AND COMPOSITIONS COMPRISING SAME
Nº publicación AU2014276460A1 24/12/2015
VYOME BIOSCIENCES PVT LTD
Solicitantes
The invention provides species of lipid, protein, and/or cationic
Resumen
molecule coated active agents and compositions comprising the coated
particles. The compositions can be personal care compositions such as
anti-dandruff shampoo or conditioner, skin care compositions, creams,
gels, toothpastes, mouth washes, and chewing gums.
Alertas Tecnológicas
- 4 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
FLUORESCENT SOLID LIPID NANOPARTICLES COMPOSITION AND PREPARATION THEREOF
Nº publicación AU2014273118A1 24/12/2015
BRACCO IMAGING SPA
Solicitantes
The present invention discloses a solid lipid nanoparticle (SLN)
Resumen
comprising: a) a solid lipid core comprising at least a glyceride and/or
at least a fatty acid; b) a mixture of amphiphilic components forming a
shell around said core a); c) an alkaline-earth complex with a
compound of formula I and/or II: d) at least a fluorescent dye selected
from: a cyanine fluorescent dye and /or a polyetherocyclic compound
selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole
and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged
blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from
degradation and improves the fluorescent quantum yield.
NANOPARTICLE DELIVERY COMPOSITIONS
Nº publicación EP2956119A1 23/12/2015
MIDATECH LTD¿[GB]
Solicitantes
Nanoparticle delivery systems for use in targeting biologically active
Resumen
agents to the central nervous system comprise a composition
comprising (a) a nanoparticle comprising: (i) a core comprising a
metal and/or a semiconductor; and (ii) a corona comprising a plurality
of ligands covalently linked to the core, wherein said ligands comprise
a carbohydrate, insulin and/or a glutathione; and (b) the at least one
agent to be delivered to the CNS. Methods of treatment and
diagnosing CNS disorders utilising the nanoparticle delivery systems
and related screening methods are also disclosed.
Alertas Tecnológicas
- 5 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
SUPRAMOLECULAR MAGNETIC NANOPARTICLES
Nº publicación EP2956122A1 23/12/2015
UNIV CALIFORNIA¿[US]
Solicitantes
RES AFFAIRS UIF YONSEI UNIVERSITY OFF OF¿[KR]
A supramolecular magnetic nanoparticle (SMNP) can be formed by
Resumen
self-assembly of structural components, binding components,
terminating components and at least one magnetic nanoparticle. The
SMNP can provide on-demand release of a cargo and act as part of an
on-demand drug release system.
NANOPARTICULATE COMPLEX OF NICOTINE AND CERIUM OXIDE AND USE THEREOF
Nº publicación WO2015191707A2 17/12/2015
US HEALTH¿[US]
Solicitantes
Disclosed are particles comprising a complex of nicotine and cerium oxide and a biodegradable coating comprising agglutinin.
Resumen
Also disclosed is a method of treating or preventing neurodegenerative or neurological disorders in a mammal in need thereof,
comprising administering to the mammal a therapeutically effective amount of the particles.
SELF-ASSEMBLING STRUCTURES
Nº publicación WO2015188838A1 17/12/2015
UNIV COPENHAGEN¿[DK]
Solicitantes
The invention relates to a self-assembling multi-layered structure that is capable of self-assembling in an aqueous environment.
Resumen
The structure is capable of entrapping a compound, whereby the toxicity and/or aggregation capacity of the compound can be
decreased, and/or its solubility and thermal stability can be increased. The structure can further be used for delivering a compound
to an organism.
CELL DELIVERY SYSTEM AND METHOD
Nº publicación WO2015189205A1 17/12/2015
UNIV BELFAST¿[GB]
Solicitantes
The present invention is directed to a cell delivery system for the delivery of materials including nucleic acids across a biological
Resumen
barrier and methods of use thereof. The cell delivery system of the invention comprises a microprotrusion array composed of a
swellable and/or dissolvable polymer composition for use in the transport of a material across a biological barrier, wherein the
material comprises nanoparticles formed from a nucleic acid complexed with an amphipathic cell penetrating peptide and wherein
the microprotrusion array is loaded with the nanoparticles.
Alertas Tecnológicas
- 6 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
THERAPEUTIC GAS RELEASING SYSTEM
Nº publicación DE102014008685A1 17/12/2015
MEINEL LORENZ¿[DE]
Solicitantes
STEIGER CHRISTOPH¿[DE]
The present invention relates to therapeutic gas releasing systems. The
Resumen
system comprises compounds A and B, wherein A is a therapeutic gas
releasing molecule, A and B are not in contact with each other in the
therapeutic system during storage, and B enhances therapeutic gas
release from A when the therapeutic system is administered to a
patient.
Alertas Tecnológicas
- 7 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
THERAPEUTIC GAS RELEASING SYSTEM
Nº publicación WO2015188941A1 17/12/2015
MEINEL LORENZ¿[DE]
Solicitantes
STEIGER CHRISTOPH¿[DE]
The present invention relates to therapeutic gas releasing systems. The
Resumen
system comprises compounds A and B, wherein A is a therapeutic gas
releasing molecule, A and B are not in contact with each other in the
therapeutic system during storage, and B enhances therapeutic gas
release from A when the therapeutic system is administered to a
patient.
NANOCAPSULAR FORMULATION OF ACTIVE PHARMACEUTICAL INGREDIENTS
Nº publicación WO2015189387A1 17/12/2015
SANOFI SA¿[FR]
Solicitantes
UNIV SANTIAGO COMPOSTELA¿[ES]
Nanocapsule systems of at least one active pharmaceutical ingredient selected from the group consisting of at least one insulin,
Resumen
insulin analogue, insulin derivative, glucagon-like peptide-1 receptor agonist (GLP1 R agonist) and/or dual GLP-1
receptor/glucagon receptor agonist and/or or any combination thereof are disclosed.
FUNCTIONAL POLYMER GEL CONTAINING ORGANIC NANOTUBES AND METHOD FOR PRODUCING SAME
Nº publicación WO2015190604A1 17/12/2015
SEED CO LTD¿[JP]
Solicitantes
NAT INST OF ADVANCED IND SCIEN¿[JP]
The purpose of the present invention is to provide: a functional polymer gel which is able to be practically used as an ocular lens
Resumen
having excellent transparency and mechanical strength by uniformly dispersing organic nanotubes in a polymer gel without the
formation of agglomerates of the organic nanotubes in cases where the organic nanotubes are complexed into the polymer gel;
and a method for producing this functional polymer gel. The above-mentioned purpose is achieved by: a functional polymer gel
which is characterized by containing organic nanotubes and having a light transmittance of 80% or more; and a method for
producing this functional polymer gel.
A COPOLYMER AND A MICELLAR PARTICLE COMPRISING THE COPOLYMER
Nº publicación WO2015191009A1 17/12/2015
AGENCY SCIENCE TECH & RES¿[SG]
Solicitantes
There is provided a copolymer comprising a hydrophilic polymer, a hydrophobic polymer and a thermoresponsive polymer. There
Resumen
is also provided a micellar particle comprising the copolymer, and uses thereof. There is also provided a method of protecting a
cargo at a temperature that typically cases thermal degradation of said cargo.
Alertas Tecnológicas
- 8 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOSTRUCTURED CARRIERS FOR GUIDED AND TARGETED ON-DEMAND SUBSTANCE DELIVERY
Nº publicación WO2015192149A2 17/12/2015
UNIV CALIFORNIA¿[US]
Solicitantes
Methods, systems, and devices are disclosed for fabricating and implementing nanoscale and microscale structured carriers to
Resumen
provide guided, targeted, and on-demand delivery of molecules and biochemical substances for a variety of applications including
diagnosis and/or treatment (theranostics) of diseases in humans and animals. In some aspects, a nanostructure carrier can be
synthesized in the form of a nanobowl, which may include an actuatable capping particle that can be opened (and in some
implementations, closed) on demand. In some aspects, a nanostructure carrier can be synthesized in the form of a hollow porous
nanoparticle with a functionalized interior and/or exterior to attach payload substances and substances for magnetically guided
delivery and controlled release of substance payloads.
ORAL AND/OR BUCCAL COMPOSITION IN THE FORM OF A THIN FILM OF A WEAKLY SOLUBLE ACTIVE
INGREDIENT, METHOD OF PREPARING SAME AND USE OF SAME
Nº publicación US2015359735A1 17/12/2015
ETHYPHARM SA¿[FR]
Solicitantes
The present invention relates to an oral and/or buccal composition in
Resumen
the form of a thin film of a pharmaceutically active ingredient weakly
soluble in water and gastro-intestinal tract fluids, comprising particles
of said active ingredient dispersed in a film-forming polymer, at least
50% by weight of the total weight of the active ingredient having a
particle size distribution such that at least 90% of said particles have a
size below 1000 nm, preferably less than 800 nm, and even more
preferably less than 600 nm, and to the method of preparing that
composition and the use thereof.
GAS-GENERATING NANOPARTICLE
Nº publicación US2015359751A1 17/12/2015
IUCF HYU¿[KR]
Solicitantes
Disclosed are gas-generating nanoparticles comprising fine-grained calcium carbonate crystals and a biocompatible polymer, the
Resumen
fine-grained calcium carbonate crystals being encapsulated inside the biocompatible polymer, and the diagnosis and treatment of
diseases can be effectively performed at the same time by using a composition of the present disclosure.
Alertas Tecnológicas
- 9 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
ENZYME RESPONSIVE NANOCAPSULES FOR PROTEIN DELIVERY
Nº publicación US2015359752A1 17/12/2015
LU YUNFENG¿[US]
Solicitantes
SEGURA TATIANA¿[US]
ZHU SUWEI¿[US]
WEN JING¿[US]
The invention provides methods of making and using compositions
Resumen
comprising a polymer shell designed to deliver polypeptides to
selected environments. In embodiments of the invention, different
environmental conditions are harnessed to allow the selective
degradation of the polymer shell and the consequential release of one
or polypeptides encapsulated therein. In illustrative embodiments,
polymer components of the shell are interconnected by
peptide-containing crosslinker moieties, linkages which maintain the
integrity of the polymer shell under certain enviromental conditions,
but can also be cleaved when combined with a selected protease.
PREPARATION METHOD OF POLYMERIC MICELLAR NANOPARTICLES COMPOSITION CONTAINING A POORLY
WATER-SOLUBLE DRUG
Nº publicación US2015359777A1 17/12/2015
SAMYANG BIOPHARMACEUTICALS¿[KR]
Solicitantes
Provided is a method for preparing a poorly water-soluble drug-containing polymeric micellar nanoparticle composition, which
Resumen
includes: dissolving a poorly water-soluble drug, a salt of polylactic acid or polylactic acid derivative, whose carboxylic acid end
is bound to an alkali metal ion, and an amphiphilic block copolymer into an organic solvent; and adding an aqueous solution to
the resultant mixture in the organic solvent to form micelles, wherein the method requires no separate operation to remove the
organic solvent prior to the formation of micelles. The method for preparing a poorly water-soluble drug-containing polymeric
micellar nanoparticle composition is simple, reduces the processing time, and is amenable to mass production.
METHODS AND COMPOSITIONS COMPRISING A C-TERMINAL BAX PEPTIDE
Nº publicación US2015359841A1 17/12/2015
UNIV CENTRAL FLORIDA RES FOUND¿[US]
Solicitantes
In an aspect, the invention relates to compositions and methods for
Resumen
permeabilizing membranes of cells. In an aspect, the invention relates
to compositions and methods for killing cells. In an aspect, the
invention relates to compositions and methods of permeabilizing the
membranes of cancer cells or microbial cells.
Alertas Tecnológicas
- 10 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
THERMAL THERAPEUTIC REAGENT
Nº publicación US2015359885A1 17/12/2015
CHIEH JEN-JIE¿[TW]
Solicitantes
A thermal therapeutic reagent is provided. The thermal therapeutic reagent comprises a plurality of magnetic nanoparticles, a
Resumen
plurality of surfactants coating on the magnetic nanoparticles respectively, and a polar magnetic fluid for delivering the magnetic
nanoparticles to a target site. Wherein, the magnetic nanoparticles are capable of being activated under a magnetic field applied at
the target site. Another thermal therapeutic reagent comprising a non-polar magnetic fluid is also provided.
SYSTEM AND METHODS FOR NANOSTRUCTURE PROTECTED DELIVERY OF TREATMENT AGENT AND SELECTIVE
RELEASE THEREOF
Nº publicación US2015359886A1 17/12/2015
UNIV BROWN¿[US]
Solicitantes
A method and nanoparticle construct provides shielded delivery of a
Resumen
drug or agent to a tissue or treatment site, and release of the agent may
be triggered externally. Carbon nanotubes (CNTs) are filled with the
therapeutic agent in a temperature sensitive gel, and release of the
agent is effected by inductive heating, e.g. applying an alternating or
pulsed magnetic field, or electrical field. The CNTs may be
functionalized for solubility, drug absorption, responsivity to pH,
enzyme catalysis, and/or ambient biological environment.
Encapsulation within the nanostructure protects the intracorporal or
surrounding cellular environment from the potentially toxic cargo and prevents the degradation of the cargo during delivery. By
releasing at or in the target tissue extremely small amounts of the agent may achieve an effective level of treatment, as measured
by cell apoptosis, tumor shrinkage or other treatment effect while safely avoiding systemic damage.
HEAT-SENSITIVE NANOPARTICLE SYSTEM
Nº publicación US2015359887A1 17/12/2015
FOND ISTITUTO ITALIANO DI TECNOLOGIA¿[IT]
Solicitantes
The present invention concerns a heat-sensitive system comprising at
Resumen
least one nanoparticle bound covalently to at least one thermolabile
molecule comprising an azo -N=N- functional group -N=N- in turn
bound covalently to at least one active molecule selected from a
fluorophore molecule and a drug. The system of the invention is able
to convert an electromagnetic radiation into thermal energy exposed to
an alternating magnetic field. Uses of the system according to the
invention are also provided.
Alertas Tecnológicas
- 11 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NOVEL LOW MOLECULAR WEIGHT CYCLIC AMINE CONTAINING CATIONIC LIPIDS FOR OLIGONUCLEOTIDE
DELIVERY
Nº publicación US2015361434A1 17/12/2015
SIRNA THERAPEUTICS INC¿[US]
Solicitantes
The instant invention provides for novel cationic lipids that can be
Resumen
used in combination with other lipid components such as cholesterol
and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is
an object of the instant invention to provide a cationic lipid scaffold
that demonstrates enhanced efficacy along with lower liver toxicity as
a result of lower lipid levels in the liver. The present invention
employs low molecular weight cationic lipids comprising at least one
short lipid chain to enhance the efficiency and tolerability of in vivo
delivery of siRNA.
NANOPARTICULATE COMPOSITIONS AND FORMULATIONS OF PIPERAZINE COMPOUNDS
Nº publicación AU2014302085A1 17/12/2015
REXAHN PHARMACEUTICALS INC
Solicitantes
The present invention relates to storage stable nanoparticulate
Resumen
compositions of piperazine compounds. The pharmaceutical
compositions comprising the nanoparticulate compositions that are
useful for the treatment and prevention of proliferative diseases
including cancer are also described.
Alertas Tecnológicas
- 12 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
METHODS OF TREATING SPINAL CORD INJURY
Nº publicación EP2953640A2 16/12/2015
CLEVELAND CLINIC FOUNDATION¿[US]
Solicitantes
The invention is directed to a method of treating a spinal cord injury, a
Resumen
neurodegenerative disease or a neuronal injury in an individual in
need thereof comprising administering an effective amount of
superoxide dismutase (SOD) and catalase to the individual, wherein
the superoxide dismutase and the catalase are encapsulated in one or
more nanoparticles that release the SOD and catalase upon
administration. Another aspect of the invention is directed to
compositions comprising superoxide dismutase (SOD) and catalase
encapsulated in one or more nanoparticles.
BIODEGRADABLE AND CLINICALLY-COMPATIBLE NANOP ARTICLES AS DRUG DELIVERY CARRIERS
Nº publicación EP2953646A1 16/12/2015
1GLOBE HEALTH INST LLC¿[US]
Solicitantes
The present invention relates to the composition of a nanoparticle
Resumen
based on a magnesium salt, and methods of drug delivery using the
nanoparticle. A preferred embodiment uses magnesium phosphate,
with or without a shell to deliver aiRNA and/or siRNA. The
nanoparticles of the present invention are also effective when
administered orally.
Alertas Tecnológicas
- 13 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
Peptide functionalised bone biospecific agent with contrast agent core surrounded by outer shell
Nº publicación EP2953682A1 16/12/2015
ORTHOPAEDIC RES UK¿[GB]
Solicitantes
A bone biospecific agent 2 is disclosed comprising a contrast material
Resumen
core 4, which is visible using Magnetic Resonance Imaging (MRI) or
Computed Tomography (CT). The contrast material core is
surrounded by a polymeric shell 6, which is functionalised with a bone
targeting peptide 8. In use, the peptide 8 targets the biospecific agent 2
to bone. The bone biospecific agent can be used in diagnostic imaging
techniques, such as MRI and CT, and in imaging bone remodelling
activities, detecting and treating pathological bone conditions and/or
bone repair processes. The invention extends to the diagnosis and/or
treatment of bone disease and bone pathologies using the biospecific
agents. The bone targeting peptide may comprise an amino acid
sequence which mimics osteoprogeterin (OPG).
NANOPARTICLES CONTAINING A TAXANE AND THEIR USE
Nº publicación EP2953648A1 16/12/2015
ANP TECHNOLOGIES INC¿[US]
Solicitantes
FULGENT THERAPEUTICS INC¿[US]
Symmetrically and asymmetrically branched homopolymers are
Resumen
modified a t the surface level with functional groups that enable
forming aggregates with a taxane, such as, paclilaxei and its
derivatives, which are water insoluble or poorly water soluble. The
aggregates are formed by interaction of a taxane and a homopolymer.
Such aggregates improve drug solubility, stability, delivery and
efficacy.
Alertas Tecnológicas
- 14 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
BIODEGRADABLE BIONANOPARTICLES FOR RELEASING THE GSE24-2 PEPTIDE, METHOD FOR THE PRODUCTION
THEREOF, AND USE OF SAME
Nº publicación EP2955224A1 16/12/2015
CONSEJO SUPERIOR INVESTIGACION¿[ES]
Solicitantes
UNIV AUTÓNOMA DE MADRID UAM¿[ES]
UNIV DEL PAÍS VASCO EUSKAL HERRIKO UNIBERTSITATEA UPV EHU¿[ES]
CT DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS¿[ES]
The invention relates to biodegradable PLGA bionanoparticles
Resumen
encapsulating the GSE24-2 peptide with telomerase activity, and to
pharmaceutical, cosmetic and biotechnological compositions
comprising same. The pharmaceutical compositions are useful for
treating diseases presenting a telomerase deficiency, such as
dyskeratosis congenita, and diseases presenting ageing characteristics,
such as Werner syndrome, Rothmund Thompson syndrome, and other
diseases where there is DNA damage such as ataxia telangiectasia.
The relation also relates to the method for producing said
bionanoparticles by means of a w/o/w double emulsion technique.
Alertas Tecnológicas
- 15 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
METHODS OF TREATING MELANOMA
Nº publicación EP2953622A1 16/12/2015
ABRAXIS BIOSCIENCE LLC¿[US]
Solicitantes
Provided herein are methods for the treatment of melanoma
Resumen
comprising administration of a composition comprising nanoparticles
comprising taxane and a carrier protein.
SURGICAL INSTRUMENT STRINGER TRAY SYSTEM
Nº publicación EP2953556A1 16/12/2015
RESTORE MEDICAL SOLUTIONS INC¿[US]
Solicitantes
POSITIVELY CHARGED POLYSACCHARIDES FOR RNA TRANSFECTION
Nº publicación EP2953647A1 16/12/2015
BG NEGEV TECHNOLOGIES & APPLIC LTD¿[IL]
Solicitantes
UNIV RAMOT¿[IL]
A complex comprising RNA and a positively charged modified
Resumen
polysaccharide selected from starch, amylose, amylopectin, galactan,
chitosan, or dextrin, pharmaceutical composition comprising it, and its
use in RNA transfection are provided. Methods for RNA transfection,
gene therapy and treatment of a disease, disorder or condition
comprising using the complex are also provided. The use of positively
charged modified polysaccharide selected from starch, amylose,
amylopectin, galactan, chitosan, or dextrin, in RNA transfection into
cells is further provided.
Alertas Tecnológicas
- 16 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
Nº publicación HK1204970A1 11/12/2015
CERULEAN PHARMA INC¿[US]
Solicitantes
Described herein are polymer-agent conjugates and particles, which
Resumen
can be used, for example, in the treatment of cancer. Also described
herein are mixtures, compositions and dosage forms containing the
particles, methods of using the particles (e.g., to treat a disorder), kits
including the polymer-agent conjugates and particles, methods of
making the polymer-agent conjugates and particles, methods of
storing the particles and methods of analyzing the particles.
AMPHIPHILIC DERIVATIVES OF TRIAZAMACROCYCLIC COMPOUNDS, PRODUCTS AND COMPOSITION INCLUDING
SAME, AND SYNTHESIS METHODS AND USES THEREOF
Nº publicación US2015353514A1 10/12/2015
BIOCELLCHALLENGE¿[FR]
Solicitantes
The invention relates to amphiphilic derivatives of a triazamacrocyclic
Resumen
compound, as well as to said derivatives as active molecule
transporters. The invention also relates to a nanodrug including at
least one amphiphilic derivative of a triazamacrocyclic compound and
at least one active molecule of a protein such as an antibody, in
particular for the treatment of autoimmune diseases or for the
treatment of cancer.
Alertas Tecnológicas
- 17 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOFIBER HAVING SELF-HEATING PROPERTIES AND BIOLOGICALLY ACTIVE SUBSTANCE RELEASE PROPERTIES,
PRODUCTION METHOD FOR SAME, AND NONWOVEN FABRIC HAVING SELF-HEATING PROPERTIES AND
BIOLOGICALLY ACTIVE SUBSTANCE RELEASE CAPABILITIES
Nº publicación US2015352209A1 10/12/2015
NAT INST FOR MATERIALS SCIENCE¿[JP]
Solicitantes
The purpose of the present invention is to provide: a nanofiber having
Resumen
self-heating properties and biologically active substance release
properties, which is capable of simultaneously releasing a
pharmacological agent when induced to self-heat, and which can be
utilized safely in the body, without diffusing self-heating
nanoparticles; a production method for the same; and a nonwoven
fabric having self-heating properties and biologically active substance
release capabilities. Provided are: fibers 50 nm-50 [mu]m in diameter,
having length equal to 100 times or more the diameter, and containing
self-heating particles that emit heat in response to an external stimuli,
a stimuli-responsive polymer that directly or indirectly reacts with the
stimuli to undergo a change in a physical property, and a biologically
active substance retained in the stimuli-responsive polymer, the fibers
releasing the biologically active substance to the outside in response to
a change in a physical property of the stimuli-responsive polymer; a
production method for the same, and a nonwoven fabric having
self-heating properties and biologically active substance release
capabilities.
POLYMERIC NANOPARTICLES AND A PROCESS OF PREPARATION THEREOF
Nº publicación US2015353676A1 10/12/2015
NANOPROTEAGEN LTD¿[KY]
Solicitantes
NANOPROTEAGEN LTD¿[KY]
The present invention relates to the field of nanotechnology, in particular, to the production of biodegradable polymeric
Resumen
nanoparticles. The present invention provides a biodegradable polymeric nanoparticle made up of a block copolymer and a
process for producing the same. The nanoparticles are produced without the use of any emulsifiers and have a size ranging from
30-120 nm. The methods of controlling the drug loading capacity are disclosed along with the process of producing entity-loaded
nanoparticles. Compositions comprising the nanoparticles and their use in therapeutics, diagnostics and theranostics are also
disclosed.
Alertas Tecnológicas
- 18 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
AN UPCONVERSION FLUORESCENT NANOPARTICLE
Nº publicación US2015353821A1 10/12/2015
UNIV SINGAPORE¿[SG]
Solicitantes
UNIV SINGAPORE¿[SG]
The present invention provides upconversion fluorescent nanoparticles
Resumen
comprising: a first nanocrystal layer, a second nanocrystal layer, and
an energy absorbing layer disposed between the first nanocrystal layer
and the second nanocrystal layer. There is also provided an article of
manufacture comprising the upconversion fluorescent nanoparticles,
as well as a bio-imaging and/or bio-detection apparatus comprising
the upconversion fluorescent nanoparticles. The bio-imaging and/or
bio-detection apparatus may further comprise a biomolecule and a
source of excitation.
MATERIAL AND STRUCTURES FOR CELL DELIVERY
Nº publicación WO2015187098A1 10/12/2015
AGENCY SCIENCE TECH & RES¿[SG]
Solicitantes
Disclosed are macro- or micro-structures. These structures may be suitable for encapsulating biologically active material, wherein
Resumen
the structure comprises a negatively charged polymer. Also disclosed are methods of using the structures, uses of the structures
and methods of manufacturing thereof.
GALENIC FORM FOR THE ADMINISTRATION OF AN ACTIVE INGREDIENT
Nº publicación US2015352038A1 10/12/2015
PEROVITCH PHILIPPE¿[US]
Solicitantes
AUZERIE JACK¿[US]
ROSSELLO RAPHAEL¿[FR]
Galenic form for the oral transmucosal administration of an active ingredient for accelerated induction of sleep and/or the
Resumen
treatment of sleep disorders and/or the treatment of a central nervous system attack, wherein said active ingredient is lipophilic or
amphiphilic and is in a state of stable and complete dissolution in an aqueous-alcoholic solution comprising between 35% and
70% by weight of ethanol and between 30% and 65% by weight of water, generating, in this aqueous-alcoholic solution, the
formation of nanostructures of said active ingredient under consideration, facilitating the crossing of the blood-brain barrier by
said active ingredient, wherein said active ingredient is in base and/or salt form and belongs to the chemical families of sleep
inducers or modulators of lipophilic or amphiphilic nature and having a molecular weight of less than 1000 daltons, wherein said
active ingredient is chosen from the imidazopyridine family, comprising zolpidem, the cyclopyrrolone family, comprising
eszopiclone, the pyrazolopyrimidine family, comprising zaleplon, the benzodiazepine family, comprising midazolam and
brotizolam, the H1 antihistamine sedative family, comprising doxylamine and cyproheptadine, and/or the melatonin and
melatonin agonist family, comprising melatonin, ramelteon and agomelatine, wherein the volume of said aqueous-alcoholic
solution is less than or equal to 2 ml and said active ingredient is present at a dose of less than or equal to 8 mg, all of said active
ingredient being absorbed transmucosally through the mucosae of the floor of the oral cavity, in particular the gingivo-jugal,
para-gingival, jugal or sublingual mucosae.
Alertas Tecnológicas
- 19 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
POLYVALENT RNA-NANOPARTICLE COMPOSITIONS
Nº publicación US2015352138A1 10/12/2015
UNIV NORTHWESTERN¿[US]
Solicitantes
The present invention concerns nanoparticles functionalized with
Resumen
duplex RNA for a variety of uses, including but not limited to gene
regulation. More specifically, the disclosure provides a new strategy
for conjugating RNA to a nanoparticle to achieve increased stability
and activity.
NANOPARTICLE DRUG DELIVERY SYSTEMS
Nº publicación EP2950785A2 09/12/2015
UNIV NOTRE DAME DU LAC¿[US]
Solicitantes
The invention provides pharmaceutical compositions and method of
Resumen
using the compositions, wherein the compositions comprise liposomes
or micelles that contain one or more targeting peptides and/or
anticancer drugs. In various embodiments, the components of the
liposomes can include a) a phospholipid and optionally a lipid that is
not a phospholipid; b) a pegylated lipid; c) a peptide-ethylene glycol
(EG)-lipid conjugate wherein the peptide is a targeting ligand, and d)
one or more drug-conjugated lipid, encapsulated drugs, or a
combination thereof. The peptide- EG-lipid conjugate can be, for example, a compound of Formula (I) or Formula (II). The
ethylene glycol (EG) segments of the peptide-EG-lipid conjugate can be, for example, EG6 to about EG36; and the EG segment
can be conjugated to one or more lysine moieties.
Alertas Tecnológicas
- 20 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
J-AGGREGATE FORMING NANOPARTICLE
Nº publicación EP2950827A1 09/12/2015
UNIV HEALTH NETWORK¿[CA]
Solicitantes
There is provided herein a nanovesicle having a bilayer comprising a
Resumen
saturated first phospholipid and no more than about 15 molar % of a
second phospholipid covalently conjugated to a J-aggregate forming
dye.
COMPOSITIONS COMPRISING SACCHARIDE BINDING MOIETIES AND METHODS FOR TARGETED THERAPY
Nº publicación EP2952210A2 09/12/2015
UNIV EMORY¿[US]
Solicitantes
GEORGIA TECH RES INST¿[US]
The disclosure relates to uses of saccharide binding moieties, e.g.,
Resumen
lectins for targeting cells, typically cancer stem cells. In certain
embodiments, the disclosure relates to conjugates comprising: a) a
saccharide binding moiety; b) a polymer; and c) a therapeutic agent;
wherein the saccharide binding protein is covalently attached to the
polymer.
Alertas Tecnológicas
- 21 de 22 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
Pharmaceutical formulations for the treatment of pulmonary arterial hypertension
Nº publicación GB2526897A 09/12/2015
HEART BIOTECH PHARMA LTD¿[GB]
Solicitantes
Pharmaceutical formulations are described for use in the treatment of
Resumen
pulmonary arterial hypertension (PAH). The formulations comprise
polymeric nanoparticles encapsulated within crosslinked polymeric
hydrogel microparticles, wherein the polymeric nanoparticles carry a
therapeutic agent suitable for treatment of PAH loaded within them
(for example, prostacyclin synthetic analogs, PPAR agonists and NO
donors). Preferred formulations are inhalable, dry powder
pharmaceutical formulations, which are able to swell on
administration to the lungs of a patient.
Alertas Tecnológicas
- 22 de 22 -
NANOFÁRMACOS