1. Healthcare

Curriculum Vitae
PERSONAL INFORMATION
Alfonso Cruz-Jentoft
WORK EXPERIENCE
October 1993–Present
Head, Geriatric Department
Hospital Universitario Ramón y Cajal, (Spain)
Health care, education and research within a Geriatric deparment in a University hospital
May 2004–Present
Head, Geriatric Unit
Clínica Ruber, (Spain)
Geriatrician, private practice
February 1992–October 1993
Specialist in Geriatric Medicine
Hospital Clínico San Carlos, (Spain)
Geriatrician in Geriatric Deparment of a University Hospital
EDUCATION AND TRAINING
May 1988–December 1991
Specialist in Geriatric Medicine and Gerontology
Hospital Clínico San Carlos, (Spain)
January 1988–May 2005
PhD
Universidad Complutense de Madrid, (Spain)
Doctoral thesis
ADDITIONAL INFORMATION
Expertise
Publications
Geriatric Medicine. Use of drugs in older people. Discrimination in drug trials of older subjects.
Geriatric nutrition. Sarcopenia. Frailty. Geriatric education.
(Choice of relevant articles only, last five years, 2010-Jan 2015)
- Deutz NE, Bauer JM, Barazzoni R, Biolo G, Boirie Y, Bosy-Westphal A, Cederholm
T, Cruz-Jentoft A, Krznariç Z, Nair KS, Singer P, Teta D, Tipton K, Calder PC.
Protein intake and exercise for optimal muscle function with aging:
recommendations from the ESPEN Expert Group. Clin Nutr. 2014 Dec;33(6):929-36.
doi: 10.1016/j.clnu.2014.04.007. Epub 2014 Apr 24. PubMed PMID: 24814383; PubMed Central
PMCID: PMC4208946.
- García-Gollarte F, Baleriola-Júlvez J, Ferrero-López I, Cuenllas-Díaz Á,
Cruz-Jentoft AJ. An educational intervention on drug use in nursing homes
improves health outcomes resource utilization and reduces inappropriate drug
prescription. J Am Med Dir Assoc. 2014 Dec;15(12):885-91. doi:
10.1016/j.jamda.2014.04.010. Epub 2014 Jun 2. PubMed PMID: 24895001.
- Delgado Silveira E, Montero Errasquín B, Muñoz García M, Vélez-Díaz-Pallarés
M, Lozano Montoya I, Sánchez-Castellano C, Cruz-Jentoft AJ. [Improving drug
prescribing in the elderly: A new edition of STOPP/START criteria.]. Rev Esp
Geriatr Gerontol. 2014 Nov 22. pii: S0211-139X(14)00223-6. doi:
10.1016/j.regg.2014.10.005. [Epub ahead of print] Spanish. PubMed PMID: 25466971.
29/1/15
© European Union, 2002-2014 | http://europass.cedefop.europa.eu
Page 1 / 5
Curriculum Vitae
Alfonso Cruz-Jentoft
- Cruz-Jentoft AJ, Landi F, Schneider SM, Zúñiga C, Arai H, Boirie Y, Chen LK,
Fielding RA, Martin FC, Michel JP, Sieber C, Stout JR, Studenski SA, Vellas B,
Woo J, Zamboni M, Cederholm T. Prevalence of and interventions for sarcopenia in
ageing adults: a systematic review. Report of the International Sarcopenia
Initiative (EWGSOP and IWGS). Age Ageing. 2014 Nov;43(6):748-59. doi:
10.1093/ageing/afu115. Epub 2014 Sep 21. PubMed PMID: 25241753; PubMed Central PMCID:
PMC4204661.
- Flores Ruano T, Cruz Jentoft AJ, González Montalvo JI, López Soto A, Abizanda
Soler P. [Geriatric assessment tools in Spanish Geriatric Departments]. Rev Esp
Geriatr Gerontol. 2014 Sep-Oct;49(5):235-42. doi: 10.1016/j.regg.2014.05.002.
Epub 2014 Jun 19. Spanish. PubMed PMID: 24953247.
- Molina-Garrido MJ, Guillen-Ponce C, Castellano CS, Errasquin BM, Mora-Rufete
A, Cruz-Jentoft AJ. Tools for decision-making in older cancer patients. Role of
the comprehensive geriatric assessment. Anticancer Agents Med Chem. 2014
Jun;14(5):651-6. Review. PubMed PMID: 23438845.
- Cruz-Jentoft AJ, Landi F. Sarcopenia. Clin Med. 2014 Apr;14(2):183-6. doi:
10.7861/clinmedicine.14-2-183. PubMed PMID: 24715131.
- Osuna-Pozo CM, Serra-Rexach JA, Viña J, Gómez-Cabrera Mdel C, Salvá A, Ruiz
D, Masanes F, Lopez-Soto A, Formiga F, Cuesta F, Cruz-Jentoft A. [Prevalence of
sarcopenia in geriatric outpatients and nursing homes. The ELLI study]. Rev Esp
Geriatr Gerontol. 2014 Mar-Apr;49(2):72-6. doi: 10.1016/j.regg.2013.01.006. Epub
2013 Apr 11. Spanish. PubMed PMID: 23583189.
- Cruz Jentoft AJ, Hernández B. [Rivastigmine as treatment for patients with
mild to moderately severe Alzheimer disease under normal clinical practice
conditions. The ENTERPRISE study]. Neurologia. 2014 Jan-Feb;29(1):1-10. doi:
10.1016/j.nrl.2013.01.008. Epub 2013 Apr 10. Spanish. PubMed PMID: 23582372.
- Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips
S, Sieber C, Stehle P, Teta D, Visvanathan R, Volpi E, Boirie Y. Evidence-based
recommendations for optimal dietary protein intake in older people: a position
paper from the PROT-AGE Study Group. J Am Med Dir Assoc. 2013 Aug;14(8):542-59. doi:
10.1016/j.jamda.2013.05.021. Epub 2013 Jul 16. Review. PubMed PMID:
23867520.
- Onder G, Liperoti R, Foebel A, Fialova D, Topinkova E, van der Roest HG,
Gindin J, Cruz-Jentoft AJ, Fini M, Gambassi G, Bernabei R; SHELTER project.
Polypharmacy and mortality among nursing home residents with advanced cognitive
impairment: results from the SHELTER study. J Am Med Dir Assoc. 2013
Jun;14(6):450.e7-12. doi: 10.1016/j.jamda.2013.03.014. Epub 2013 May 4. PubMed
PMID: 23647778.
- Cruz-Jentoft AJ, Carpena-Ruiz M, Montero-Errasquín B, Sánchez-Castellano C,
Sánchez-García E. Exclusion of older adults from ongoing clinical trials about
type 2 diabetes mellitus. J Am Geriatr Soc. 2013 May;61(5):734-8. doi:
10.1111/jgs.12215. Epub 2013 Apr 16. PubMed PMID: 23590338.
- Cruz-Jentoft AJ, Rexach Cano L. [Prognosis of death in end of life care: an
elusive fact or a flawed paradigm?]. Med Clin (Barc). 2013 Mar 16;140(6):260-2.
doi: 10.1016/j.medcli.2012.09.010. Epub 2012 Nov 8. Spanish. PubMed PMID:
23141047.
- Landi F, Cruz-Jentoft AJ, Liperoti R, Russo A, Giovannini S, Tosato M,
29/1/15
© European Union, 2002-2014 | http://europass.cedefop.europa.eu
Page 2 / 5
Curriculum Vitae
Alfonso Cruz-Jentoft
Capoluongo E, Bernabei R, Onder G. Sarcopenia and mortality risk in frail older
persons aged 80 years and older: results from ilSIRENTE study. Age Ageing. 2013
Mar;42(2):203-9. doi: 10.1093/ageing/afs194. Epub 2013 Jan 15. PubMed PMID:
23321202.
- Mijnarends DM, Meijers JM, Halfens RJ, ter Borg S, Luiking YC, Verlaan S,
Schoberer D, Cruz Jentoft AJ, van Loon LJ, Schols JM. Validity and reliability of
tools to measure muscle mass, strength, and physical performance in
community-dwelling older people: a systematic review. J Am Med Dir Assoc. 2013
Mar;14(3):170-8. doi: 10.1016/j.jamda.2012.10.009. Epub 2012 Dec 29. Review.
PubMed PMID: 23276432.
- Cederholm T, Cruz-Jentoft AJ, Maggi S. Sarcopenia and fragility fractures.
Eur J Phys Rehabil Med. 2013 Feb;49(1):111-7. Review. PubMed PMID: 23575205.
- Cruz-Jentoft AJ. Perspective: Protein and exercise for frailty and
sarcopenia: still learning. J Am Med Dir Assoc. 2013 Jan;14(1):69-71. doi:
10.1016/j.jamda.2012.09.024. Epub 2012 Nov 4. PubMed PMID: 23131546.
- Berrut G, Andrieu S, Araujo de Carvalho I, Baeyens JP, Bergman H, Cassim B,
Cerreta F, Cesari M, Cha HB, Chen LK, Cherubini A, Chou MY, Cruz-Jentoft AJ, De
Decker L, Du P, Forette B, Forette F, Franco A, Guimaraes R, Guttierrez-Robledo
LM, Jauregui J, Khavinson V, Lee WJ, Peng LN, Perret-Guillaume C, Petrovic M,
Retornaz F, Rockwood K, Rodriguez-Manas L, Sieber C, Spatharakis G, Theou O,
Topinkova E, Vellas B, Benetos A. Promoting access to innovation for frail old
persons. IAGG (International Association of Gerontology and Geriatrics), WHO
(World Health Organization) and SFGG (Société Française de Gériatrie et de
Gérontologie) Workshop--Athens January 20-21, 2012. J Nutr Health Aging.
2013;17(8):688-93. doi: 10.1007/s12603-013-0039-2. PubMed PMID: 24097023.
- Baztán Cortés JJ, Vidán Astiz MT, López-Dóriga P, Cruz-Jentoft AJ, Petidier
Torregrosa R, Gil Gregorio P, Serra Rexach JA. [Which patients benefit the most
from hospital geriatric care in the opinion of the geriatricians?]. Rev Esp
Geriatr Gerontol. 2012 Sep-Oct;47(5):205-9. doi: 10.1016/j.regg.2012.02.004. Epub
2012 Apr 25. Spanish. PubMed PMID: 22537916.
- Sánchez Castellano C, Cruz Jentoft AJ. [Medications: a double edged sword].
Rev Esp Geriatr Gerontol. 2012 Jul-Aug;47(4):141-2. doi: 10.1016/j.regg.2012.03.005. Epub 2012 Jun
7. Spanish. PubMed PMID: 22683096.
- Cruz-Jentoft AJ, Boland B, Rexach L. Drug therapy optimization at the end of
life. Drugs Aging. 2012 Jun 1;29(6):511-21. doi: 10.2165/11631740-000000000-00000. Review.
PubMed PMID: 22642784.
- Delgado Silveira E, Alvarez Díaz A, Pérez Menéndez-Conde C, Muñoz García M,
Cruz-Jentoft A, Bermejo Vicedo T. [Results of integrating pharmaceutical care in
an Acute Geriatric Unit]. Rev Esp Geriatr Gerontol. 2012 Mar-Apr;47(2):49-54.
doi: 10.1016/j.regg.2011.11.012. Epub 2012 Mar 3. Spanish. PubMed PMID: 22385587.
- García-Gollarte F, Baleriola-Júlvez J, Ferrero-López I, Cruz-Jentoft AJ.
Inappropriate drug prescription at nursing home admission. J Am Med Dir Assoc.
2012 Jan;13(1):83.e9-15. doi: 10.1016/j.jamda.2011.02.009. Epub 2011 Mar 30.
PubMed PMID: 22208763.
- Gallagher P, Lang PO, Cherubini A, Topinková E, Cruz-Jentoft A, Montero
Errasquín B, Mádlová P, Gasperini B, Baeyens H, Baeyens JP, Michel JP, O'Mahony
D. Prevalence of potentially inappropriate prescribing in an acutely ill
29/1/15
© European Union, 2002-2014 | http://europass.cedefop.europa.eu
Page 3 / 5
Curriculum Vitae
Alfonso Cruz-Jentoft
population of older patients admitted to six European hospitals. Eur J Clin
Pharmacol. 2011 Nov;67(11):1175-88. doi: 10.1007/s00228-011-1061-0. Epub 2011 May 17. PubMed
PMID: 21584788.
- Mulin E, Leone E, Dujardin K, Delliaux M, Leentjens A, Nobili F, Dessi B,
Tible O, Agüera-Ortiz L, Osorio RS, Yessavage J, Dachevsky D, Verhey FR, Cruz
Jentoft AJ, Blanc O, Llorca PM, Robert PH. Diagnostic criteria for apathy in
clinical practice. Int J Geriatr Psychiatry. 2011 Feb;26(2):158-65. doi:
10.1002/gps.2508. PubMed PMID: 20690145.
Projects
Only recent or active
- Development and clinical trials of a new Software ENgine for the Assessment &Optimization of drug
and non-drug Therapy in Older persons (SENATOR)
Seventh Framework Program HEALTH-F2-2012-305930
- MPI_AGE: Using Multidimensional Prognostic Indices (MPI) to improve cost-effectiveness of
interventions in multimorbid frail older persons (Executive Agency for Health and Consumers,
European Union. Grant Agreement number 2013 12 02)
- SPRINT-T: Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies.
persons (Innovative Medicines Initiative, European Union. Grant Agreement number 115621)
- Identificación de biomarcadores periféricos de sarcopenia en personas mayores que han sufrido
una fractura de cadera. (Fundación Mutua Madrileña).
- A multicenter, randomized, double-blind, parallel-group placebo-controlled study to investigate the
efficacy and safety of RO4602522 versus placebo, used as adjunctive treatment to the
acetylcholinestarase inhibitors donepezil or rivastigmine in patients with moderately severe
Alzheimer’s disease (Mayflower BP28248)
- A multicenter, double-blind, placebo-controlled, randomised, parallel-group phase 3 study to evaluate
the safety and efficacy of masitinib in patients with mild to moderate Alzheimer’s disease (AB 09004)
- Continued Efficacy and Safety Monitoring of Solanezumab, an Anti-Amyloid β Antibody in Patients
with Alzheimer’s Disease (H8A-MC-LZAO b)
- Efecto de la inmunización pasiva en la progresión de la enfermedad de Alzheimer leve:
solanezumab (LY2062430) frente a placebo.(H8A-MC-LZAX)
- Estudio aleatorizado, doble ciego, controlado con placebo y multicéntrico, para evaluar la seguridad
y la eficacia del tratamiento con REGN1033 por vía subcutánea, durante 3 meses en pacientes con
sarcopenia. EC 13/360 - R1033-SRC-1239
- Un estudio de fase 3 , de 12 semanas de duración, multicéntrico, aleatorizado, doble ciego,
controlado con placebo para evaluar la eficacia, seguridad y tolerabilidad de 3 dosis fijas de
brexpiprazol (OPC-34712) en el tratamiento de sujetos con agitación asociada con la demencia del
tipo Alzheimer. EC 14/030 - 331-12-283
Memberships
- Member of the Academic Board (and former President) of the European Geriatric Medicine Society
- Council Member of the International Association of Gerontology and Geriatrics
- Chair of the International Sarcopenia Initiative (former European Working Group on Sarcopenia in
Older People) and the EUGMS SIG on Sarcopenia
- Member of the EUGMS Working Group on Frailty
- Member of the EUGMS Special Interest Group on Pharmacology
- Board member of the European Academy for Medicine and Aging (EAMA)
- Associate Editor of European Geriatric Medicine, member of editorial board of the Journal of
Nutrition, Health and Aging; Ageing Clinical and Experimental Research; and Semergen
- Member of the Scientific Committee of the last EUGMS congresses
Other Relevant Information
Member of the Safety Committee of the Spanish Drug Agency
President of the Spanish Board on Geriatric Medicine
29/1/15
© European Union, 2002-2014 | http://europass.cedefop.europa.eu
Page 4 / 5
Curriculum Vitae
29/1/15
© European Union, 2002-2014 | http://europass.cedefop.europa.eu
Alfonso Cruz-Jentoft
Page 5 / 5