1. Ciencia

111
REFERENCES
1.
Ray, A., “Cancer preventive role of selected dietary factors,” Ind J Cancer., 42(1),
pp.15-24, 2005.
2.
Abercrombie, M., and Ambrose, E.J., “The Surface Properties of Cancer Cells: A
Review,” Cancer Res., 22, pp. 525-548, 1962.
3.
Eisenhauer, E. A., Therasse, P., Bogaert, J., Schwartz, L.H., Sargent, D., Ford, R,J.,
Dancey, S., Arbuck, S., Gwyther, M., Mooney, L., Rubinstein, L., Shankar, L.,
Dodd, R., Kaplan, D., Lacombe, J., Verweij., A., “ New response evaluation criteria
in solid tumours:Revised RECIST guideline,” European Journal of Cancer.,45, pp.
228–247, 2009.
4.
Anand, P., Kunnumakara, A. B., Sundaram, C., Harikumar, K. B., Tharakan, T. S.,
Lai, O. S., Sung, O., and Aggarwal, B. B., “Cancer is a Preventable Disease that
Requires Major Lifestyle Changes,” Pharm Res., 25(9), pp. 2097–2116, 2008.
5.
Aikins, A. G., Boynton, P., and Atanga. L. L., “Developing effective chronic
disease interventions in Africa: insights from Ghana and Cameroon,” Globalization
and Health., 6(6), 2010.
6.
Jemal, A., Center, M. M., DeSantis, C., and Ward, E.M.,“ Global Patterns of
Cancer Incidence and Mortality Rates and Trends,” Cancer Epidemiol Biomarkers
Prev.,19, pp. 1893-1907, 2010.
7.
Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., Parkin, D.M., “Estimates
of worldwide burden of cancer in 2008: GLOBOCAN 2008,” Int J Cancer., 27(12),
pp 2893-2917, 2010.
8.
Ridge, J, A., Glisson, B. S., Lango, M. N., “Head and Neck Tumors" in Pazdur, R,
Wagman, L.D, Camphausen, K.A, Hoskins, W.J., (Eds) Cancer Management: A
Multidisciplinary Approach. 11 ed. 2008.
9.
Latifi, H., Mikaili, P., Latifi, K., Torbati, H., “Squamous cell carcinoma of larynx
in northwestern Iran.” European Journal of Experimental Biology, 2 (1), pp. 242246, 2012.
10. Daly, M. E., Le, Q. T., Jain, A. K, Maxim, P. G., Hsu, A., Loo, B. W. Jr, Kaplan,
M. J., Fischbein, N. J., Colevas, A. D., Pinto, H., Chang, D.T., “Intensitymodulated radiotherapy for locally advanced cancers of the larynx and
hypopharynx,” Head Neck .,33, pp. 103-111, 2011.
112
11. Chadha, S., Gupta, B., Jatwani, S., Gulati, A., “A study of patient factors and tumor
characteristics in malignancy of larynx: A tertiary care center experience,” Journal
of Laryngol Voice., 1, pp. 79-80, 2011.
12. Ali, I., Wani, W. A., and Saleem, K., “Cancer Scenario in India with Future
Perspectives,” Cancer Therapy, 9, pp. 56-70, 2011.
13. Cordero, M., Borbón, H., Román, F. R., Víquez, R., Villegas, L.R., Soto, R., Vega,
I., and Herrera, J. M., “Antimicrobial Activity and Phytochemical Screening of
Secondary Metabolites Extracted from the Ascidian rhopalaea Birkelandi, “
European
Journal of Scientific Research, 70(3), pp.345-353,2012.
14. Geoffrey A. Cordell., “ Pharmacognosy A High tech Pharmaceutical Science,”
Pharmacia JTPA, 30(3), pp. 169-181,1990.
15. Wilkinson, E. J., and Teixeira, M. R., “Epithelial tumours, squamous tumours,” in
World Health Organisation, Classification of Tumours: Pathology and Genetics:
Tumours of the Breast and Female Genital Organs,” 270, pp. 316–320, IARC Press
Lyon, France, 2003.
16. Boivin, D., Lamy, S., Dufour, S. L., Jackson, J., Beaulieu, E., Cotec, M., Moghrabi,
A., Barrette, S., Gingras, D., Béliveau, R.,” Antiproliferative and antioxidant
activities of common vegetables: A comparative study,” Food Chemistry, 112, pp.
374–380, 2009.
17. Farag, M. A., and Motaal, A. A., “Sulforaphane composition, cytotoxic and
antioxidant activity of crucifer vegetables,” Journal of Advanced Research, 1, pp.
65–70, 2010.
18. Thornalley, P. J., “Isothiocyanates: mechanism of cancer chemopreventive Action,”
Anti Cancer Drugs, 13, pp. 331–338, 2002.
19. Devi, P. U., Akagi, K., Ostapenko, V., Tanaka, Y., Sugahara, T., “Withaferin A: a
new radiosensitizer from the Indian medicinal plant Withania somnifera,” Int J
Radiat Biol, 69, pp. 193-197,1996.
20. Verhoeven, D. T. H., Verhagen, H., Goldbohm, R. A., Brandtb, P. A., Poppel, G.
A., “ A review of mechanisms underlying anticarcinogenicity by brassica
vegetables,” Chemico-Biological Interactions., 103, pp 79- 129,1997.
21. Dias, J. S., “Nutritional quality and Health benefits of Vegetables A Review,” Food
and Nutrition Sciences, 3, pp. 1354-1374, 2012.
22. Dekker, M., Hennig, K., and Verkerk, R “ Differences in Thermal Stability of
Glucosinolates in Five Brassica Vegetables,” Czech J. Food Sci, 27, pp. 83-88,
2009.
113
23. Meyer, M., and Adam, S. T., “Comparison of glucosinolate levels in commercial
broccoli and Brassica oleraceae from conventional and ecological farming,” Eur
Food Res. Technol., 228, pp. 1429-1437, 2008.
24. Fahey, J. W., Zalcmann, A. T., Talalay, P., “The chemical diversity and distribution
of glucosinolates and isothiocyanates among plants,” Phytochemistry, 56, pp. 5-51,
2001.
25. Rosa, E. A. S., Heaney, R. K., Fenwick, G. R., Portas, C. A. M., “Glucosinolates in
crop plants,” Hortic Rev, 19, pp. 99-215, 1997.
26. Keck, A. S., Finley, J. W., “Cruciferous vegetables: Cancer protective mechanisms
of glucosinolate hydrolysis products and selenium,” Integr Cancer Ther, 3, pp 5-12,
2004.
27. Mosbah, A.F.B., Kushad, M., Kurilich Anne, C., Juvik John, A., Klein Barbara, P.,
Wallig Mathew, A., Jeffrey Elizabeth, H., “Variation of glucosinolates in vegetable
crops of Brassica oleraceae,” J. Agric. Food Chem, 47, pp. 1541–1548, 1999.
28. Mithen, R., “Glucosinolates - biochemistry, genetics and biological activity,” Plant
Growth Regulation, 34, pp. 91–103, 2001.
29. Rouzaud, G., Rabot, S., Ratcliffe, B., Duncan, A.J., “Influence of plant and
bacterial myrosinase activity on the metabolic fate of glucosinolates in gnotobiotic
rats,” Br J Nutr., 90(2), pp. 395-404, 2003.
30. Higdon, J. V., Delage, B., Williams, D. E., and Dashwood, R. H., “Cruciferous
Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic
Basis,” Pharmacol Res, 55(3), pp 224–236, 2007.
31. Wu, X., Kassie, F., Sundermaann, V.S., “Induction of apoptosis by naturally
occurring sulphur containing compounds,” Mutation Research, 589, pp.81-102,
2005.
32. Xiao, D., Kew, K. L., Zeng, Y., Xiao, H., Stanley, W., Singh, S.V., Dhir, R.,
“Phenethyl isothiocyanates induces apoptosis in Prostate cancer cells is mediated
by reactive oxygen species in mediated by mitochondrial membrane disruption
potential,” Carcinogenesis, 27(11), pp. 223-2234, 2006.
33. Toraskar, M. P., Kulkarni, V. M., Dhanashire, S. T., Kadam, V. J., “Isothiocyanate:
cancer chemopreventive agent,” Journal of Pharmacy Research, 2(10), pp.16381641, 2009.
34. Stephen, H. S., “Inhibition of carcinogenesis by lsothiocyanates,” Drug Metabolism
Reviews, 32, pp. 395-411, 2007.
114
35. Clarke, J. D., Dashwood, R. H., and Ho, E., “Multi-targeted prevention of cancer by
sulforaphane,” Cancer Lett, 269(2), pp. 291–304., 2008.
36. Chung, F.L., Conaway, C.C., Rao, C.V., Reddy, B.S., “Chemoprevention of colonic
aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate,”
Carcinogenesis, 21(12), pp. 2287-2291, 2000.
37. Michaud, D. S., Spiegelman, D., Clinton, S. K., Rimm, E. B., Willett, W. C., and
Giovannucci, E. L., “Fruit and vegetable intake and incidence of bladder cancer in a
male prospective cohort,” J Natl Cancer Inst, 91(7), pp. 605-613,1999.
38. Smith-Warner S. A., Spiegelman, D., Yaun, S. S., Adami, H. O., Beeson, W. L.,
“Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of
cohort studies,” JAMA, 285, pp.769–776, 2001.
39. Bjorkman, M, Klingen, I., Birch, A.N., Bones, A.M., Bruce, T.J., Johansen, T.J.,
Meadow, R., Molmann, J., Seljasen, R., Smart, L.E., Stewart, D., “Phytochemicals
of Brassicaceae in plant protection and human health--influences of climate,
environment and agronomic practice,” Phytochemistry, 72(7), pp.538-556, 2011.
40. Tanchev, S. S., Timberlake, C. F., “The anthocyanins of Brassica oleraceae,”
Phytochemistry, 8(9), pp. 1825-1827, 1969.
41. Zhao, C., Giuisti, M. M., Malik, M., Moyer, M. P., Magnon, B. A., “Effects of
anthocyanin rich extracts on colonic cancer nontumourigenic colon cell growth,”
Journal of Agricultural Food Chemistry, 52(20), pp. 6122-6128, 2004.
42. Ambrosone, C. B., and Tang, L., “Cruciferous vegetable intake and cancer
prevention: role of nutrigenetics,” Cancer Prev Res, 2(4), pp. 298-300, 2009.
43. Timberlake, C. F. And Bridle, P. eds. J. B. Harborne, T. Mabry, and H.
Mabry,(1973) “ The Anthocyanins,” In The Flavonoids, Academic Press, New
York, pp. 215-266.
44. Dai, J., and Mumper, R. J., “Plant Phenolics: Extraction, Analysis and Their
Antioxidant and Anticancer Properties,” Molecules, 15, pp.7313-7352, 2010.
45. Vidhrih, R., FIlip, S., Hribar, J.,” Content of Higher fatty acid in Green vegetables,”
Czech J Food Sci, 27, pp. 125-129, 2009.
46. Liou Y.A., King, D. J., Zibrik, D., Innis, S.M., “Decreasing linoleic acid with
constant α –linoleic acid in dietary fat increases eicosapentanoic acid in plasma
phospholipids in healthy men,” Journal of Nutrition,13, pp.945-952, 2007.
115
47. Rosenbluth, J. M., Mays, D. J., Pino, M. F., Tang, L. J., and Pietenpol, J. A.,
“A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73,” Mol
Cell Biol, 28(19), pp. 5951–5964, 2008.
48. Moore, A. E., Sabachewsky, L., and Toolan, H. W., “Culture characteristics of four
permanent lines of human cancer cells,” Cancer Res., 15, pp. 598-602, 1955.
49. Toolan, H., “Transplantable human neoplasms maintained in cortisone treated
laboratory animals,” Cancer Res, 14, pp. 660-666, 1954.
50. Moore, A. E., “Oncolytic properties of viruses,” Tex Rep Biol Med, 15, pp. 588599, 1957.
51. Moore, A. E., “Tumorigenic activity of cultures,” ANN NY Acad Sci, 76, pp. 497505, 1958.
52. Paul, J., and Mike, T., “How cells coordinate growth and division, “Current
Biology,” 14, 23 pp. 1014-1027, 2004.
53. Mitchison, J, M, (1971) “The biology of cell cycle,” Cambridge University press,
New York.
54. Collins, K., Jacks, T., and Pavletich, N. P., “The cell cycle and cancer,” PNAS, 94 (
7), pp. 2776-2778, 1997.
55. Raff, M., “Cell suicide for beginners.” Nature, 396, pp. 119-122, 1998.
56. Adrain, C., Creagh, E. M., and Martin, S. J., (2002), Caspase Cascades in
Apoptosis. Caspases-their role in cell death and cell survival Ed. Marek Los and
Henning Walczak, Moleculare Biology Intelligence Unit 24, New York, pp. 41-51.
57. Hague, A., and Paraskeva, C., “Apoptosis and disease: a matter of cell fate,” Nature
Cell Death and Differentiation, 3, pp. 1-7, 2004.
58. Wang, Z., and Sun, Y., “Targeting p53 for Novel Anticancer Therapy,” Transl
Oncol., 3(1), pp. 1–12, 2010.
59. Levine, B., and Abrams, J., “p53: the Janus of autophagy,” Cell Biol, 10(6), pp.
637–639, 2008.
60. Buzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao,
F., Viollet, B., Thompson, C, B.,“ Systemic treatment with the anti diabetic drug
metformin selectively impairs p53-deficient tumor cell growth,” Cancer
Res,.67(14), pp. 6745–6752, 2007.
116
61. Wahl, G. F., & Carr, A.M., “ The evolution of diverse biological responses to DNA
damage: insights from yeast and p53,” Nature Cell Biology, 3, pp. 277 – 286,2001.
62. Lowe, S. W., and Lin, A.W., “Apoptosis in cancer,” Carcinogenesis, 21 (3), pp.
485-495, 2000.
63. Kasibhatla, S., and Tseng, B., “Why Target Apoptosis in Cancer Treatment?,” Mol
Cancer Ther, 2, 573, 2003.
64. Elkholi, A., Floros, K. V., and Chipuk., J. E., “ The Role of BH3-Only Proteins in
Tumor Cell Development, Signalling, and Treatment,” Genes & Cancer, 2 (5), pp.
523-537, 2011.
65. Lomonosova, E., and Chinnadurai, G., “BH3-only proteins in apoptosis and
beyond: an overview,” Oncogene, 27(1), pp. 2–19, 2008.
66. Deveraux, Q. L., and Reed, J. C., “IAP family proteins—suppressors of apoptosis,”
Genes & Dev, 13, pp. 239-252, 1999.
67. Elmore, S., “Apoptosis: A Review of Programmed Cell Death,” Toxicol Pathol, 35,
pp. 4495-4516, 2007.
68. Gross, A., McDonnell, J. M., and Korsmeyer, S. J., “Bcl-2 family members and the
mitochondria in apoptosis,” Genes & Dev, 13, pp. 1899-1991,1999.
69. Lee, Y. J., and Lee, S. H., “Sulforaphane Induces Antioxidative and
Antiproliferative Responses by Generating Reactive Oxygen Species in Human
Bronchial Epithelial BEAS-2B Cells,” J Korean Med Sci., 26(11), pp. 1474–1482,
2011.
70. Amaral, C., Borges, M., Melo, S., DaSilva, E. T., DaSilva, G.C., Teixeira, N.,
“Apoptosis and Autophagy in Breast Cancer Cells following Exemestane
Treatment,” PLoS ONE., 7(8), e42398, 2012.
71. Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Arencibia, M. G., Thompson,
Z. W., Sanchez, M. J., Korolchuk, V. I., Lichtenberg, M., Luo, S., .Massey, D. C.,
Menzies, F. M., Moreau, K., Narayanan, U., Renna, M., Siddiqi, F. H., Benjamin,
R, U., Winslow, A.R. and Rubinszteinnan, D.C., “Regulation of Mammalian
Autophagy in Physiology and Pathophysiology,” Physiol Rev., 90( 4), pp. 13831343, 2010.
72. Shen, H., Yu, H., .Liang, P. H., Cheng, H., XuFeng, R., Yuan, Y., Zhang, P.,
Smith,C. A., and Tao Cheng, A., “An acute negative bystander effect of γ-irradiated
recipients on transplanted hematopoietic stem cells,” Blood, 119 (15 ), pp. 36293637, 2012.
117
73. Kombairaju, P., Ma, J., Thimmulappa, R.K., Yan, S., Gabrielson, E., Singh, A.,
Biswal, S., “Prolonged sulforaphane treatment does not enhance tumorigenesis in
oncogenic K-ras and xenograft mouse models of lung cancer,” J Carcinog, 11(8),
2012.
74. Myzak, M. C., Hardin, K., Wang, R., Dashwood, R. H., Ho, E., “Sulforaphane
inhibits histone deacetylase activity in bph-1, lncap and pc-3 prostate epithelial
cells,” Carcinogenesis, 27, pp. 811–819, 2006.
75. Townsend, D.M, and Tew, K.D., “The role of glutathione-S-transferase in anticancer drug resistance,” Oncogene, 22, pp. 7369–7375, 2003.
76. Gunnarsdoittr, S., and Elfarra, S., “GST’s as prodrugs,” J Pharmacol Exp
Therapeutics, 20, pp. 50-957, 1999.
77. Faden, M. C., Melwin, W. T., and Murray, G. I. “Cytochrome P450 enzymes: a
novel option for cancer therapeutics,” Mol Can Therapeutics, 3(3), pp. 363-371,
2004.
78. Josephy, P. D., “Genetic Variations in Human Glutathione Transferase Enzymes:
Significance for Pharmacology and Toxicology,” Hum Genomics Proteomics, pp.
876-940, 2010.
79. Thimmulappa, R. K., Mai, K.H., Srisuma, S., Kensler, T. W., Yamamoto, M., and
Biswal, S., “Identification of Nrf2-regulated Genes Induced by the
Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray,” Cancer
Research, 62, pp. 5196-5203, 2002.
80. Ribic, C. M., Sargent, D. J., Moore, M. J., "Tumor microsatellite-instability status
as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon
cancer". N. Engl. J. Med, 349 (3), pp. 247–257, 2003.
81. Joerger, A. C., and Fersht, A.R., “The Tumor Suppressor p53: From Structures to
Drug Discovery,” Cold Spring Harb Perspect Biol, 2(6), a000919, 2010.
82. Prakash, N., Patel, S., Fadul, N. J., Ranjan, R., Sudheer, D.V.N., “Molecular
docking studies of Antimalarial drugs for Malaria,” 3, pp.70-73, 2010.
83. Baskaran, C, Radhabai, V., Kumaran, K., Kumar, K.M., “Computer aided Drug
designing for EGFR receptor for Lung cancer,” Annals of Biological Research,
3(4), pp.1815-1820, 2012.
84. Shapiro, T. A., Fahey, J. W., Dinkova-Kostova, A. T., Holtzclaw, W.D,
Stephenson, K. K. “Safety, tolerance and metabolism of broccoli sprout
glucosinolates and isothiocyanates: a clinical phase I study,” Nutr Cancer, 55, pp.
53-62, 2006.
118
85. Fahey, J. W., Haristoy, X,
Dolan, P. M., Kensle, T. W., Scholtus, I.,
Stephenson, K. K., Talalay, P., and Lozniewski, A., “Sulforaphane inhibits
extracellular, intracellular and antibiotic-resistant strains of Helicobacter pylori and
prevents benzo[a]pyrene induced stomach tumors,” PNAS., 99, pp. 7610-7615,
2002.
86. Halkier, B. A., (1999), Glucosinolates In: Ikan, R.(Ed.), Naturally Occurring
Glycosides: Chemistry, Distribution and Biological Properties, John Wiley &
Sons, pp. 193–223.
87. Wu, X., Beecher, G. R, Holden, J. M., Haydowitz, D.B., Gebhardt, S.B.,
“Concentration of anthocyanins in common food of United States,” Journal of
Agricultural and Food chemistry, 54(11), pp. 4069-4075, 2006.
88. Dyrby, M., Westergard, N., Stapelfeldt, H., “Light and heat sensitivity of Brassica
oleraceae extract in soft drink model system,” Food chemistry, 72(4), pp. 431-437,
2001.
89. Doughall, G.J., Fyffe, S., Dobson, P., Stewart, D., “Anthocyanins from Brassica
oleraceae stability to simulated gastrointestinal digestion,” Phytochemistry, 68(9),
pp. 1285-1294, 2007.
90. Hagiwara, A , Yoshidho, H., Icihara, T., Kawabe, M., Tamano, S., Aoki, H., Koda,
T., Nakamura, M., Imaida, K., Ito, N., Shirai, T., “ Prevention by natural food
anthocyanins, Purple sweet potato and Brassica oleraceae color of 2 amino 1
methyl-6- phenylimidazo [4,5b] pyridine PhIP associated colorectal carcinogenesis
in rats initiated with 1,2 dimethylhydrazine, Journal of Toxicological Science,
27(1), pp. 57-68, 2002.
91. Kim, Y. S., Milner, J. A., “Targets for indole-3-carbinol in cancer prevention.
Journal of Nutritional Biochemistry,” 16, pp. 65–73, 2005.
92. Steven, J., Jackson, T., Singletary, K.W, “Sulforaphane: a naturally occurring
mammary carcinoma mitotic inhibitor which disrupts tubulin polymerization,”
Carcinogenesis, 25 pp. 219-227, 2004.
93. Agudo, A., Ibanez, R, Amiano, P., Ardanaz, E., Barricarte, A.,“Consumption of
cruciferous vegetables and glucosinolates in a Spanish adult population,”. Eur J
Clin Nutr , 62, pp. 324-331, 2004.
94. Kim, J. H, Durrett, T. P, Last, R. L., Jander, G., “Characterization of the
Arabidopsis TU8glucosinolate mutation, an allele of TERMINAL FLOWER2,”
Plant Mol Biol, 54, pp. 671-682, 2004.
119
95. Zhou, J., Hu, J., Qiu, A., “Separation and purification of the main glucosinolate
from rapeseeds,” Se Pu, 23, pp. 411-414, 2005.
96. Barillari, J., Cervellati, R., Paolini, M., Tatibouet, A., Rollin, P, Iori,R., “Isolation
of 4methylthio-3-butenyl glucosinolate from Raphanus sativus sprouts (kaiware
daikon) and its redox properties,” J. Agric Food Chem, 53, pp. 9890-9896, 2005.
97. McNaughton, S. A., and Marks, G.C., “Development of a food composition
database for the estimation of dietary intakes of glucosinolates, the biologically
active constituents of Cruciferous vegetables,” British Journal of Nutrition, 90, pp.
687–697, 2003.
98. Steinkellner, H., Rabot, S., Freywald, C., Nobis, E., Scharf, G., Chabicovsky,
M., , Knasmüller, S., Kassie, F., “Effects of cruciferous vegetables and their
constituents on drug metabolizing enzymes involved in the bioactivation of DNAreactive dietary carcinogens,” Mutat Res, 1(480-481), pp.285-297, 2001.
99. Aires, A., Mota, V. R., Saavedra, M. J., Rosa, E. A., Bennett, R. N.,” The
antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis
products on bacteria isolated from the human intestinal tract,” J Appl Microbiol,
106, pp. 2086-2095,2009.
100.Murillo, G., & Mehta, R. G., “Cruciferous Vegetables and Cancer
Nutrition and Cancer, 41(1-2), pp. 17-28, 2001.
prevention,”
101.Xavier, M, F., Lopes, T. J., Quadri, M. G., Quadri, M. B., “Extraction of Red
cabbage Anthocyanins: Optimization of the operation conditions of the column
process,” Brazilian archives of Biology and technology, 51, pp. 143-152, 2008.
102.Bjerg, B., Sorensen, H., “Glucosinolates in Rapeseeds, Analytical Aspects,” in
Proc. CEC Workshop, Gembloux, Belgium, 1986.
103.Björkqvist, B., “Separation and determination of intact glucosinolates in rapeseed
by high-performance liquid chromatography,” Journal of Chromatography A, 435,
pp. 501–507, 1988.
104.Ciska, E., Kozlowska, H., “The effect of cooking on the glucosinolates content in
white cabbage,” Eur Food Res Technol,212(5), pp.582–587,2001
105.Visentin, M., Tava, A., Iori, R., Palmieri, S., “Isolation and identification for trans4-(methylthio)-3-butenyl glucosinolate from radish roots (Raphanus sativus L),” J.
Agric. Food Chem., 40 (9), pp. 1687–1691, 1992.
106.Fahey, J. W., Wade, K. L., Stephenson, K. K., Chou, E., “Separation and
purification of glucosinolates from crude plant homogenates by high-speed counter-
120
current chromatography,” Journal of Chromatography A , 996(1–2), pp 85–93,
2003.
107.Minchinton, I., Sang, J., Burke, D., Truscott, R. J. W., “Separation of
desulphoglucosinolates
by
reversed-phase
high-performance
liquid
chromatography,” Journal of Chromatography, 247, pp. 141-148, 1982.
108.Kaushik, N., and
Agnihotri, A., “High-performance liquid chromatographic
method for separation and quantification of intact glucosinolates,”
Chromatographia, 49(5, 6), pp. 281-284, 1999.
109.Kiddle, G., Bennett, R. N., Botting, N.P., Davidson, N.E., Robertson, A.B.,
Wallsgrove, R.M., “High-performance liquid chromatographic separation of natural
and synthetic desulphoglucosinolates and their chemical validation by UV, NMR
and chemical ionisation-MS methods,” Phytochemical Analysis, 12(4), pp. 226–
242, 2001.
110.Kliebenstein, D. J., Kroymann, D., Mitchell Olds, T., “The glucosinolate–
myrosinase system in an ecological and evolutionary context,” Current Opinion in
Plant Biology, 8(3),pp. 264–27,2005.
111.DeVos, R. H., Blijleven, W. G., “The effect of processing conditions on
glucosinolates in cruciferous vegetables,” Zeitschrift für LebensmittelUntersuchung und Forschung, 187(6), pp. 525-529, 1988.
112.Bertelli, D., Plessi, M., Braghiroli, D., Monzani, A., “Separation by solid phase
extraction and quantification by reverse phase HPLC of sulforaphane in broccoli,”
Food Chemistry, 63(3), pp. 417–421, 1998.
113.Liang, H., Yuan, Q. P., Dong, H. R., Liu, Y. M., “Determination of sulforaphane in
broccoli and cabbage by high-performance liquid chromatography”, Journal of
Food Composition and Analysis., 19, pp. 473–476,2006.
114.Liang, H., Li, C., Yuan, Q., Vriesekoop F., “Separation and purification of
sulforaphane from broccoli seeds by solid phase extraction and preparative highperformance liquid chromatography,” J Agric Food Chem, 55(20), pp.8047-53,
2007.
115.Agrawal, S., Winnik, B., Buckley, B., and Mi. L., “Simultaneous determination of
sulforaphane and its major metabolites from biological matrices with liquid
chromatography-tandem mass spectroscopy,” J Chromatogr B, 840, pp. 99–107,
2006.
116.Nakagawa, K., Umeda, T., Higuchi, O., Tsuzuki, T., Suzuki, T., and Miyazawa, T.,
“Evaporative Light-Scattering Analysis of Sulforaphane in Broccoli Samples: 121
Quality of Broccoli Products Regarding Sulforaphane Contents,” J. Agric. Food
Chem., 54 (7), pp. 2479–2483, 2006.
117.Matusheski, N. V., Swarup, R., Juvik, J. A., Mithen, R., Bennett, M., and Jeffery,
E. H., “Epithiospecifier Protein from Broccoli (Brassica oleracea L. ssp. italica)
Inhibits Formation of the Anticancer Agent Sulforaphane,” J. Agric. Food Chem.,
54 (6), pp. 2069–2076, 2006.
118.Cuijuan, H. L., Yuan, Q., and Vriesekoop, F., “Application of High-Speed
Countercurrent Chromatography for the Isolation of Sulforaphane from Broccoli
Seed Meal,” J. Agric. Food Chem., 56 (17), pp. 7746–7749, 2008.
119.Rochfort, S., Caridi, D., Stinton, M., Trenerry, V.C., Jones, R., “The isolation and
purification of glucoraphanin from broccoli seeds by solid phase extraction and
preparative high performance liquid chromatography,” J Chromatogr A,1120(1-2),
pp.205-210, 2006.
120.Ugolini, L., DeNicola, G., Palmieri, S., “Use of reverse micelles for the
simultaneous extraction of oil, proteins, and glucosinolates from cruciferous
oilseeds,” J Agric Food Chem, 56, pp. 1595-1601, 2008.
121.You, Y., Wu Y., Mao, J., Zao, L., Shiwang, L., “Screening of Chinese Brassica
species for anticancer sulforaphane erucin,” African Journal Of Biotechnology,
7(2), pp. 147-152, 2008.
122.Tookey, H. L., Daxenbichler, M. E., Van Etten, C. H., Kwofhlick W. F., Williams,
P.H., “ Cabbage glucosinolates and its correspondence of patterns in seeds and
leafy heads,” J Amer Soc Hort Sci, 105, pp. 714-717,1980.
123.Staack, R., Kingston, S., Wallig, M. A., Jeffrey, P. H., “A comparison of individual
and collective effects of four glucosinolate breakdown products from brussels
sprouts on induction of detoxification enzymes.” Toxicol Appl Pharm., 149, pp. 1723, 1998.
124.Brown, K. K., Blaikie, F. H., Smith, A. J., Tyndall, A., Lue, H., Bernhagen, J.,
Winterbourn, C. C., and Hampton, M. B., “Direct modification of the
proinflammatory cytokine macrophage migration inhibitory factor by dietary
isothiocyanates,” J. Biol. Chem, 284, pp.32425–32433, 2009.
125.Heiss, E., Herhaus, C., Klimo, K., Bartsch, H., Gerhäuser, C., “Nuclear factor
kappa B is a molecular target for sulforaphane-mediated anti-inflammatory
mechanisms,” J Biol Chem, 276(34), pp.32008-32015, 2001.
126.Gamet-Payrastre, L., Li, P., Lumeau, S., Cassar, G. Dupont, M.A., Chevolleau, S.,
Gasc, N., Tulliez, J., Tercé, F., “Sulforaphane, a Naturally Occurring
122
lsothiocyanate, induces Cell Cycle Arrest and Apoptosis in HT29 Human Colon
Cancer Cells,” Cancer Research., 60, pp. 1426-1433, 2000.
127.Waltenberg, L. W., and Loub, W. D., “Inhibition of polycyclic aromatic
hydrocarbon induced neoplasia by naturally occuring indoles”, Cancer Research,
38, pp. 1410-1413, 1978.
128.Cover, C. M., Hsieh, S. J., Tran, S. H., Hallden, G., Kim, G. S., Bjeldanes, L. F. &
Firestone, G. L. “Indole-3-carbinol inhibits the expression of cyclin-dependent
kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells
independent of estrogen receptor signalling,” J. Biol. Chem. 273 pp. 3838–3847,
1998.
129.Hong, C., Kim, H. A., Firestone, G. L. & Bjeldanes, L. F., “3,3′- Dindolylmethane
(DIM) induces a G1 cell cycle arrest in human breast cancer cells that is
accompanied
by
Sp1-mediated
activation
p21WAF1/CIP1expression,
Carcinogenesis, 23, pp. 1297–1305, 2002.
130.Grana, X., Reddy E. P. “Cell cycle control in mammalian cells: role of cyclins,
cyclin dependent kinases (cdks) growth suppressor gene and cyclin-dependent
kinase inhibitors (cdki),” Oncogene, 11, pp.211-219, 1995.
131.Tang, L, Zhang, Y., “Dietary isothiocyanates inhibit the growth of human bladder
carcinoma cells,” J Nutr, 134, pp. 2004–2010, 2004.
132.Singh, S.V., Herman-Antosiewicz, A., Singh A.V., Lew, K. L., Sivastava S.K.,
Kamath, R., Brown, K.D., Zhang, L., and Baskaran, R., “ Sulforaphane induced
G2/M phase cell cycle arrest involves checkpoint kinase 2 mediated
phosphorylation of Cdc25C”, J of Biol Chem., 280, pp. 19911-19924, 2004.
133.Xu, C., Huang, M. T., Shen, G., Yuan, X., Lin, W., Khor, T. O., Conney, A. H., and
Kong, A. N. “ Inhibition of dimethylbenzanthracene induced skin tumorigenesis in
C57BL/6 mice by Sulforaphane is mediated by nuclear factor E2 related factor 2,”
Cancer Research., 66, pp 8293-8296.2006.
134.Grubbs, C. J., Steele, V. E., Casebolt, T., Juliana, M. M., Eto, L., Whitaker, L. M.,
Dragnev, K. H., Kelloff, G. J., and Lubet, R. L., “Chemoprevention of chemically
induced mammary carcinogenesis by Indole 3 Carbinol,” Anticancer Research,15,
pp. 709-716.1995.
135.Brandi, G., Schiavano, G. F., Marco, C. D., Zaffaroni, N., Palardi, M., Cervasi, B.,
Magnani, M., “Mechanisms of action and antiproliferative properties of Brassica
oleracea juice in human Breast cancer cell lines,” Journal of Nutrition, 135, pp.
1504-1509, 2005.
123
136.Bhatnagar, N.,Li, X., Chen, Y., Zhou, X., Garrett, S.H., Guo, B., “3,3′Diindolylmethane enhances the efficacy of butyrate in colon cancer prevention
through down-regulation of surviving,” Cancer Prev Res, 2, pp.581–589,2009.
137.Dashwood, R. H., “Indole-3 carbinol: Anticarcinogen or tumor promoter in brassica
vegetables?, “Chemico-Biological Interactions, 110, pp. 1-5, 1988.
138.Gasper, A.V., Traka, M., Bacon, J. R., Smith, J. A., Taylor, M. A., Hawkey, C.J.,
Barrett, D. A., Mithen, R. F., “Consuming Broccoli Does Not induce Genes
Associated with Xenobiotic Metabolism and Cell Cycle Control in Human Gastric
Mucosa,” The Journal of Nutrition.,137, pp.1718-1724, 2007.
139.Elliott, M. C., Stowe, B. B., “Indole compounds related to auxins and goitrogens of
woad (Isatis tinctoria), Plant physiol, 47, pp.366-372, 1971.
140.Zhang, Y., Tang, L., and Gonzalez, V., “Selected isothiocyanates rapidly induce
growth inhibition of cancer cells,” Mol Cancer Ther, 2, pp.1045-1052, 2003.
141.Fimognari, C., Niisse, M., Cesari, R.., Lori, R., Cantelli- Forti, G., Hrelia, P.
“Growth inhibition cell cycle arrest and apoptosis in human T cell leukemia by the
isothiocynate Sulforaphane, Carcinogenesis., 23, pp.581-586, 2002.
142.Denoyelle, C., Aibanese, P., Li, G., Jean, H., Vannier, P., Soria, J., Soria, C.,
“Molecular mechanism of the anticancer activity of cerivastatin an inhibitor of
HMG Co A reductase on aggressive human breast cancer cells,” Cellular
Signalling, 15, pp.327-338, 2003.
143.Firestone, G. L. and Bjeldanes, L.F., “Indole 3 carbinol and 3-3’ indolyl methane
signalling pathways control cell cycle Gene transcription in Human Breast Cancer
cells by regulating promoter-Sp1 Transcription factor interactions,” The Journal of
Nutrition,133, pp. 2448-2455, 2003.
144.Pan, M. H. Ghai, G., Ho, C. T., “Food bioactives, apoptosis, and cancer, Molecular
Nutrition & Food Research,” 52 (1), pp. 43–52, 2008.
145.Matsui, T. A., Sowa, Y., Yoshida, T., Horinaka, M., Murata, H., Wakada, M.,
Nakanishi, R., Sakabe, T., Kubo, T., Sakai, T, “Sulforaphane enhances TRAIL
induced apoptosis through the induction of DR5 expression in human
Osteosarcoma cells,” Carcinogenesis, 27, pp.1768-1777, 2006.
146.Jin, C.Y., Moon, D.O., Moon, J. D. L., Lee, J. D., Heo, M. S., Choi, Y.H., Lee, C.
M., Park, Y. M., Kim, G. Y.” Sulforaphane sensitizes tumor necrosis factor related
apoptosis induced ligand mediated apoptosis through downregulation of ERK and
AKT in Lung Adenocarcinoma A549 cells,” Carcinogenesis, 28, pp.1058-1066,
2007.
124
147.Pappa, G., Lichtenberg, M., Lori, R., Barillari, J., Bartsch, H., Gerhauser, C..
“Comparision of growth inhibition profiles and mechanisms of apoptosis induction
in human colon cancer cell lines by isothiocyanates and indoles from
Brassicaceae,” Mutation Research, 599, pp. 76-87, 2006.
148.Pledgie-Tracy, A., Sobolewski, M. D., Davidson, N. E., “Sulforaphane induces cell
type specific apoptosis in human breast cancer cell lines,” Molecular cancer
therapeutics, 6, pp.1013-1021, 2007.
149.Jakubikova, J., Sedlak, J., Bacon, J., Goldson, A., Bao, Y., “ Effects of MEK1 and
PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M
arrest and cell death in Caco-2 cells,” Int J Oncol,27(5), pp.1449–58,2005.
150.Tang, Li., Zhang, Y., Jobson, H.F., Li, J., Stephenson, K.K., Wade, K.L., and
Fahey, J.W., “Potent activation of mitochondria-mediated apoptosis and arrest in S
and M phases of cancer cells by a broccoli sprout extract,” Mol Cancer Ther, 5, pp.
935-944,2006.
151.Costello, J. F., Plass, C., Arap, W., Chapman, V.M., Held, W.A, Berger, M.S, Su
Huang, H.J., Cavenee, W.K., “Cyclin-dependent kinase 6 (CDK6) amplification in
human gliomas identified using two-dimensional separation of genomic DNA,”
Cancer Res, 57, pp.1250-1254,1997.
152.Esteller, M., “Epigenetic gene silencing in cancer: the DNA hypermethylome,”
Hum Mol Genet, 16, pp. 50–59, 2007.
153.Zhivotovsky, B., Samali, A., Grahm, A. and Orrenius, S, “Caspases: their
intracellular localization and translocation during apoptosis,” Cell Death Differ., 6,
pp.644–651, 1999.
154.Wolter, K. G., Hsu, Y. T., Smith, C. L., Nechushtan, A., Ki, X. G., Youle, R. J.
“Movement of bax from the cytosol to mitochondria during apoptosis,” J. Cell.
Biol., 139, pp.1281-1292, 1997.
155.Huang, C., Ma, W. Y., Li, J., Hecht, S. S., and Dong, Z., “Essential role of p53 in
phenethyl isothiocyanate induced apoptosis,” Cancer Research, 58, pp. 4102-4106.
1998.
156.Granville, D. J., Shaw, J. R., Leong, S., Carthy, C.M., Margaron, P., Hunt, D.W.,
Manus, B.M., “Release of cytochrome c, Bax migration, Bid cleavage, and
activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis,” Am. J.
Pathol, 155, pp.1021–1025, 1991.
157.Yu, R., Mandhya, S., Harvey, K. J., Ucker, D.S., Kong, C., “Chemopreventive
isothiocyanates induces apoptosis and caspase 3 like protease activity,” Cancer
research, 58, pp. 402-408, 1998.
125
158.Jackson, S. J. T., Singletary, K. W., Venema, R. C., “Sulforaphane suppresses
angiogenesis and disrupts endothelial mitotic progression and microtubule
polymerization,” Vascular Pharmacology, 46(2), pp. 77–84, 2007.
159.Smith, T. K., Lund, E. K., and Johnson, I.T., “Inhibition of dimethylhydrazineinduced aberrant crypt foci and induction of apoptosis in rat colon following oral
administration of the glucosinolate sinigrin,” Carcinogenesis, 19 (2), pp.267-273,
1998.
160.Chen, I., Doughal, M. C., Wang, F.A., & Safe, S., “Aryl hydrocarbon receptormediated antiestrogenic and antitumorigenic activity of diindolylmethane,”
Carcinogenesis, 19, pp.1631–1639, 1998.
161.Leong, H., Firestone G. L., and Bjeldanes L. F., “ Cytostatic effects of 3,3′diindolylmethane in human endometrial cancer cells result from an estrogen
receptor-mediated increase in transforming growth factor-α expression,”
Carcinogenesis, 22 (11), pp.1809-1817, 2001.
162.Chen, D. Z., Qi, M., Auborn, K. J. and Carter, T. H. “Indole-3-carbinol and
diindolylmethane induce apoptosis of human cervical cancer cells and in murine
HPV16-transgenic preneoplastic cervical epithelium,” J Nutr, 131, pp.3294–3302,
2001.
163.Hoeppner, D. J., Hengartner, M. O., Schnabel, R., “Engulfment genes cooperate
with ced-3 to promote cell death in Caenorhabditis elegans,” Nature, 412, pp. 202–
206, 2001.
164.Bedner, E., Xun, Li., Kunicki, J., Darzynkiewicz, Z., “Translocation of Bax to
mitochondria during apoptosis measured by laser scanning cytometry,” Cytometry,
41(2), pp. 83–88, 2000.
165.Jia, L., Srinivasula, S. M., Liu, F.T., Newland, A. C., Alnemri, F. T., Alnemri E.S.,
Kelsey, S. M., “Apaf-1 protein deficiency confers resistance to cytochrome cdependent apoptosis in human leukemic cells,” Blood, 98, pp.414–421,2001.
166.Chinni, S. R., Li, Y., Upadhyay, S., Koppolu, K. P., and Sarkar, F. H., “Indole-3carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in
prostate cancer cells,” Oncogene, 20(23), pp. 2927-2936, 2001.
167.Chen, Y. R, Meyer, C. F, Tan T. H., “Persistent activation of c-Jun N-terminal
kinase 1 (JNK1) in γ radiation-induced apoptosis,” J Biol Chem, 271, pp.631–634,
1996.
168.Favreau, L. V., Pickett, C. B., “The Rat Quinone Reductase Antioxidant Response
Element Identification of the nucleotide sequence required for basal and inducible
126
activity and detection of antioxidant response element-binding proteins in hepatoma
and non-hepatoma cell lines,” J. Biol. Chem. 270, pp.24468–24474,1995.
169.Krul, C., Humblot, C., Philippe, C., Vermeulen, M., M. V., Havenaar, R.,and
Rabot, S., “Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic
microflora in a dynamic in vitro large-intestinal model,” Carcinogenesis, 23 (6),
pp.1009-1016, 2002.
170.Fimognari, C., Nusse,M., Lenzi, M.,. Sciuscio, D., Cantelli-Forti,G., and Hrelia,
P., “Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts
characterized by p53 mutations,” Mutation Research, 601(. 1-2), pp. 92–101, 2006.
171.Kim. S., Shin, H. J., Kim, S. Y., Kim, J. H., Lee, Y., Skim, D. H., Lee, Y.O.,
“Genistein enhances expression of genes involved in fatty acid catabolism through
activation of PPACr,” Molecular and cellular endocrinology, 220(1-2), pp.51-58,
2004.
172.Borek, C., “Antioxidants and cancer science and medicine, the baby boomers
guide,” The New Canaan connecticus, Keats Publishing, 4, pp.51-61, 1991.
173.Xianquan, S., Shi, J., Kakuda, Y., Yueming, J., “Stability of lycopene during food
processing storage,” J Medicinal food 8(4), pp. 413-422, 2005.
174.Chen, X., and Ahn, D.U., “Antioxidant activities of six natural phenolics against
lipid oxidation induced by Fe 2+ ultraviolet light,” Journal of American chemical oil
society 75(12), pp.1717-1721, 1998.
175.Donaldson, M. S., “Nutrition and cancer: A review of the evidence for an anticancer diet,” Nutrition Journal, 3(19), 2004.
176.Tsuda, T., Watanabe, M., Ohshima, K., Norinobu, S., Choi, W., Kawakishi, S., and
Osawa, T., “Antioxidative activity of the anthocyanin pigments cyanidin 3-O-βDglucoside and cyanidin,” J. Agric. Food Chem., 42, pp.2407-2410, 1994.
177.Wills, R. B. H., Wong, A.W.K., Scriven, F.M., and Greenfield, H., “Nutrient
composition of Chinese vegetables.” J. Agric. Food Chem., 32(1), pp.413-416,
1984.
178.Tee, E.S., Noor, M. I., Azudin, M. N., Idris, K., “ Nutrient composition of
malaysian foods,” Institute for Medical Research, Kuala Lumpur, Malaysia, 1997.
179.Colditz, G. A. Branch, L. G., and Lipnic, R. J., “Increased green and yellow
vegetable intake and lowered cancer deaths in an elderly population,” American
Journal of Clinical Nutrition, 41, pp.32-36, 1985.
127
180.Song, K., Lee, W. J., Koh, J. M., Kim, H.S., Youn, J.Y., Park, H.S., Koh, E.H.,
Kim, M. S., Youn, J. H., Lee, K.U., Park, J. Y., “ α-Lipoic acid prevents diabetes
mellitus in diabetes-prone obese rats,” Biochem Biophys Res Comm, 326, pp.197–
202, 2004.
181.Kawamoto, Y., Nakamura, Y., Naito, Y., Torii, Y., Kumagai, T., Osawa, T.,
Ohigashi, H., Satoh, K., Imagawa, M., Uchida, K., “Cyclopentenone prostaglandins
as potential inducers of phase II detoxification enzymes. 15-deoxy-δ prostaglandin
J2-induced expression of glutathione S-transferases,” The Journal of Biological
Chemistry, 275(15), pp. 11291–11299, 2000.
182.Xu, K. and Thornalley, P. J., “Involvement of GSH metabolism in the cytotoxicity
of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells
in vitro,” Biochemical Pharmacology, 61, pp.165 - 177 (0006-2952), 2001.
183.Rowan, B. G., Garrison, N., Weigel, N. L., and Malley, B.W., “8-Bromo-cyclic
AMP induces phosphorylation of two sites in SRC-1 that facilitate ligandindependent activation of the chicken progesterone receptor and are critical for
functional cooperation between SRC-1 and CREB binding protein,” Mol. Cell.
Biol., 20, pp. 8720–8730, 2000.
184.Bittencourt, P. H., Miyasaka, C. K., Curi, R., Williams, J. F., “Effects of the
antiproliferative cyclopentenone prostaglandinal on Glutathione metabolism in
Human cancer cells in Culture,” Biochemistry and Molecular Biology International,
45(6), pp.1255-1264, 1998.
185.Shan, Y., Sun, C ., Zhao, X., Wu, K ., Bao, C. A., “Effect of sulforaphane on cell
growth, G(0)/G(1) phase cell progression and apoptosis in human bladder T24
cells,” Int J Oncology., 29, pp. 883-888, 2006.
186.Barcelo, S., Gardiner, S.M., Gescher, A., Chipman, J. K., “CYP2E1 mediated
mechanism of antigenotoxicity of broccoli constituent sulforaphane,”
Carcinogenesis, 17(2), pp.277-282, 1996.
187.Kore, A. M., Spencer, G. F., Wallig, M. A., “ Purification of ω methyl sulfinyl
alkyl glucosinolate hydrolysis products 1-isothiocyanato 4 methyl sulfinyl propane,
1-isothiocyanato 4 methyl sulfinyl butane,4, methylsulfinylbutane nitrile,5
methylsulfinylpentane nitrile, from broocoli and lesquerella fendleri,” Journal of
Agricultural and Food chemistry, 41, pp.81-95,1993.
188.Liu, L. L., Gong, L. K., Qi, X. M., Cai, Y., Wang, H., Wu, X. F., Xiao, Y., Ren, J.,
“Altered expression of cytochrome P450 and possible correlation with
preneoplastic changes in early stage of rat hepatocarcinogenesis,” Acta Pharmacol
Sin, 26, pp.737–744, 2005.
128
189.Kim, D. J., Lee, K. K., Han, B. S., Ahn, B., Bae, J. H., Jang, J. J., “Biphasic
modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic
glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley
rats,” J Cancer Res 85, pp. 578–583,1994.
.
190.Elson, C.E., Yu,S.G., “The chemoprevention of cancer mevanolate derived
constituents of fruits and vegetables,” J Nutr.,124, pp. 607-614,1994.
191.Singh, S. V., Herman-Antosiewicz, A., Singh, A.V., Lew, K. L., Srivastava S. K,
Kamath, R, Brown, K.D., Zhang, L., Baskaran, R., “Sulforaphane-induced G2/M
Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation
of Cell Division Cycle 25C,” J. Biol. Chem, 279, pp.25813–25822, 2004.
192.Quattrochi, L. C., Vu, T., and Tukey, R. H., “The human CYP1A2 gene and
induction by 3-methylcholanthrene. A region of DNA that supports Ah-receptor
binding and promoter-specific induction,” J Biol Chem, 269, pp. 6949–6954, 1994.
193.Yu, R., Jiao, J. J., Duh, J. L, Gudehithlu, K., Tan, T. H., Kong, A.N., “Activation of
mitogen-activated protein kinases by green tea polyphenols: potential signalling
pathways in the regulation of antioxidant-responsive element-mediated phase II
enzyme gene expression,” Carcinogenesis.,18(2), pp.451-456,1997.
194.Stoewsand, G. S., “Bioactive organosulfur phytochemicals in Brassica oleracea
vegetables--a review,” Food Chem Toxicol, 33(6), pp.537-543, 1995.
195.Iwu, M. M., Unaeze, N. C., Okunji, C. O., Corley, D. G., Sanson, D. R., Tempesta,
M. S., “Antibacterial aromatic isothiocyanates from the essential oil of Hippocratea
welwitschii roots,” Int J Pharmacogn, 29, pp.154–158, 1991.
196.Korber, D. R., Choy, D., Wolfaardt, G. M., Ingham, C.,and Caldwell, D. E.,
“Substratum topography influences susceptibility of Salmonella enteritidis
biofilms to trisodium phosphate,” Appl Environ Microbio, 63(9), pp. 3352–3358,
1997.
197.Hong, E., and Kim, G. H., “Anticancer and Antimicrobial Activities of ßPhenylethyl Isothiocyanate in Brassica rapa L,” Food Sci. Technol. Res., 14 (4),
pp.377 – 382, 2008.
198.Sahoo, G. C., Rani, M., Dikhit, M. R., Ansari, W. A., Das, P, “Structural
Modelling, Evolution and Ligand Interaction of KMP11 Protein of Different
Leishmania Strains,” J Comput Sci Syst Biol, 2, pp. 147-151, 2009.
199.Bhoi, D., (2012), “Dietary bioactive compounds as histone deacetylase inhibitor for
cancer prevention,” M.Sc Thesis, National Institute of Technology, Rourkela.
200.Stahler, C., “How many adults are vegetarian?,” Veg J, 25, pp.14–15, 2006.
129
201.Fox, N., Ward, K., “Health, ethics and environment: a qualitative study of
vegetarian motivations,” Appetite, 50, pp.422–429, 2008.
202.Spencer, G. F., Daxenbichler, E.,” Gas chromatography-mass spectrometry of
nitriles, isothiocyanates and oxazolidinethiones derived from cruciferous
glucosinolates,” Journal of the Science of Food Agriculture, 31, pp. 359–367, 1980.
203.Chiang, W. C., Pusateri, D. J., Leitz, R. E., “Gas chromatography/mass
spectrometry method for the determination of sulforaphane and sulforaphane nitrile
in broccoli,” Journal of Agricultural and Food Chemistry, 46, pp.1018–1021, 1998.
204.Matusheski, N. V., Walling, M. A., Juvic, J. A., Klein, B. P., Kushad, M. M.,
Jeffery, E. H., “Preparative HPLC method for the purification of sulforaphane and
sulforaphane nitrile from Brassica oleraceae,” J. Agr. Food Chem, 49, pp.1867–
1872, 2001.
205.Visht, S., Chaturvedi, S., “Isolation of Natural Products,” Current Pharma
Research, 2(3), pp.584-599, 2012.
206.Kraemer, H., “History of maceration and Percolation,” American Journal of
Pharmacy, 82, pp.32-42, 1910.
207.Rawa-Adkonis, M., Wolska, L., Namiesnik, J., “Modern techniques of extraction of
organic from environmental matrices,” Critic. Rev. Anal. Chem, 33, 199, 2003.
208.Camel, V., “Solid phase extraction of trace elements,” Spectrochimica Acta B, 58,
1177, 2003.
209.Zwir-Ferenc, A., Biziuk, M., “Solid Phase Extraction Technique – Trends,
Opportunities and Applications,” Polish J. of Environ. Stud, 15(5), pp. 677-690,
2006.
210.Ferrer, I., Barcelo, D., “Validation of new solid-phase extraction materials for the
selective enrichment of organic contaminants from environmental samples,” Trend
Anal Chem, 3, 180, 1999.
211.Muller, A., Bjorklund, E., Vonholst, C.H., “ On-line of pressurized liquid extracts
for the determination of polychlorinated biphenyls in feeding stuffs and food
matrices using gas chromatography-mass spectrometry,” J. Chromatography A,
925, 197, 2001.
212.Farid, A. E., Trends Anal Chem, 20, 649, 2001.
213.Font, G., Manes, J., Molto, J. C., Pico, Y., “Solid-phase extraction in multi-residue
pesticide analysis of water,” J. Chromatogr A, 642, 135, 1993.
130
214.Wells, D. A., “Solid-phase extraction of acidic herbicides,” Liq Chr-Gas Ch, 17,
600, 1999.
215.Tyszkiewicz, H., Biziuk, M., Hupka, J., Zaleska, A., “Determination of
organochlorine pesticides in water suspension by means of liquid-liquid extraction,
solid phase extraction, solid phase microextraction and direct aqueous injection,”
Chem. Inz. Ekol, 8, pp.935, 2001.
216.Rochfort, S., Caridi, D., Stinton, M., Trenerry, C. V., Jones, R., “The isolation and
purification of glucoraphanin from broccoli seeds by solid phase extraction and
preparative high performance liquid chromatography,” Journal of Chromatography
A, 1120, pp.205–210, 2006.
217.Sporring, S., Bjorklund, E., “Selective pressurized liquid extraction of
polychlorinated biphenyls from fat-containing food and feed samples Influence of
cell dimensions, solvent type, temperature and flush volume,” J. Chromatogr A, pp.
1040, 155, 2004.
218.Ilic, N., Normanly, J., Cohen, J. D., “Quantification of free plus conjugated
Indoleacetic acid in Arabidopsis Requires correction for the non enzymatic
conversion of Indole nitriles,” Plant physiology, 111, pp.781-788, 1996.
219.Ye, H., Hao, L., Qi-peng, Y., “Qualitative identification of the sulforaphane of
cruciferae by thin layer chromatography,” 34 (2), pp. 33-36, 2006.
220.Zhang, Y., Talalay, P., Cho, C. G., and Posner, G. H., “A major inducer of
anticarcinogenic protective enzymes from broccoli: isolation and elucidation of
structure,” Proc Natl Acad Sci USA, 89 (6), pp.2399–2403, 1992.
221.Lopes, T. J., Gonçalves, O. H., Barros, R. B., Capelli, F.C.R., Machado, R.A.F.,
Quadri, M.G.N., Quadri, M.B. “Adsorption of Natural Dyes on Clay Fixed on
Polymers,” Brazilian archives of Biology and Technology, 48-Special, pp.275 –
280,2005.
222.Stoner, G. D., and Morse, M. A., “Isothiocyanates and plants polyphenols as
inhibitors of lung and esophageal cancer,” Cancer Lett., 114(17), pp.113-119, 1997.
223.Chung, F. L., Kelloff,, G., Steele, V., Pittman, B., Zang, E., Jiao, D., Rigotty, J.,
Choi, C.I. and Rivenson, A. “Chemopreventive efficacy of arylalkyl
isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats,”
Cancer Res., 56, pp.772-778, 1996.
131
224.Fahey, J. W., Zhang, Y., and Talalay, P., “Broccoli sprouts: An exceptionally rich
source of inducers of enzymes that protect against chemical carcinogens,” Proc Natl
Acad Sci USA., 94, pp.10367-10372, 1997.
225.Hennion, M. C., “Solid-phase extraction: method development, sorbents, and
coupling with liquid chromatography,” J Chromatogr. A, 856 (3), 1999.
226.Sabik, H., Jeannot, R., Rondeau, B., “Multiresidue methods using solid phase
extraction techniques for monitoring priority pesticides, including triazines and
degradation products, in ground water,” J. Chromatogr A, 885, 217, 2000.
227.Pichon, V., “Solid-phase extraction for multiresidue analysis of organic
contaminants in water,” J. Chromatogr A, 885, 195, 2000.
228.Brydoy, M., Fosså, S.D., Dahl, O., Bjoro, T., “Gonadal dysfunction and fertility
problems in cancer survivors,” Acta Oncol, 46 (4), pp. 480–489, 2007.
229.Chabner, B., Longo, D. L.,(2005), Cancer Chemotherapy and Biotherapy:
Principles and Practice (4th ed.), Lippincott Willians & Wilkins, Philadelphia.
230.Okigbo, R. N., Anuagasi, C. L., and Amadi, J. E., “Advances in selected medicinal
and aromatic plants indigenous to Africa,” Journal of Medicinal Plants Research,
3(2), pp. 86-95, 2009.
231.Liu, R.H., “Health benefits of fruit and vegetables are from additive and synergistic
combinations of phytochemicals,” Am J Clin Nutr, 78(3), pp. 517-520, 2003.
232.Edmondson, J. M., Armstrong, L. S., Martinez, A.O., “A rapid and simple MTT
based spectrophotometric assay for determining drug sensitivity in monolayer
cultures”, Journal of Tissue Culture Methods, 2, pp. 15-17, 1988.
233.Nunez, R., “DNA measurement and Cell cycle analysis by Flow cytometry,” Curr
Issues in Mol Biology, 3(3), pp.67-70, 2001.
234.Darzynkiewicz, Z., Crissman. H., and Jacobberger, J. W., “Cytometry of the Cell
Cycle: Cycling Through History,” Cytometry, 58, pp.21–32, 2004.
235.George, S., Bhalerao, S. V., Lidstone, E. A., Ahmad, I. S., Abbasi, A.,
Cunningham, B. T and Watkin, K. L., “Cytotoxicity screening of Bangladeshi
medicinal plant extracts on pancreatic cancer cells, BMC Complementary and
Alternative Medicine, 10,52,2010.
236.Pieters, R, Huismans, D. R., Leyva, A., Veerman, A. J. P., “Adaptation of the rapid
automated tetrazolium dye based (MTT) assay for chemosensitivity testing in
childhood leukemia,” Cancer letters , 41(3), pp. 323-332,1988.
132
237.Chan, L.L., Gosangari, S.L., Watkin, K.L., Cunningham, B.T., “ Label-free
imaging of cancer cells using photonic crystal biosensors and application to
cytotoxicity screening of a natural compound library,” Sensors & Actuators: B
Chemical, 132(2), pp.418-425, 2008.
238.Yina, X., Zhoua, J., Jieb, C., Xing, C.,D., Zhanga, Y., “Anticancer activity and
mechanism of Scutellaria barbata extract on human lung cancer cell line A549,”
Life sciences,75, pp. 2233 -2244,2004.
239.Tyers, M., Futcher, B., “Far1 and Fus3 link the mating pheromone signal
transduction pathway to three G1-phase Cdc28 kinase complexes,” Mol Cell Biol,
13, pp.5659–5669, 1993.
240.Sagar, S., Yance, D., and Wong, R.K., “Natural health products that inhibit
angiogenesis: a potential source for investigational new agents to treat cancer,”
Curr Oncol., 13(1), pp. 14–26, 2006.
241.Iwu, M. M., Duncan, A. R., Okunji, C. O., (1999). “New Antimicrobials of plant
origin, Perspectives in new crops and new uses,” In Janick, J.(ed), ASHS Press,
Alexandria, V.A. pp. 457-462.
242.Urquiaga, I., Leighton, F., “Plant polyphenols, antioxidants and oxidative stress,”
Biol. Res, 33, pp. 159-165, 2000.
243.Okwu, D.E., “Phytochemicals and vitamin content of indigenous spices of South
Eastern Nigeria,” J. Sustain. Agric. Environ, 6, pp. 30-34, 2004.
244.Chatterji, U., Riby, J.E., Taniguchi, T., Bjeldanes, E.L., Bjeldanes, L.F., and
Firestone, G.L., “Indole-3-carbinol stimulates transcription of the interferon gamma
receptor 1 gene and augments interferon responsiveness in human breast cancer
cells,” Carcinogenesis, 25, pp. 1119–1128, 2004.
245.Azarenko, O., Okouneva, T., Singletary, K, W., Jordan, M. A., and Wilson, L.,”
Suppression of microtubule dynamic instability and turnover in MCF7 breast
cancer cells by sulforaphane,” Carcinogenesis,29 (12), pp.2360-2368, 2008.
246.Gamet-Payrastre, L., Lumeau, S., Gasc, N., Cassar, G., Rollin, P. & Tulliez, J.
“Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on
human colon cancer cells in vitro,” Anticancer Drugs, 9, pp.141-148,1998.
247.Kim, M. J., Kim, S. H., and Lim, S. J., “Comparison of the Apoptosis-inducing
Capability of Sulforaphane Analogues in Human Colon Cancer Cells,” Anticancer
Research, 30(9), pp. 3611-3619, 2010.
248.Podsedek, A., “Natural antioxidants and antioxidant capacity of Brassica
vegetables,A review,” Lwt-Food Sci. Technol, 40, pp. 1-11,2007.
133
249.Jahangir, M., Kim, H.K., Choi, Y.H., Verpoorte, R., “Health-Affecting Compounds
in Brassicaceae,” Comp. Rev. Food Sci. Food Saf, 8, pp. 31-43, 2009.
250.Melchini, A., and Traka, M. H., “Biological Profile of Erucin: A New Promising
Anticancer Agent from Cruciferous Vegetables,” Toxins (Basel), 2(4), pp. 593–
612, 2010.
251.Nakamura, Y., Miyoshi, N., “Cell death induction by isothiocyanates and their
underlying molecular mechanisms,” Biofactors, 26(2), pp.123-134, 2006.
252.Conaway, C.C., Yang, Y.M., Chung, F.L., “Isothiocyanates as cancer
chemopreventive agents: their biological activities and metabolism in rodents and
humans,” Curr Drug Metab, 3(3), pp. 233-255, 2002.
253.Sherr, C. J., “Cancer cell cycles,” Science 274, pp.1672–1677, 1996.
254.Morgan, D. O., “Principles of CDK regulation,” Nature, 374, pp.131–134, 1995.
255.Jenna, S., Clarke, D. J., Mackay, C. L., Hupp, T., Sadler, P. J.,and . LangridgeSmith, R.R.P., “Redox regulation of tumour suppressor protein p53: identification
of the sites of hydrogen peroxide oxidation and glutathionylation,” Chem. Sci., 4,
pp. 1257-1269, 2013.
256.Hamel, P.A., Hanley-Hyde, J., “G1 cyclins and control of the cell division cycle in
normal and transformed cells,” Cancer Invest, 15(2), pp.143-52, 1997.
257.Bernstein, C., Bernstein, H., (1991), Aging, Sex, and DNA Repair, Academic Press,
San Diego, CA.
258.Ames, B. N., Gold, L. S., “Endogenous mutagens and the causes of aging and
cancer,” Mutat Res, 250, pp.3-16, 1991.
259.Holmes, G. E., Bernstein, C., Bernstein, H., “Oxidative and other DNA damages as
the basis of aging: a review,” Mutat Res, 275, pp. 305-315, 1992.
.
260.Cheung, K. L., and Kong, A. N., “Molecular Targets of Dietary Phenethyl
Isothiocyanate and Sulforaphane for Cancer Chemoprevention,” AAPS J, 12(1), pp.
87–97, 2010.
261.Gartel, A. L., Radhakrishnan, S. K.,“Lost in transcription: p21 repression,
mechanisms, and consequences,” Cancer Res, 65(10), pp.3980–3985,2005.
262.Seghezzi, G., Patel, S., Ren, C.J., Gualandris,A., Pintucci, G., Robbins, E.S.,
Shapiro, R.L., Galloway, A.C., Rifkin, D.B., Mignatti, P., “ Fibroblast growth
factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in
134
the endothelial cells of forming capillaries: an autocrine mechanism contributing to
angiogenesis,” The Journal of Cell Biology,141, pp.1659-1673,1998.
263.Cigars: Health Effects and Trends. Smoking and Tobacco Control, (1998),
Bethesda (MD): U.S. Department of Health and Human Services, National
Institutes of Health, National Cancer Institute, 9, pp.127-130.
264.Bertram, J. S., “The molecular biology of cancer,” Molecular Aspects of Medicine,
21, pp.167-223, 2001.
265.Lawley. P. D., “DNA as a targeting agent of alkylating carcinogens.” Br.Med. Bull,
36, pp. 19-34, 1980.
266.Maritsi, D., Stagikas, D., Charalabopoulos, K., and Batistatou, A., “ What's new in
p53,” Hippokratia,10(3), pp.116–119, 2006.
267.Basu, A., Haldar, S., “The relationship between Bcl-2, Bax and p53 : consequences
for cell cycle progression and cell death,” Molecular Human Reproduction, 4(12),
pp.1099-1109,1998.
268.Sambrook, J., Russel, D. W., (2001), Molecular Cloning: A Laboratory Manual 3rd
Ed, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
269.Smisek, D. L., Hoagland, D. A., "Agarose gel electrophoresis of high molecular
weight, synthetic polyelectrolytes", Macromolecules, 22(5), pp. 2270, 1989.
270.Holden, M. J., Wang, L., (2008). "Quantitative Real-Time PCR: Fluorescent Probe
Options and Issues" Standardization and Quality Assurance in Fluorescence
Measurements II. Springer Series on Fluorescence, 6, pp. 489.
271.Wong, M. L., and Medrano, J. F., “Real-time PCR for mRNA quantitation,”
BioTechniques, 39, pp. 75-85, 2005.
272.Spanakis, E., “Problems related to the interpretation of autoradiographic data on
gene expression using common constitutive transcripts as controls,” Nucleic Acids
Res, 21, pp. 3809-3819, 1993.
273.Pfaffl M.W., Meyer, H. H. D., and Sauerwein, H., “Quantification of the insulin
like growth factor-1 mRNA: development and validation of an internally
standardised competitive reverse transcription-polymerase chain reaction,” Exp.
Clin. Endocrinol, Diabetes, 106, pp. 502–512, 1998.
274.Gibson, U. E., Heid, C. A. and Williams, P. M. “A novel method for real time
quantitative RT–PCR,” Genome Res., 6, pp.995–1001, 1996.
135
275.Mannhalter, C., Koizar, D. and Mitterbauer, G. “Evaluation of RNA isolation
methods and reference genes for RT–PCR analyses of rare target RNA,” Clin.
Chem. Lab. Med., 38, pp.171–177, 2000.
276.Cheng W. L., Lin T. Y, Tseng Y. H, Chu F.H, Chueh, P. J, Kuo, Y.H., Wang, S.Y.,
“Inhibitory Effect of Human Breast Cancer Cell Proliferation via p21-Mediated
G(1) Cell Cycle Arrest by Araliadiol Isolated from Aralia cordata Thunb,” Planta
Medica, 77, pp.164–168,2011.
277.Lam, M., Carmichael, A. R., Griffiths, H. R., “An Aqueous Extract of Fagonia
cretica Induces DNA Damage, Cell Cycle Arrest and Apoptosis in Breast Cancer
Cells via FOXO3a and p53 Expression,” PLoS ONE, 7(6), e40152, 2012.
278.Guo, Y., Srinivasa, S. M., Srinivasula Druilhe, A., Fernandes-Alnemri, T., and
Alnemri, E. S., “Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins
from Mitochondria,” Journal of Biological Chemistry, 277, pp.13430-13437, 2002.
279.Dumont, P. J., Leu, I. J., DellaPietra, C. A., George, D. L., & Murphy, M., “The
codon 72 polymorphic variants of p53 have markedly different apoptotic potential,”
Nature Genetics, 33, pp.357 – 365, 2003.
280.Chomczynski, P., and Sacchi, N., “Single-step method of RNA isolation by acid
guanidium thiocyanate-phenol-chloroform extraction,” Analytical Biochemistry,
162(1), pp. 156-159, 1987.
281.Lewinsohn, E., Steele, C. L., and Croteau, R., “Simple isolation of functional RNA
from woody stems of gymnosperms,” Plant Molecular Biology Reporter, 12(1),
pp.20-25, 1994.
282.Steinberg, L.S., and Regan, J. M., “mcrA-Targeted Real-Time Quantitative PCR
Method to Examine methanogen communities,” Appl Environ Microbiol, 75(13),
pp.4435–4442, 2009.
283.Lueders, T., and Friedrich, M.W., “ Evaluation of PCR amplification bias by
terminal restriction fragment length polymorphism analysis of small-subunit rRNA
and mcrA genes by using defined template mixtures of methanogenic pure cultures
and soil DNA extracts,” Appl. Environ. Microbiol, 69, pp.320-326, 2003.
284.Caccamo, A. E., Scaltriti, M., Caporali, A., D'Arca, D., Scorcioni, F., Candiano, G.,
Mangiola, M., Bettuzzi, S., “Nuclear translocation of a clusterin isoform is
associated with induction of anoikis in SV40-immortalized human prostate
epithelial cells,” Ann N Y Acad Sci.,1010, pp.514-519, 2003.
285.Tichopad, A., Dilger, M., Schwarz, G., Pfaffl, M.W., “Standardised determination
of real-time PCR efficiency from a single reaction setup,” Nucl Acids Res, 31(20),
e122, 2003.
136
286.Reed, J. C., “Dysregulation of Apoptosis in Cancer,” J Clin Oncol., 17(9), pp.
2941-2963, 1999.
287.Yuan, J., “Transducing signals of life and death,” Curr Opin Cell Biol, 9, pp.247251, 1997.
288.Mohan, S., Bustamam, A., Abdelwahab, S. I., Al-Zubairi, A. S., Aspollah, M.,
Abdullah, R., Elhassan, M. M., Ibrahim, M. Y., Syam, S., “Typhonium
flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP
cleavage and cytochrome c release: Its activation coupled with G0/G1 phase cell
cycle arrest,” Journal of Ethnopharmacology,131(3), pp.592-600, 2010.
289.Hay, S., and Kannourakis, G., “A time to kill: viral manipulation of the cell death
program,” J Gen Virol, 83(7), pp.1547–1564, 2002.
290.Wallace-Brodeur, R. R., and Lowe, S. W., “Clinical implications of p53
mutations,” Cell Mol. Life Sci., 55, pp. 64–75, 1999.
291.Morrin, M., Kelly, M., Barrett, N., Delaney, P., “Mutations of K ras and p53 genes
in colorectal cancer and their prognostic significance,” Gut, 35, pp.1127–1131,
1994.
292.Vogelstein, B., Lane, D, Levine, A.J., “Surfing the p53 network,” Nature, 408,
pp.307–310, 2000.
293.Maxwell, S. A., Capp, D., Acosta, S. A., “Telomerase activity in immortalized
endothelial cells undergoing p53-mediated apoptosis,” Biochem. Biophys. Res.
Commun., 241, pp. 642-645, 1997.
294.Bouzourene, H., Gervaz, P., Cerottini, J. P., Benhattar, J., Chaubert, P., Saraga, E.,
Pampallona, S., Bosman, F, T., and Givel, J. C., “p53 and Ki-ras as prognostic
factors for Dukes' stage B colorectal cancer,” Eur J Cancer, 36,
pp.1008–
1015,2000.
295.Morrin, M., Kelly, M., Barrett, N., Delaney, P., “Mutations of Ki-ras and p53 genes
in colorectal cancer and their prognostic significance,” Gut, 35, pp.1127–1131,
1994.
296.Vander Heiden, M. G., and Thompson, C. B. “Bcl-2 proteins: regulators of
apoptosis or of mitochondria l homeostasis?,” Nat. Cell Biol, 1, pp.209– 216, 1999.
297.Taylor, R. C., Cullen, S. P., Martin, S. J., “Apoptosis: controlled demolition at the
cellular level,” Nat Rev Mol Cell, 9, pp.231–241, 2008.
137
298.Williams, G. T., Smith, C. A., “Molecular regulation of apoptosis: Genetic controls
on cell death,” Cell, 74, pp.777-779, 1993.
299.Marzo, I., Naval, J., “Bcl-2 family members as molecular targets in cancer
therapy,” Biochemical pharmacology, 76, pp.939-946, 2008.
300.Bernard, P. S., and Wittwer, C. T., “Real-Time PCR Technology for Cancer
Diagnostics,” Clinical Chemistry, 48 (8), pp. 1178-1185, 2002.
301.Lianidou, E.S., Markou, A., “Circulating tumor cells as emerging tumor biomarkers
in breast cancer,” Clin Chem Lab Med, 49, pp, 1579–1590, 2011.
302.Panteleakou, Z., Lembessis, P., Sourla, A., Pissimissis, N., Polyzos, A.,
Deliveliotis, C., and Koutsilieris, M., “Detection of Circulating Tumor Cells in
Prostate Cancer Patients: Methodological Pitfalls and Clinical Relevance,” Mol
Med, 15(3-4), pp.101–114,2009.
303.Hanada, M., Aime-Sempe, C., Sato, T., Reed, J.C., “Structure-function analysis of
Bcl-2 protein. Identification of conserved domains important for homodimerization
with Bcl-2 and heterodimerization with Bax,” J. Biol. Chem, 270, pp.11962–11969,
1995.
304.Prabhat, J., Flather, M., Lonn, E., Farkouh, M., and Yusuf, S., “The Antioxidant
Vitamins and Cardiovascular Disease: A Critical Review of Epidemiologic and
Clinical Trial Data,” Annals of Internal Medicine, 123(11), pp. 860–872, 1995.
305.Baillie, J. K., Thompson, A. A. R.., Irving, J. B., Bates, M. G., Sutherland, D.A.I.,
MacNee, W., Maxwell, S. R. J..Webb, D. J., “Oral antioxidant supplementation
does not prevent acute mountain sickness: double blind, randomized placebocontrolled trial,” QJM, 102 (5), pp. 341–348, 2009.
306.Khalid Rahman, “Studies on free radicals, antioxidants, and co-factors,” Clin Interv
Aging, 2(2), pp. 219–236, 2007.
307.Cai, Y., Luo, Q., Sun, M., Corke, H., “Antioxidant activity and phenolic
compounds of 112 traditional Chinese medicinal plants associated with anticancer
activity,” Life Sciences, 74., pp.2157–2184, 2004.
308.Sharmin, H., Nazma, S., Mohiduzzaman, M., Cadi, P.B., “Antioxidant capacity and
total phenol content of commonly consumed selected vegetables of Bangladesh,”
Malays J Nutr, 17(3), pp. 377-383, 2011.
309.Fu, L., BoTao, E., Xu, A., Gan, R.Y., Xu, X.R., Xia, E.Q., and Li, H.B., “Total
Phenolic Contents and Antioxidant Capacities of Herbal and Tea Infusions,” Int J
Mol Sci,12(4), pp.2112–2124,2011.
138
310.Lobo, V., Patil, A., Phatak, A., and Chandra, N., “Free radicals, antioxidants and
functional foods: Impact on human health,” Pharmacogn Rev, 4(8), pp.118–126,
2010.
311.Masella, R., Benedetto, R., Varí, R., Filesi, C., Giovannini, C., “Novel mechanisms
of natural antioxidant compounds in biological systems: involvement of glutathione
and glutathione-related enzymes,” J. Nutr. Biochem. 16, pp. 577–586, 2005.
312.Boddupalli, S., Mein, J. R., Lakkanna, S., and James, D. R., “Induction of Phase 2
Antioxidant Enzymes by Broccoli Sulforaphane: Perspectives in Maintaining the
Antioxidant Activity of Vitamins A, C, and E,” Front Genet, 3(7), 2012.
313.Deb, L., Gupta, R., Dutta, A. S., Yadav, A., “Evaluation of antioxidant activity of
aqueous fraction of Prunus persica L aqueous extract,” Der Pharmacia Sinica, 1 (3),
pp.157-164, 2010.
314.Saboo, S., Tapadiya, R., “In vitro antioxidant activity and total phenolic, flavonoid
contents of the crude extracts of Pterospermum acerifolium wild leaves
(Sterculiaceae),” Journal of Chemical and Pharmaceutical Research, 2(3), pp.417423, 2010.
315.Goyal, A. K., Middha, S. K., Sen, A., “Evaluation of the DPPH radicalscavenging
activity, total phenols and antioxidant activities in Indian wild Bambusa vulgaris
“Vittata” methanolic leaf extracts,” Journal of Natural Pharmaceuticals, 1(1), pp.
40-45, 2010.
316.Mohammadynejad, P., Saadat, I., Ghanizadeh, A., Saadat, M., “Bipolar disorder
and polymorphisms of glutathione S-transferases M1 (GSTM1) and T1(GSTT1),”
Psychiatry Res, 30,186(1), pp.144-146, 2011.
317.Hinchman, C. A., Ballatori, N., “Glutathione conjugation and conversion to
mercapturic acids can occur as an intrahepatic process,” J Toxicol Environ Health,
41(4), pp. 387-409, 1994.
318.Reznick, A.Z, Packer, L., “Oxidative damage to proteins: spectrophotometric
method for carbonyl assay,” Methods Enzymol, 233, pp.357-357, 1994.
319.Cagen, L.M., Pisano, J. J., Ketley, J.N., Habig, W.H., Jakoby, W.B., “ The
conjugation of prostaglandin A1 and glutathione catalyzed by homogenous
glutathione-S-transferases from human and rat liver,” Biochim Biophys Acta, 398,
pp.205–208,1975.
320.Topçuoglu, A.,Uzun, H., Balci, H., Karakus, M., Çoban, I., Altug, T., Aydin, S.,
Topçuoglu, D., Çakatay, U., “Effects of estrogens on oxidative protein damage in
plasma and tissues in ovariectomised rats,” Clin Invest Med. 32 (2), pp.133143,2009.
139
321.Anderson, J.E., Goetz, C.M., McLaughlin, J. L., and Suffness, M., “ A blind
comparison of simple bench-top bioassays and human tumor cell cytotoxicities as
antitumor prescreens,” Phytochemical Analysis, 2, pp.107-111,1991.
322.Mathekga, A.D.M., Meyer, J.J.M., Horn, M.M., Drews, S.E., “An acylated
phloroglucinol antimicrobial properties from Helichrysum caespititum,” J.
Phytochem, 53, pp. 93-96, 2000.
323.Laohavechvanich, P., Muangnoi, C., Butryee, C., and Kriengsinyos, W.,
“Protective effect of makrut lime leaf (Citrus hystrix) in HepG2 cells, Implications
for oxidative stress”, Science Asia., 36, pp. 112–117,2010.
324.Ramaswamy, V., Varghese, N., Simon, A., “An investigation on cytotoxic and
antioxidant properties of clitoria ternatea,” International Journal of Drug Discovery,
3(1), pp. 74-77, 2011.
325.Habig, W. H., Pabst, M. J., and Jakoby, W. B., “Glutathione S transferases the first
enzymatic step in mercapturic acid formation,” J. of Biol. Chem., 249., pp. 7130–
7139, 1974.
326.Ferrandina, G., Scambia, G., Damia, G., Tagliabue,G., Fagotti, A., Panici, P.B.,
Mangioni, C., Mancuso, S., Incalci, M. D., “Glutathione S-transferase activity in
epithelial ovarian cancer: association with response to chemotherapy and disease
outcome,” Ann Oncol, 8, pp.343–350,1997.
327.Tukendorf, A., and Rauser, W. E., “Changes in glutathione and phytochelatins in
roots of maize seedlings exposed to cadmium”. Plant Sci., 70, pp. 155–166, 1990.
328.Hu, M.L., “ Measurement of protein thiol groups and glutathione in plasma,”
Methods Enzymol, 233, pp.380-385, 1994
329.Pelazar, M. J., Chan, E. C. S., and Krieg, N.R., Microbiology: Concepts and
Application, McGrawon Hill Inc. New York, pp. 967, 1993.
330.Samy, R.P., and Ignacimuthu, S., “Antibacterial activity of some folklore medicinal
plants used by tribals in Western Ghats in India”, J. Ethnopharmacol., 69, pp. 6371,2000.
331.Nascimento, G. F. Locatelli, J., Freitas, P. C., Silva, G. L., “Antibacterial activity of
plant extracts and phytochemicals on antibiotic resistant bacteria,” Brazilian Journal
of Microbiology, 31, pp.247-256, 2000.
332.Sung, W.S., and Lee, D.G., “In Vitro Antimicrobial Activity and the Mode of
Action of Indole-3-Carbinol against Human Pathogenic Microorganisms,” Biol.
Pharm. Bull., 30, pp. 1865-1869, 2007.
140
333.Bravo, L., “Polyphenols, Chemistry, dietary sources, metabolism, and nutritional
significance,” Nutr Rev, 56, pp. 317-333, 1998.
334.Trachootham, D., Lu, W., Ogasawara, M.A., DelValle, N. R., and Huang, P.,
“Redox Regulation of Cell Survival,” Antioxid Redox Signal, 10(8), pp.1343–1374,
2008.
335.Waris, G., and Ahsan, H., “Reactive oxygen species: role in the development of
cancer and various chronic conditions,” J Carcinog, 5(14), 2006.
336.Uttara, B., Singh, A. V., Zamboni, P., and Mahajan, R. T., “Oxidative Stress and
Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant
Therapeutic Options,” Curr Neuropharmacol, 7(1), pp.65–74, 2009.
337.Shapiro T. A., Fahey, J.W., Wade, K. L., Stephenson, K. K., Talalay, P.,
“Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts:
metabolism and excretion in humans,” Cancer Epidemiol Biomarkers Prev., 10(5),
pp.501-508, 2001.
338.Yamaguchi, M., “Crucifers in World Vegetables: Principles, Production and
Nutritive Values." AVI Publishing Company, Inc. Westport, Connecticut, pp. 219237, 1983.
339.Xiao, H., Parkin, K. L., “Isolation and identification of potential cancer
chemopreventive agents from methanolic extracts of green onion (Allium cepa),”
Phytochemistry, 68, pp.1059–1067, 2007.
340.Krajinovic, M., Sinnett, H., Richer, C., Labuda, D., Sinnett, D., “Role of NQO1,
MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute
lymphoblastic leukemia,” Int. J. Cancer., 97, pp. 230–236, 2002.
341.Obrador, E., Navarro, J., Mompo, J., Asensi, M., Pellicer, J., and Estrela, J.,
“Glutathione and the rate of cellular proliferation determine tumor cell sensitivity to
tumor necrosis factor in vivo,” Bioch. J, 325 (1), pp. 183-189, 1997.
342.Rahman, I., Gilmour, P. S., Jimenez, L.A., MacNee, W., “Oxidative stress and
TNF-alpha induce histone acetylation and NF-kap-paB/AP-1 activation in alveolar
epithelial cells: potential mechanism in gene transcription in lung inflammation,”
Mol Cell Biochem, 234–235(1-2), pp.239–248, 2002.
343.Juvekar, A. S., Adwankar, M. K,, Tongaonkar, H. B., “Effect of cisplatin-based
chemotherapy on emergence of cisplatin resistance, and its correlation with
intracellular glutathione levels and accumulation of p53 protein in human ovarian
cancer,” Cancer Biother Radiopharm.,15(3), pp.295-300, 2000.
141
344.Townsend, D M., and Tew, K D., “The role of glutathione-S-transferase in anticancer drug resistance”, Oncogene., pp. 227369–227375, 2003.
345.Schnelldorfer, T., Gansauge, S., Gansauge, F., Schlosser, S., Beger, H.G., Nussler,
A.K., “Glutathione depletion causes cell growth inhibition and enhanced apoptosis
in pancreatic cancer cells,” Cancer,89, pp.1440–1447, 2000.
346.Konsue, N., Ioannides, C., “Tissue differences in the modulation of rat cytochromes
P450 and phase II conjugation systems by dietary doses of phenethyl
isothiocyanate,” Food Chem Toxicol, 46, pp.3677–3683, 2008.
347.Hafidh, R. R, Abdulamir, A. S., Vern, L. S., Bakar, F. A., Abas, F., Jahanshiri, F.,
Sekawi, Z., “Inhibition of growth of highly resistant Bacterial and fungal pathogens
by Natural product,” The Open Microbiology Journal, 5, pp.96-106, 2011.
348.Vukovic, N., Milosevic, T., Sukdolak, S., and Solujic, S., “Antimicrobial Activities
of Essential Oil and Methanol Extract of Teucrium montanum,” Evid Based
Complement Alternat Med, 4( 1), pp.17–20,2007.
349.Mayton, S.H., Olivier, C., Vaughn, F.S., Rosemary, L., “Correlation of Fungicidal
activity of Brassica species with Allyl isothiocyanate production in macerated leaf
tissue,” Phytopathology, 86(3), pp.267-271, 1996.
350.Brooijmans, N & Kuntz, I. D. “Molecular recognition and
algorithms,”Annu. Rev. Biophys. Biolmol. Struct. 32, pp.335–373, 2003.
docking
351.Nissink, J. W. M., Murray, C., Hartshorn, M., Verdonk, M. L., Cole, J. C., Taylor,
R., “A New Test Set for Validating Predictions of Protein-Ligand Interaction,”
Proteins, 49, pp.457-471, 2002.
352.Kroemer. R. K., “Structure-Based Drug Design: Docking and Scoring,” Current
Protein and Peptide Science, 8, pp.312-328, 2007.
353.Bikadi, Z., Demko, L., and Hazai, E., “Functional and structural characterization of
a protein based on analysis of its hydrogen bonding network by hydrogen bonding
plot,” Arch. Biochem. Biophys, 461, pp.225-234, 2007.
354.McDonald, I. K., and Thornton, J. M., “Satisfying Hydrogen Bonding Potential in
Proteins,” J Mol Biol, 238, pp.777-793, 1994.
355.Halgren, T. A., “Merck molecular force field. I. Basis, form, scope,
parametrization, and performance of MMFF94,” Journal of Computational
Chemistry, 17 (5-6), pp.490-519, 1998.
142
356.Morris, G. M., Goodsell, D. S., Halliday, R.S., Huey, R., Hart, W. E., Belew, R.
K., and Olson, A. J., “Automated Docking Using a Lamarckian Genetic Algorithm
and Empirical Binding Free Energy Function,” J Comput Chem., 19, 1639-1662,
1998.
357.Solis, F. J., and Wets, R. J. B., “Minimization by Random Search Techniques,”
Mathematics of Operations Research, 6 (1), pp.19-30, 1981.
358.Donepudi, M., Markus, G., “Structure and zymogen activation of caspases,”
Biophysical Chemistry, 101 –102, pp.145–153, 2002.
359.Marabotti, A., and Milanesi, L., “Finding inhibitors of protein-protein interactions
(i-ppis): a support from bioinformatics,” 1(1), pp. 09-20, 2012.
360.Utomo, D. K., Widodo, N., and Rifa, M., “Identifications small molecules inhibitor
of p53-mortalin complex for cancer drug using virtual screening,” Bioinformation,
8(9), pp.426–429, 2012.
361.Wei, B. Q., Weaver, L. H., Ferrari, A. M., Matthews, B. W., and Shoichet. B. K.,
“Testing a Flexible-receptor Docking Algorithm in a Model Binding Site,” J. Mol.
Biol, 337, pp.1161–1182, 2004.
APPENDICES