1. Art and Diseño

Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOFÁRMACOS
67 Resultados
Solicitudes de Patente publicadas a nivel mundial en los últimos 30 dias.
Datos actualizados a 08/02/2015 [19:13:00]
USES OF POROUS NANOSTRUCTURE IN DELIVERY
Nº publicación US2015037249A1 05/02/2015
NVIGEN INC¿[US]
Solicitantes
The present invention relates to methods for delivering at least one
Resumen
agent unto or into a biological sample or a biological subject. The
methods comprise a step of contacting the biological sample or subject
with a payload-carrying nanostructure. The nanostructure can be a
porous low density nanostructure.
Alertas Tecnológicas
- 1 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging
Nº publicación US2015037419A1 05/02/2015
SANOFI SA¿[FR]
Solicitantes
The present invention concerns novel functional PEG-PLA containing
Resumen
copolymers, the nanoparticles containing the same, their process of
preparation and their use for site specific targeted drug delivery and
imaging.
TUMOUR-TARGETED THERANOSTIC
Nº publicación WO2015014756A1 05/02/2015
UNIV BRADFORD¿[GB]
Solicitantes
UNIV LELAND STANFORD JUNIOR¿[US]
The present inventors have harnessed the targeting of nanoparticles to tumour sites, combined with the tumour site specific
Resumen
elevated MMP-14 activity within one conjugate to simultaneously deliver a vascular disrupting agent (VDA) and a MRI contrast
agent to a tumour site. The MMP activatable conjugate of the present invention provides both therapeutic and diagnostic
functions - and is referred to as a "theranostic". The theranostic conjugate of the present invention achieves the benefits of tumour
site specificity, VDA delivery and MRI contrast agent delivery in a single theranostic conjugate. Consequently, the present
invention provides a cancer "theranostic" which improves therapeutic efficacy whilst simultaneously reducing dose-limiting
systemic toxicities and provides a tool for rapidly and non-invasively identifying tumour location, monitoring drug delivery and
pharmacodynamics.
GELATIN-BASED NANOPARTICLE COMPLEX FOR TUMOR-TARGETED DELIVERY OF siRNA AND METHOD FOR
PREPARING THE SAME
Nº publicación US2015038690A1 05/02/2015
KOREA INST SCI & TECH¿[KR]
Solicitantes
Disclosed is a gelatin-based nanoparticle complex for tumor-targeted delivery of siRNA for specific gene silencing in tumor cells.
Resumen
The gelatin-based nanoparticle complex includes: poly-siRNA chains whose ends are modified with thiol groups
and thiolated gelatin bound to the poly-siRNA chains through disulfide crosslinking and charge interactions. The gelatin-based
nanoparticle complex is not degraded in the bloodstream and can be efficiently absorbed into tumor cells without cytotoxicity.
The delivered siRNA can effectively silence target gene expression. Also disclosed is a method for preparing the gelatin-based
nanoparticle complex.
Alertas Tecnológicas
- 2 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
DISAGGREGATION OF AGGREGATED NANODIAMOND CLUSTERS
Nº publicación US2015038593A1 05/02/2015
GOGOTSI YURY¿[US]
Solicitantes
MOCHALIN VADYM¿[US]
UNIV DREXEL¿[US]
The present invention is directed to methods of disaggregating
Resumen
nanodiamond clusters, especially those clusters typically produced
from detonation syntheses, the nanodiamond particles and dispersions
produced from these disaggregation processes, and compositions
derived from these nanodiamond particles and dispersions.
METHODS AND APPARATUSES FOR SURFACE FUNCTIONALIZATION AND COATING OF NANOCRYSTALS
Nº publicación US2015038578A1 05/02/2015
NIKOOBAKHT BABAK¿[US]
Solicitantes
The present disclosure describes a method and series of compositions for surface functionalization of nanoparticles that eliminates
Resumen
the possibility of ligand loss in alien environments. In particular, the present disclosure provides method and compositions for
production of highly-stable surface-functionalized nanorods of noble metals for in-vivo applications as well as use in composite
materials.
NANO DELIVERY SYSTEMS
Nº publicación US2015037427A1 05/02/2015
YISSUM RES DEV CO¿[IL]
Solicitantes
The present invention makes use of a unique methodology of double
Resumen
nano- encapsulation for protecting and controlling the release of active
agents, either hydrophobic or hydrophilic, from stable nanoparticles of
opposite characteristics. The protection of the active agent was
achieved by loading the agent to be protected, into nanocarriers, which
were subsequently encapsulated into sub-micron nanoparticles. The
sub-micron nanoparticles formation has been successfully achieved by
the use of novel nano spray techniques.
Alertas Tecnológicas
- 3 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging
Nº publicación US2015037419A1 05/02/2015
SANOFI SA¿[FR]
Solicitantes
The present invention concerns novel functional PEG-PLA containing
Resumen
copolymers, the nanoparticles containing the same, their process of
preparation and their use for site specific targeted drug delivery and
imaging.
USES OF POROUS NANOSTRUCTURE IN DELIVERY
Nº publicación US2015037249A1 05/02/2015
NVIGEN INC¿[US]
Solicitantes
The present invention relates to methods for delivering at least one
Resumen
agent unto or into a biological sample or a biological subject. The
methods comprise a step of contacting the biological sample or subject
with a payload-carrying nanostructure. The nanostructure can be a
porous low density nanostructure.
Alertas Tecnológicas
- 4 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
COSMETIC TEXTILE FIBER, METHOD FOR OBTAINING IT AND USE THEREOF
Nº publicación US2015035195A1 05/02/2015
NYLSTAR S A¿[ES]
Solicitantes
The present invention describes a polyamide textile fiber comprising
Resumen
conjugated nanoparticles homogeneously dispersed in the fiber,
selected from polyethylene glycol-conjugated platinum nanoparticles,
hyaluronic acid- conjugated gold nanoparticles and mixtures thereof.
The invention also describes how to obtain it as well as its use in a
cosmetic skin treatment as a system for the release of said conjugated
nanoparticles.
GELATIN-BASED NANOPARTICLE COMPLEX FOR TUMOR-TARGETED DELIVERY OF siRNA AND METHOD FOR
PREPARING THE SAME
Nº publicación US2015038690A1 05/02/2015
KOREA INST SCI & TECH¿[KR]
Solicitantes
Disclosed is a gelatin-based nanoparticle complex for tumor-targeted delivery of siRNA for specific gene silencing in tumor cells.
Resumen
The gelatin-based nanoparticle complex includes: poly-siRNA chains whose ends are modified with thiol groups
and thiolated gelatin bound to the poly-siRNA chains through disulfide crosslinking and charge interactions. The gelatin-based
nanoparticle complex is not degraded in the bloodstream and can be efficiently absorbed into tumor cells without cytotoxicity.
The delivered siRNA can effectively silence target gene expression. Also disclosed is a method for preparing the gelatin-based
nanoparticle complex.
DISAGGREGATION OF AGGREGATED NANODIAMOND CLUSTERS
Nº publicación US2015038593A1 05/02/2015
GOGOTSI YURY¿[US]
Solicitantes
MOCHALIN VADYM¿[US]
UNIV DREXEL¿[US]
The present invention is directed to methods of disaggregating
Resumen
nanodiamond clusters, especially those clusters typically produced
from detonation syntheses, the nanodiamond particles and dispersions
produced from these disaggregation processes, and compositions
derived from these nanodiamond particles and dispersions.
Alertas Tecnológicas
- 5 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
METHODS AND APPARATUSES FOR SURFACE FUNCTIONALIZATION AND COATING OF NANOCRYSTALS
Nº publicación US2015038578A1 05/02/2015
NIKOOBAKHT BABAK¿[US]
Solicitantes
The present disclosure describes a method and series of compositions for surface functionalization of nanoparticles that eliminates
Resumen
the possibility of ligand loss in alien environments. In particular, the present disclosure provides method and compositions for
production of highly-stable surface-functionalized nanorods of noble metals for in-vivo applications as well as use in composite
materials.
NANO DELIVERY SYSTEMS
Nº publicación US2015037427A1 05/02/2015
YISSUM RES DEV CO¿[IL]
Solicitantes
The present invention makes use of a unique methodology of double
Resumen
nano- encapsulation for protecting and controlling the release of active
agents, either hydrophobic or hydrophilic, from stable nanoparticles of
opposite characteristics. The protection of the active agent was
achieved by loading the agent to be protected, into nanocarriers, which
were subsequently encapsulated into sub-micron nanoparticles. The
sub-micron nanoparticles formation has been successfully achieved by
the use of novel nano spray techniques.
Alertas Tecnológicas
- 6 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
COSMETIC TEXTILE FIBER, METHOD FOR OBTAINING IT AND USE THEREOF
Nº publicación US2015035195A1 05/02/2015
NYLSTAR S A¿[ES]
Solicitantes
The present invention describes a polyamide textile fiber comprising
Resumen
conjugated nanoparticles homogeneously dispersed in the fiber,
selected from polyethylene glycol-conjugated platinum nanoparticles,
hyaluronic acid- conjugated gold nanoparticles and mixtures thereof.
The invention also describes how to obtain it as well as its use in a
cosmetic skin treatment as a system for the release of said conjugated
nanoparticles.
DIETHER BASED BIODEGRADABLE CATIONIC LIPIDS FOR siRNA DELIVERY
Nº publicación EP2830594A1 04/02/2015
SIRNA THERAPEUTICS INC¿[US]
Solicitantes
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and
Resumen
PEG-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with
lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic
lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency
and tolerability of in vivo delivery of siRNA.
Alertas Tecnológicas
- 7 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
LIPID-COATED NUCLEIC ACID NANOSTRUCTURES OF DEFINED SHAPE
Nº publicación EP2830991A1 04/02/2015
HARVARD COLLEGE¿[US]
Solicitantes
The invention provides nanoparticles containing a nucleic acid
Resumen
nanostructure, of defined shape and size, linked to a hydrophobic
moiety and coated by lipids, compositions comprising the
nanoparticles, and methods of producing and methods of using the
nanoparticles.
Method to block site-specifically chemokine-related inflammatory processes in vascular diseases and metastasis
Nº publicación EP2832373A1 04/02/2015
EXPERIMENTELLE PHARMAKOLOGIE & ONKOLOGIE BERLIN BUCH¿[DE]
Solicitantes
INST OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMINESCU¿[RO]
UNIV POLITEHNICA OF BUCHAREST¿[RO]
UNIV BONN¿[DE]
ISTANBUL UNIVERSITY¿[TR]
UNIV ZUERICH¿[CH]
The invention provides a method for blocking site-specifically chemokine-related inflammatory processes in vascular diseases
Resumen
and metastasis employing vascular targeted nanocarrier. In particular, the present invention provides two types of targeted n ano c
arrier (NC) with encapsulated c hemokine a ntagonists (CA) or c hemokine r eceptor a ntagonists (CRA): stabilised t
arget-sensitive l iposomes (TSL) and p olymeric n anoparticles (PNP). Both types of nanocarrier have attached on their surface
monoclonal antibodies or peptides that recognize VCAM-1 expressed on activated endothelial cells (EC). After binding of the
nanocarrier to the VCAM-1 expressed on EC, the encapsulated CA or CRA are released and will block the interaction between
chemokine and chemokine receptors. This will lead to an inhibition of transmigration of leukocytes (in atherosclerosis) or of
tumor metastatic cells (in cancer). The invention provides a carrier system which delivers effective concentrations of drugs
specifically to the diseased (target) sites and reduces the drug concentrations at non-target sites. This results in a reduced, even
absent, occurrence of side effects. The nanocarriers described in this invention have the potential to function as long-lasting
vehicles for delivering selectively CA or CRA to activated endothelium.
Alertas Tecnológicas
- 8 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
TRIGGER-RESPONSIVE CHAIN-SHATTERING POLYMERS
Nº publicación EP2831142A2 04/02/2015
UNIV ILLINOIS¿[US]
Solicitantes
Disclosed are polymers containing a backbone comprising alternating
Resumen
N-protected hydroxymethylaniline units ("spacer") and linker units.
NANOPARTICLE AGGREGATES CONTAINING OSTEOPONTIN AND CALCIUM- AND/OR STRONTIUM-CONTAINING
PARTICLES
Nº publicación EP2830647A1 04/02/2015
ARLA FOODS AMBA¿[DK]
Solicitantes
The present invention relates to nanoparticle aggregates comprising
Resumen
osteopontin (OPN) and one or more particles containing calcium
and/or strontium and to their use for reducing or preventing biofilm
growth or for removing biofilm. The invention furthermore relates to
the use of the nanoparticle aggregates for treating, alleviating or
preventing biofilm-related diseases.
Alertas Tecnológicas
- 9 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
MULTICOMPARTMENTAL LIPID NANOPARTICLES
Nº publicación FR3008900A1 30/01/2015
CENTRE NAT RECH SCIENT¿[FR]
Solicitantes
UNIV PARIS XI PARIS SUD¿[FR]
The present invention relates to novel multicompartmental lipid
Resumen
nanoparticles (or cellisomes) with excellent stability comprising a first
lipophilic compartment (lipid matrix) partly anchored to a second
hydrophilic compartment delimited by a phospholipid bilayer
(bilayer), as well as the method for preparing same and the use thereof
as a vector for administering a wide variety of molecules of interest.
NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES
Nº publicación US2015030541A1 29/01/2015
MALLINCKRODT LLC¿[US]
Solicitantes
The present invention provides phosphonate conjugates and methods
Resumen
of preparing the phosphonate conjugates so as to allow, for example,
improved methods and compounds for modifying the surface of a
nanoparticle to increase in vivo circulation times and targeted delivery
performance.
Alertas Tecnológicas
- 10 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
COMPOSITIONS AND METHODS FOR UPREGULATING HIPPOCAMPAL PLASTICITY AND HIPPOCAMPUS-DEPENDENT
LEARNING AND MEMORY
Nº publicación WO2015013451A2 29/01/2015
REVALESIO CORP¿[US]
Solicitantes
Provided are methods for enhancing hippocampal plasticity and hippocampal-mediated learning and memory, and/or enhancing
Resumen
the synaptic maturation of neurons, and/or optimizing or enhancing neuronal synaptic transmission, and/or enhancing intracellular
oxygen delivery or utilization, and/or enhancing ATP synthesis, comprising administration, to a subject in need thereof of a
sufficient amount over a sufficient time, of an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures (e.g.,
nanobubbles) having an average diameter of less than 100 nm (e.g., in at least one subject group selected from but not limited to
normal subjects, subjects recovering from neurological trauma (e.g., accidents or injury to the brain, stroke, oxygen deprivation,
drowning, and asphyxia), and subjects with learning disorders (e.g., dyslexia, dyscalculia, dysgraphia, dyspraxia (sensory
integration disorder), dysphasia/aphasia, auditory processing disorder, non-verbal learning disorder, visual processing disorder,
and attention deficit disorder (ADD)).
NANOEMULSIONS OF HYDROPHOBIC PLATINUM DERIVATIVE
Nº publicación WO2015013566A1 29/01/2015
NEMUCORE MEDICAL INNOVATIONS INC¿[US]
Solicitantes
GANTA SRINIVAS¿[US]
COLEMAN TIMOTHY P¿[US]
Provided are nanoemulsion formulations useful for the delivery of hydrophobic platinum chemotherapeutic drugs to cancer
Resumen
patients, as well as methods of their preparation and use.
FIBRIN HYDROGELS COMPRISING PLASMONIC NANOPARTICLES
Nº publicación ES2527800A1 29/01/2015
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PAZ FIBHULP¿[ES]
Solicitantes
CT DE INVESTIGACION BIOMEDICA EN RED EN BIOINGENIERIA BIOMATERIALES Y NANOMEDICINA CIBER
BBN¿[ES]
UNIV ZARAGOZA¿[ES]
The invention relates to a photothermal composition comprising a
Resumen
fibrin hydrogel matrix or a mixture of the precursors thereof, thrombin
and fibrinogen, in which hydrogel plasmonic nanoparticles and
heat-sensitive effectors are embedded, said effectors containing
therapeutic agents that are released by applying electromagnetic
radiation of a determined intensity and wavelength to the composition.
The photothermal composition is suitable for generating hyperthermia
in biological tissues in which said composition is implanted. The
invention therefore also relates to the use of the composition for the
destruction of tumours, the treatment of infections or the regeneration
of tissues, as well as for the controlled administration of therapeutic
agents.
Alertas Tecnológicas
- 11 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
CARRIER NANOPARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
Nº publicación US2015031832A1 29/01/2015
CALIFORNIA INST OF TECHN¿[US]
Solicitantes
Carrier nanoparticles comprising a polymer containing a polyol
Resumen
coupled to a polymer containing a boronic acid, configured to present
the polymer containing a boronic acid to an environment external to
the nanoparticle and related compositions, methods and systems.
Alertas Tecnológicas
- 12 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOCONJUGATES ABLE TO CROSS THE BLOOD-BRAIN BARRIER
Nº publicación US2015031745A1 29/01/2015
MIRKIN CHAD A¿[US]
Solicitantes
KO CAROLINE H¿[US]
STEGH ALEXANDER¿[US]
GILJOHANN DAVID A¿[US]
LUCIANO JANINA¿[US]
JENSEN SAMUEL A¿[US]
UNIV NORTHWESTERN¿[IL]
Polyvalent nanoconjugates address the critical challenges in
Resumen
therapeutic use. The single-entity, targeted therapeutic is able to cross
the blood-brain barrier (BBB) and is thus effective in the treatment of
central nervous system (CNS) disorders. Further, despite the
tremendously high cellular uptake of nanoconjugates, they exhibit no
toxicity in the cell types tested thus far. This property is critical for
therapeutic agent delivery applications for reducing off-target effects.
METHOD FOR PREPARING NANO PARTICLES
Nº publicación US2015031707A1 29/01/2015
BIO SYNECTICS INC¿[KR]
Solicitantes
The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the
Resumen
present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point
or glass transition temperature of 80 DEG C or lower and an active material, and mills the mixture using a roller mill, to thereby
prepare nano particle powder from the active material.
AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF
PREPARATION AND USES THEREOF
Nº publicación US2015031644A1 29/01/2015
UNIV SHANGHAI JIAOTONG¿[CN]
Solicitantes
The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods
Resumen
thereof.
Alertas Tecnológicas
- 13 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
SELF-ASSEMBLED NANOSTRUCTURES
Nº publicación US2015031127A1 29/01/2015
STUPP SAMUEL I¿[US]
Solicitantes
RUFF YVES¿[US]
UNIV NORTHWESTERN¿[US]
The present disclosure is directed to the preparation of nanostructures
Resumen
by the encapsulation of a charged compound with individual
self-assembled unit nanostructures.
GLUCOSE-RESPONSIVE MICROGELS FOR CLOSED LOOP INSULIN DELIVERY
Nº publicación US2015030641A1 29/01/2015
MASSACHUSETTS INST TECHNOLOGY¿[US]
Solicitantes
Injectable insulin loaded microgels that are capable of modifying the
Resumen
amount of insulin released based on the patient's tissue glucose levels,
methods for making and using these compositions have been
developed. The microgels contain insulin, glucose oxidase entrapped
in or bound to the microgels, and an agent that reduces hydrogen
peroxide, entrapped in or bound to the microgels, wherein the
polymeric microgel expands when pH decreases from physiological
pH and shrinks when pH increases towards physiological pH, thereby
releasing insulin at a rate corresponding to the glucose concentration.
In one embodiment, the glucose oxidase and/or the agent reducing
hydrogen peroxide are encapsulated in nanogels, then encapsulated
within the microgel.
FORMULAS FOR DIAGNOSING AND TREATING HORMONE-DEPENDENT CANCERS AND CANCERS OF THE ORGANS
RESPONSIBLE FOR STEROID HORMONE SYNTHESIS
Nº publicación US2015030543A1 29/01/2015
COMMISSARIAT I EN ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES¿[FR]
Solicitantes
COMMISSARIAT L ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES¿[FR]
The present invention relates to a formula for a therapeutic agent or a diagnostic agent in the form of a nano-emulsion, a method
Resumen
for preparing said formula, and the use of this formula for treating or diagnosing hormone-dependent cancers and cancers of the
organs responsible for steroid hormone synthesis.
Alertas Tecnológicas
- 14 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES
Nº publicación US2015030541A1 29/01/2015
MALLINCKRODT LLC¿[US]
Solicitantes
The present invention provides phosphonate conjugates and methods
Resumen
of preparing the phosphonate conjugates so as to allow, for example,
improved methods and compounds for modifying the surface of a
nanoparticle to increase in vivo circulation times and targeted delivery
performance.
COMPOSITIONS AND METHODS FOR UPREGULATING HIPPOCAMPAL PLASTICITY AND HIPPOCAMPUS-DEPENDENT
LEARNING AND MEMORY
Nº publicación WO2015013451A2 29/01/2015
REVALESIO CORP¿[US]
Solicitantes
Provided are methods for enhancing hippocampal plasticity and hippocampal-mediated learning and memory, and/or enhancing
Resumen
the synaptic maturation of neurons, and/or optimizing or enhancing neuronal synaptic transmission, and/or enhancing intracellular
oxygen delivery or utilization, and/or enhancing ATP synthesis, comprising administration, to a subject in need thereof of a
sufficient amount over a sufficient time, of an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures (e.g.,
nanobubbles) having an average diameter of less than 100 nm (e.g., in at least one subject group selected from but not limited to
normal subjects, subjects recovering from neurological trauma (e.g., accidents or injury to the brain, stroke, oxygen deprivation,
drowning, and asphyxia), and subjects with learning disorders (e.g., dyslexia, dyscalculia, dysgraphia, dyspraxia (sensory
integration disorder), dysphasia/aphasia, auditory processing disorder, non-verbal learning disorder, visual processing disorder,
and attention deficit disorder (ADD)).
NANOEMULSIONS OF HYDROPHOBIC PLATINUM DERIVATIVE
Nº publicación WO2015013566A1 29/01/2015
NEMUCORE MEDICAL INNOVATIONS INC¿[US]
Solicitantes
GANTA SRINIVAS¿[US]
COLEMAN TIMOTHY P¿[US]
Provided are nanoemulsion formulations useful for the delivery of hydrophobic platinum chemotherapeutic drugs to cancer
Resumen
patients, as well as methods of their preparation and use.
Alertas Tecnológicas
- 15 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
FIBRIN HYDROGELS COMPRISING PLASMONIC NANOPARTICLES
Nº publicación ES2527800A1 29/01/2015
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PAZ FIBHULP¿[ES]
Solicitantes
CT DE INVESTIGACION BIOMEDICA EN RED EN BIOINGENIERIA BIOMATERIALES Y NANOMEDICINA CIBER
BBN¿[ES]
UNIV ZARAGOZA¿[ES]
The invention relates to a photothermal composition comprising a
Resumen
fibrin hydrogel matrix or a mixture of the precursors thereof, thrombin
and fibrinogen, in which hydrogel plasmonic nanoparticles and
heat-sensitive effectors are embedded, said effectors containing
therapeutic agents that are released by applying electromagnetic
radiation of a determined intensity and wavelength to the composition.
The photothermal composition is suitable for generating hyperthermia
in biological tissues in which said composition is implanted. The
invention therefore also relates to the use of the composition for the
destruction of tumours, the treatment of infections or the regeneration
of tissues, as well as for the controlled administration of therapeutic
agents.
Alertas Tecnológicas
- 16 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
CARRIER NANOPARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
Nº publicación US2015031832A1 29/01/2015
CALIFORNIA INST OF TECHN¿[US]
Solicitantes
Carrier nanoparticles comprising a polymer containing a polyol
Resumen
coupled to a polymer containing a boronic acid, configured to present
the polymer containing a boronic acid to an environment external to
the nanoparticle and related compositions, methods and systems.
Alertas Tecnológicas
- 17 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOCONJUGATES ABLE TO CROSS THE BLOOD-BRAIN BARRIER
Nº publicación US2015031745A1 29/01/2015
MIRKIN CHAD A¿[US]
Solicitantes
KO CAROLINE H¿[US]
STEGH ALEXANDER¿[US]
GILJOHANN DAVID A¿[US]
LUCIANO JANINA¿[US]
JENSEN SAMUEL A¿[US]
UNIV NORTHWESTERN¿[IL]
Polyvalent nanoconjugates address the critical challenges in
Resumen
therapeutic use. The single-entity, targeted therapeutic is able to cross
the blood-brain barrier (BBB) and is thus effective in the treatment of
central nervous system (CNS) disorders. Further, despite the
tremendously high cellular uptake of nanoconjugates, they exhibit no
toxicity in the cell types tested thus far. This property is critical for
therapeutic agent delivery applications for reducing off-target effects.
METHOD FOR PREPARING NANO PARTICLES
Nº publicación US2015031707A1 29/01/2015
BIO SYNECTICS INC¿[KR]
Solicitantes
The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the
Resumen
present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point
or glass transition temperature of 80 DEG C or lower and an active material, and mills the mixture using a roller mill, to thereby
prepare nano particle powder from the active material.
AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF
PREPARATION AND USES THEREOF
Nº publicación US2015031644A1 29/01/2015
UNIV SHANGHAI JIAOTONG¿[CN]
Solicitantes
The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods
Resumen
thereof.
Alertas Tecnológicas
- 18 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
SELF-ASSEMBLED NANOSTRUCTURES
Nº publicación US2015031127A1 29/01/2015
STUPP SAMUEL I¿[US]
Solicitantes
RUFF YVES¿[US]
UNIV NORTHWESTERN¿[US]
The present disclosure is directed to the preparation of nanostructures
Resumen
by the encapsulation of a charged compound with individual
self-assembled unit nanostructures.
GLUCOSE-RESPONSIVE MICROGELS FOR CLOSED LOOP INSULIN DELIVERY
Nº publicación US2015030641A1 29/01/2015
MASSACHUSETTS INST TECHNOLOGY¿[US]
Solicitantes
Injectable insulin loaded microgels that are capable of modifying the
Resumen
amount of insulin released based on the patient's tissue glucose levels,
methods for making and using these compositions have been
developed. The microgels contain insulin, glucose oxidase entrapped
in or bound to the microgels, and an agent that reduces hydrogen
peroxide, entrapped in or bound to the microgels, wherein the
polymeric microgel expands when pH decreases from physiological
pH and shrinks when pH increases towards physiological pH, thereby
releasing insulin at a rate corresponding to the glucose concentration.
In one embodiment, the glucose oxidase and/or the agent reducing
hydrogen peroxide are encapsulated in nanogels, then encapsulated
within the microgel.
FORMULAS FOR DIAGNOSING AND TREATING HORMONE-DEPENDENT CANCERS AND CANCERS OF THE ORGANS
RESPONSIBLE FOR STEROID HORMONE SYNTHESIS
Nº publicación US2015030543A1 29/01/2015
COMMISSARIAT I EN ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES¿[FR]
Solicitantes
COMMISSARIAT L ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES¿[FR]
The present invention relates to a formula for a therapeutic agent or a diagnostic agent in the form of a nano-emulsion, a method
Resumen
for preparing said formula, and the use of this formula for treating or diagnosing hormone-dependent cancers and cancers of the
organs responsible for steroid hormone synthesis.
Alertas Tecnológicas
- 19 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
EXOPOLYSACCHARIDE FOR THE TREATMENT AND/OR CARE OF THE SKIN, MUCOUS MEMBRANES AND/OR NAILS
Nº publicación EP2827837A2 28/01/2015
LUBRIZOL ADVANCED MAT INC¿[US]
Solicitantes
POLYMARIS BIOTECHNOLOGY¿[FR]
Exopolysaccharide of a bacterial strain for its use in treatment and/or care of the skin, mucous membranes, hair and/or nails, as
Resumen
well as its cosmetic and/or dermopharmaceutical compositions. In particular, for the aging of skin and in particular for the
treatment and/or prevention of wrinkles.
DUALLY DERIVATIZED CHITOSAN NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME FOR GENE
TRANSFER IN VIVO
Nº publicación EP2828332A1 28/01/2015
ENGENE INC¿[CA]
Solicitantes
Provided herein is chitosan dually derivatized with arginine and
Resumen
g l u c o n i c
a c i d
and methods of making and using the same, e.g., for gene delivery in
vivo.
Alertas Tecnológicas
- 20 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOASSEMBLED COMPLEXES OF NUCLEIC ACIDS, AVIDIN AND BIOTINYLATED COMPOUNDS FOR USE AS
CARRIERS FOR INTRACELLULAR DELIVERY
Nº publicación ITPD20130210A1 27/01/2015
ANANAS NANOTECH S R L
Solicitantes
It is herein described nanoassemblies of nucleic acids, avidin and
Resumen
biotinylated compounds for use as carriers for intracellular delivery.
These nanoassemblies are composed of central nuclei of polyavidins,
i.e. nuclei formed by a self- assembly of a plurality of tetrameric units
of avidin on nucleic acids, on which biotinylated compounds further
self-assemble by means of the high-affinity interactions between the
avidin of the central nucleus and the biotin of the biotinylated
compounds.
Alertas Tecnológicas
- 21 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
POLYMERISED CERIUM OXIDE NANOPARTICLES IN AN ACTIVE OR BIOACTIVE NETWORK, PROTECTIVE TOPICAL
TREATMENTS, METHODS FOR PREPARATION THEREOF AND USES THEREOF
Nº publicación FR3008700A1 23/01/2015
UNIV NICE SOPHIA ANTIPOLIS¿[FR]
Solicitantes
CENTRE NAT RECH SCIENT¿[FR]
The invention concerns a compound formed by functionalized microResumen
or nanoparticles associated covalently with rheology-modifying
polymers. The invention is characterized in that the functionalized
micro- or nanoparticles are functionalized micro- or nanoparticles of
cerium oxide (CeO2) having a nominal diameter of between 1 and
1500 nm. The rheology-adapting or -modifying polymers are selected
from among non-associative or associative polymers. The invention is
used in skin protection or decontamination.
METHODS OF THERAPEUTIC TREATMENT OF EYES
Nº publicación US2015024010A1 22/01/2015
REVALESIO CORP¿[US]
Solicitantes
Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous
Resumen
solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of
cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an
irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof
a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or
therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other
t h e r a p e u t i c
a g e n t s .
Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g.,
electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain
embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic
and/or therapeutic symptom related to eye conditions and/or diseases.
Alertas Tecnológicas
- 22 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
METHOD FOR PREPARING SOLID LIPID NANOPARTICLES CONTAINING ANTIBODIES IN ION PAIR FORM USING THE
FATTY ACID COACERVATION TECHNIQUE
Nº publicación WO2015007398A1 22/01/2015
FERBI SRL¿[IT]
Solicitantes
A method for preparing solid lipid nanoparticles containing antibodies, comprising the steps of: (a) preparing a micellar solution
Resumen
comprising: from 0.02 mg/ml to 10 mg/ml of at least one anionic surfactant selected from the group consisting of
alkylphosphates,
alkylsulfates
and
alkylsulfonates
from 0.1% to 30% by weight on the total weight of the micellar solution of at least one alkaline soap
from 0.1% to 30% by weight on the total weight of the micellar solution of at least one non-ionic amphiphilic polymer selected
from the group consisting of partially hydrolyzed polyvinyl acetate, polyoxyethylene/polyoxypropylene copolymers,
polyacrylamides, polyvinylpyrrolidone and derivatives thereof, dextrane derivatives and agarose derivatives with various
molecular weights, cellulose derivatives, non-ionic rubbers, cyclodextrins and derivatives thereof
said micellar solution being prepared by means of the following steps: (i) solubilizing in water the at least one anionic surfactant
(ii) adding the at least one alkaline soap, heating to a temperature comprised between 35 DEG C and 90 DEG C
and
(iii)
adding
the
at
least
one
non-ionic
amphiphilic
polymer
(b) adding to the micellar solution prepared in step (a) a solution that contains at least one antibody of interest at a concentration
comprised between 0.1 mg/ml and 10 mg/ml with respect to the final solution resulting from step (b)
(c) adding to the solution obtained in step (b) at least one acid at a concentration comprised between 0.01M and 5M with respect
to
the
final
solution
resulting
from
step
(c)
(d) cooling in an ice bath the suspension obtained in step (c) down to ambient temperature.
Modified Release Formulations Containing Drug - Ion Exchange Resin Complexes
Nº publicación US2015024059A1 22/01/2015
TRIS PHARMA INC¿[US]
Solicitantes
An aqueous liquid suspension containing a coated drug-ion exchange resin complex comprising a core composed of an
Resumen
amphetamine complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated amphetamine-ion exchange
resin complex is provided. The coated amphetamine-ion exchange resin complex is in admixture with a polymer to form a matrix.
Methods of making the coated complex and the liquid suspension are described.
Coated devices and methods for coating
Nº publicación US2015024206A1 22/01/2015
HANNOVER MED HOCHSCHULE¿[DE]
Solicitantes
The present invention relates in a first aspect to a method of coating
Resumen
surfaces of substrates with a lattice-like structure. In particular, the
present invention relates to an in vitro method of coating surfaces by
binding of epsin or a fragment thereof on the surface and, thereafter,
binding of a compound forming the lattice like structure, in particular,
binding of the clathrin heavy chain, to the epsin bound on the surface,
thus, obtaining a coated substrate having a lattice like structure on the
surface. In another aspect, the present invention relates to an in vitro
method of producing nanometer-sized liposomes having a clathrin
structure on its surface. In addition, substrates, like elements or
devices, with coated surfaces having a lattice-like structure on the
surface are provided obtainable by a method according to the present
invention.
Alertas Tecnológicas
- 23 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
APTAMER BIOCONJUGATE DRUG DELIVERY DEVICE
Nº publicación US2015025029A1 22/01/2015
ECOSYNTHETIX LTD¿[US]
Solicitantes
A delivery device for an active agent comprises nanoparticles based
Resumen
on a biopolymer such as starch. The delivery device may also be in the
form of an aptamer-biopolymer-active agent conjugate wherein the
aptamer targets the device for the treatment of specific disorders. The
nanoparticles may be made by applying a high shear force in the
presence of a crosslinker. The particles may be predominantly in the
range of 50-150 nm and form a colloidal dispersion of crosslinked
hydrogel particles in water. The biopolymer may be functionalized.
The aptamer may be conjugated directly to the cross-linked
biopolymers. The active agent may be a drug useful for the treatment
of cancer. The delivery device survives for a period of time in the
body sufficient to allow for the sustained release of a drug and for the
transportation and uptake of the conjugate into targeted cells.
However, the biopolymer is biocompatible and resorbable.
Alertas Tecnológicas
- 24 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
HYDROGEL VACCINE FORMULATIONS
Nº publicación AU2013285353A1 22/01/2015
SIGMOID PHARMA LTD
Solicitantes
This invention relates to compositions for delivering one or more
Resumen
active ingredients, and more particularly to compositions, e.g. beads,
comprising a matrix material which matrix material comprises a
microorganism. In particular, the invention relates to compositions
comprising a microorganism selected from live, killed, attenuated and
inactivated microorganisms. The matrix material may also comprise a
surfactant and may further comprise an adjuvant. The invention
further relates to the manufacture and use of such compositions, and to
other subject matter.
PAMAM DENDRIMER DERIVATIVES FOR ANTITHROMBOTIC THERAPY
Nº publicación WO2015008195A1 22/01/2015
FUNDACION FRAUNHOFER CHILE RES¿[CL]
Solicitantes
UNIV DE TALCA¿[CL]
The present invention is directed to nanoparticles with antithrombotic activity, more particularly, the nanoparticles are PAMAM
Resumen
dendrimers derivatives, which present low toxicity and high anticoagulant or antithrombotic activity. The invention also considers
methods for treating a condition wherein anticoagulation activities are needed.
METHODS OF THERAPEUTIC TREATMENT OF EYES
Nº publicación US2015024010A1 22/01/2015
REVALESIO CORP¿[US]
Solicitantes
Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous
Resumen
solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of
cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an
irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof
a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or
therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other
t h e r a p e u t i c
a g e n t s .
Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g.,
electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain
embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic
and/or therapeutic symptom related to eye conditions and/or diseases.
Alertas Tecnológicas
- 25 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
Modified Release Formulations Containing Drug - Ion Exchange Resin Complexes
Nº publicación US2015024059A1 22/01/2015
TRIS PHARMA INC¿[US]
Solicitantes
An aqueous liquid suspension containing a coated drug-ion exchange resin complex comprising a core composed of an
Resumen
amphetamine complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated amphetamine-ion exchange
resin complex is provided. The coated amphetamine-ion exchange resin complex is in admixture with a polymer to form a matrix.
Methods of making the coated complex and the liquid suspension are described.
Coated devices and methods for coating
Nº publicación US2015024206A1 22/01/2015
HANNOVER MED HOCHSCHULE¿[DE]
Solicitantes
The present invention relates in a first aspect to a method of coating
Resumen
surfaces of substrates with a lattice-like structure. In particular, the
present invention relates to an in vitro method of coating surfaces by
binding of epsin or a fragment thereof on the surface and, thereafter,
binding of a compound forming the lattice like structure, in particular,
binding of the clathrin heavy chain, to the epsin bound on the surface,
thus, obtaining a coated substrate having a lattice like structure on the
surface. In another aspect, the present invention relates to an in vitro
method of producing nanometer-sized liposomes having a clathrin
structure on its surface. In addition, substrates, like elements or
devices, with coated surfaces having a lattice-like structure on the
surface are provided obtainable by a method according to the present
invention.
Alertas Tecnológicas
- 26 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
APTAMER BIOCONJUGATE DRUG DELIVERY DEVICE
Nº publicación US2015025029A1 22/01/2015
ECOSYNTHETIX LTD¿[US]
Solicitantes
A delivery device for an active agent comprises nanoparticles based
Resumen
on a biopolymer such as starch. The delivery device may also be in the
form of an aptamer-biopolymer-active agent conjugate wherein the
aptamer targets the device for the treatment of specific disorders. The
nanoparticles may be made by applying a high shear force in the
presence of a crosslinker. The particles may be predominantly in the
range of 50-150 nm and form a colloidal dispersion of crosslinked
hydrogel particles in water. The biopolymer may be functionalized.
The aptamer may be conjugated directly to the cross-linked
biopolymers. The active agent may be a drug useful for the treatment
of cancer. The delivery device survives for a period of time in the
body sufficient to allow for the sustained release of a drug and for the
transportation and uptake of the conjugate into targeted cells.
However, the biopolymer is biocompatible and resorbable.
PAMAM DENDRIMER DERIVATIVES FOR ANTITHROMBOTIC THERAPY
Nº publicación WO2015008195A1 22/01/2015
FUNDACION FRAUNHOFER CHILE RES¿[CL]
Solicitantes
UNIV DE TALCA¿[CL]
The present invention is directed to nanoparticles with antithrombotic activity, more particularly, the nanoparticles are PAMAM
Resumen
dendrimers derivatives, which present low toxicity and high anticoagulant or antithrombotic activity. The invention also considers
methods for treating a condition wherein anticoagulation activities are needed.
Alertas Tecnológicas
- 27 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
HYDROGEL VACCINE FORMULATIONS
Nº publicación AU2013285353A1 22/01/2015
SIGMOID PHARMA LTD
Solicitantes
This invention relates to compositions for delivering one or more
Resumen
active ingredients, and more particularly to compositions, e.g. beads,
comprising a matrix material which matrix material comprises a
microorganism. In particular, the invention relates to compositions
comprising a microorganism selected from live, killed, attenuated and
inactivated microorganisms. The matrix material may also comprise a
surfactant and may further comprise an adjuvant. The invention
further relates to the manufacture and use of such compositions, and to
other subject matter.
DRUG DELIVERY CONJUGATE CAPABLE OF CONTROLLED RELEASE, AND USE THEREOF
Nº publicación EP2826492A1 21/01/2015
POSTECH ACAD IND FOUND¿[KR]
Solicitantes
KYUNGPOOK NAT UNIV IND ACAD¿[KR]
The present invention relates to a hydrophobic drug delivery conjugate, to which cyclodextrin, poly(maleic anhydride), and a
Resumen
hydrophobic drug are bonded, and to a pharmaceutical composition comprising the hydrophobic drug delivery conjugate as an
active ingredient. The hydrophobic drug delivery conjugate according to the present invention can effectively control the release
rate and the delivery rate of a hydrophobic drug by regulating the physicochemical bonding and/or composition of the
cyclodextrin, poly(maleic anhydride), and hydrophobic drug, and can also increase the effect of the drug by significantly
increasing the solubility of the hydrophobic drug. Further, the present invention can enable the type of the hydrophobic drug to be
varied, as well as a peptide having target directivity to be introduced into a surface of the conjugate, such that the present
invention can be applied to the treatment of various diseases in addition to cancer treatment.
Alertas Tecnológicas
- 28 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
METHOD FOR PREPARING SOLID LIPID NANOPARTICLES CONTAINING ANTIBODIES IN ION PAIR FORM USING THE
FATTY ACID COACERVATION TECHNIQUE
Nº publicación ITBO20130376A1 19/01/2015
FERBI SRL
Solicitantes
A method for preparing solid lipid nanoparticles containing antibodies, comprising the steps of: (a) preparing a micellar solution
Resumen
comprising: from 0.02 mg/ml to 10 mg/ml of at least one anionic surfactant selected from the group consisting of
alkylphosphates,
alkylsulfates
and
alkylsulfonates
from 0.1% to 30% by weight on the total weight of the micellar solution of at least one alkaline soap
from 0.1% to 30% by weight on the total weight of the micellar solution of at least one non-ionic amphiphilic polymer selected
from the group consisting of partially hydrolyzed polyvinyl acetate, polyoxyethylene/polyoxypropylene copolymers,
polyacrylamides, polyvinylpyrrolidone and derivatives thereof, dextrane derivatives and agarose derivatives with various
molecular weights, cellulose derivatives, non-ionic rubbers, cyclodextrins and derivatives thereof
said micellar solution being prepared by means of the following steps: (i) solubilizing in water the at least one anionic surfactant
(ii) adding the at least one alkaline soap, heating to a temperature comprised between 35 DEG C and 90 DEG C
and
(iii)
adding
the
at
least
one
non-ionic
amphiphilic
polymer
(b) adding to the micellar solution prepared in step (a) a solution that contains at least one antibody of interest at a concentration
comprised between 0.1 mg/ml and 10 mg/ml with respect to the final solution resulting from step (b)
(c) adding to the solution obtained in step (b) at least one acid at a concentration comprised between 0.01M and 5M with respect
to
the
final
solution
resulting
from
step
(c)
(d) cooling in an ice bath the suspension obtained in step (c) down to ambient temperature.
PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY
Nº publicación WO2015006429A1 15/01/2015
US HEALTH¿[US]
Solicitantes
BAYLOR COLLEGE MEDICINE¿[US]
Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the
Resumen
nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include
a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa- 10,12diynoyl)-sn-glycero-3-phosphocholine
(DC8,9PC),
dipalmitoylphosphatidylcholine
(DPPC),
and
(ii)
2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an
agent within the cavity.
LIPID-CONTAINING NANOPARTICLE
Nº publicación WO2015004466A1 15/01/2015
UNIV ASTON¿[GB]
Solicitantes
A lipid-containing nanoparticle, the nanoparticle comprising: a membrane-forming polar lipid
Resumen
and a lipid- solubilising agent including a synthetic amphipathic polymer which is a copolymer of a first monomer of formula:
where R1 and R2 are each independently hydrogen or C1 - C9 alkyl, and at least one of R3 and R4 is C1 - C9 alkyl and the other
is
hydrogen
or
C1
C9
alkyl
and a second monomer of formula R5-CH=CH2 where R5 is selected from hydrogen, C1-C8 alkyl, C1-C6 alkoxy, phenyl, benzyl
and phenyl or benzyl substituted with an alkyl or other hydrophobic group and uses of this in contact lens applications and
membrane extraction
Targeted active release system comprising solid lipid nano-particles
Nº publicación WO2015004045A1 15/01/2015
OTC GMBH¿[DE]
Solicitantes
The present invention relates to lamellar encapsulated nano-particles comprising at least one liquid crystalline emulsifier
Resumen
membrane around an inner core, wherein the inner core is solid below 30 DEG C and comprises at least one substance selected
from the group consisting of lipids, waxes and/or polymeric substances, wherein the particle size is 100 nm and 800 nm and the
average packing parameter of the emulsifier in the liquid crystalline membrane is 0.3 and 0.9.
Targeted active release system comprising solid lipid nano-particles
Nº publicación EP2823811A1 14/01/2015
OTC GMBH¿[DE]
Solicitantes
The present invention relates to lamellar encapsulated nano-particles comprising at least one liquid crystalline emulsifier
Resumen
membrane around an inner core, wherein the inner core is solid below 30 DEG C and comprises at least one substance selected
from the group consisting of lipids, waxes and/or polymeric substances, wherein the particle size is 100 nm and 800 nm and the
average packing parameter of the emulsifier in the liquid crystalline membrane is 0.3 and 0.9.
Alertas Tecnológicas
- 29 de 30 -
NANOFÁRMACOS
Departamento de Patentes e Información Tecnológica
Unidad de Información Tecnológica
NANOCRYSTALLINE SOLID DISPERSION COMPOSITIONS AND PROCESS OF PREPARATION THEREOF
Nº publicación EP2822539A2 14/01/2015
NAT INST OF PHARMACEUTICAL EDUCATION AND RES NIPER¿[IN]
Solicitantes
The present invention relates to nanocrystalline solid dispersion
Resumen
compositions having discrete particles, wherein each discrete particle
comprises crystals of at least one pharmaceutical active
veterinary
active
nutraceutical active dispersed in the matrix of at least one
crystallization inducer and/or coexisting with crystals of
crystallization inducer, optionally along with pharmaceutically
acceptable excipients. The present invention also encompasses a novel
one-step process for generation of nanocrystalline solid dispersions.
The present invention is particularly of use for improving the
dissolution of pharmaceutical actives, veterinary actives
nutraceutical actives exhibiting dissolution-limited bioavailability.
Dissolution enhancement is because of the decreased crystallite size of
the pharmaceutical active.
Alertas Tecnológicas
- 30 de 30 -
NANOFÁRMACOS