1. Healthcare

To Promote the Science and Art of Medicine and the Betterment of the Public Health
June 20, 2012, Vol 307, No. 23
Pages 2451-2558
June 20, 2012
CLINICIAN’S CORNER
VIEWPOINTS
GRAND ROUNDS
A Lifecycle Approach to the Evaluation
of FDA Approval Methods and Regulatory Actions:
Opportunities Provided by a New IOM Report ......................................... 2491
Preventing
Ventilator-Associated
Pneumonia: Does
the Evidence Support
the Practice? ............................ 2534
N. P. O’GRADY, P. R. MURRAY,
N. AMES
B. M. PSATY, E. M. MESLIN, A. BRECKENRIDGE
Designing Health Care for the Most Common
Chronic Condition—Multimorbidity ............................................................... 2493
M. E. TINETTI, T. R. FRIED, C. M. BOYD
Clopidogrel Efficacy and Cigarette Smoking Status .................................. 2495
P. A. GURBEL, T. D. NOLIN, U. S. TANTRY
Letters
Treatment of Refractory Mesial
Temporal Lobe Epilepsy ............... 2483
A PIECE OF MY MIND
The Cost of Technology ....................................................................................... 2497
R. R. KIELING, A. PALMINI, E. PAGLIOLI;
J. GOMEZ-ALONSO; J. ENGEL JR,
M. P. MCDERMOTT, J. T. LANGFITT
E. TOLL
Posttraumatic Stress Disorder
and Opioid Use
Among US Veterans
Lipid-Related Markers and Cardiovascular Disease Prediction ............. 2499
ORIGINAL CONTRIBUTIONS
THE EMERGING RISK FACTORS COLLABORATION WRITING GROUP
J. A. HERMOS; K. SEAL,
E. KREBS, T. NEYLAN
Rates of Treated and Untreated Kidney Failure
in Older vs Younger Adults ................................................................................ 2507
Sex Differences in Presentation
of Myocardial Infarction
B. R. HEMMELGARN, M. T. JAMES, B. J. MANNS, A. M. O’HARE,
P. MUNTNER, P. RAVANI, R. R. QUINN, T. C. TURIN, Z. TAN,
M. TONELLI; FOR THE ALBERTA KIDNEY DISEASE NETWORK
F. D. LEONARD; K. H. HUMPHRIES,
M. IZADNEGAHDAR, M. H. MACKAY;
J. G. CANTO, R. J. GOLDBERG,
C. I. KIEFE
Challenges of
Do-Not-Attempt-Resuscitation
Orders
G. D. PERKINS, D. PITCHER, J. SOAR;
A. GEORGIOU; C. D. BLINDERMAN,
E. L. KRAKAUER, M. Z. SOLOMON
Prevalence of Alcohol Use Disorders
Before and After Bariatric Surgery ................................................................... 2516
W. C. KING, J.-Y. CHEN, J. E. MITCHELL, M. A. KALARCHIAN, K. J. STEFFEN,
S. G. ENGEL, A. P. COURCOULAS, W. J. PORIES, S. Z. YANOVSKI
SPECIAL COMMUNICATION
Acute Respiratory Distress Syndrome: The Berlin Definition ................. 2526
THE ARDS DEFINITION TASK FORCE
EDITORIALS
Use of Emerging Lipoprotein Risk Factors
in Assessment of Cardiovascular Risk ............................................................. 2540
S. M. GRUNDY
The Acute Respiratory Distress Syndrome: What’s in a Name?
.............. 2542
D. C. ANGUS
Treated and Untreated Kidney Failure in Older Adults:
What’s the Right Balance? .................................................................................. 2545
128 Years of
M. KURELLA TAMURA, W. C. WINKELMAYER
C ONTINUOUS EDITOR IN CHIEF
P UBLICATION Howard Bauchner, MD
(TABLE OF CONTENTS CONTINUED ON PAGE 2459.)
www.jama.com
©2012 American Medical Association. All rights reserved.
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2457
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To Promote the Science and Art of Medicine and the Betterment of the Public Health
June 20, 2012, Vol 307, No. 23
Pages 2451-2558
BOOK AND MEDIA REVIEWS ................................................................................... 2547
Jonas & Kovner’s Health Care Delivery in the United States
(Kovner, Knickman, eds)
REVIEWED BY D. H. HOWARD
Johns Hopkins Diabetes Guide: Treatment and Management of Diabetes
(Saudek et al, eds)
REVIEWED BY M. KORYTKOWSKI
The Psychotherapy of Hope: The Legacy of Persuasion and Healing
(Alarco´n, Frank, eds)
REVIEWED BY W. A. BROWN
Dignity Therapy: Final Words for Final Days (Chochinov)
REVIEWED BY A. R. BARNOSKY
Biren De (1926-2011), You-July ’70,
1970, Indian.
JAMA PATIENT PAGE
Kidney Stones ........................................................................................................... 2557
Humanities
THE COVER .................................. 2466
You-July ’70
A. R. PUNNOOSE
POETRY AND MEDICINE ........... 2467
Family Doctor
D. DOYLE
JAMA 100 YEARS AGO .............. 2469
Medical Economics
An Open Letter
to Presidential Candidates
Reader Service
News and Analysis
MEDICAL NEWS & PERSPECTIVES ........................................................................... 2473
IUDs Effective but Underused Options for Emergency
and Long-term Contraception
Screening Women for Ovarian Cancer Still Does More Harm Than Good
IOM Urges FDA to Be More Aggressive in Monitoring Safety of Approved Drugs
news@JAMA: From JAMA’s Daily News Site
GLOBAL HEALTH ......................................................................................................... 2477
Heat Thwarts HIV
This Week in JAMA ........................ 2461
Prevent Tobacco Deaths
Masthead ....................................... 2463
Evolution of e-Health
Author in the Room
Teleconference ............................... 2467
Archives Journals Abstracts .............. 2471
Correction ...................................... 2489
Online CME Article ......................... 2534
CME Information ............................ 2551
Cuts in Malaria Financing
FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION ..................... 2478
The Epidemiology Workforce in State and Local Health Departments—
United States, 2010
Tuberculosis Outbreak Associated With a Homeless Shelter—
Kane County, Illinois, 2007-2011
Classified Advertising ...................... 2552
Journal Advertiser Index .................. 2555
JAMA Contact Information ............ 2556
JAMA Beyond Print at www.jama.com
Instructions for Authors
http://jama.com/instructions
The Key and Critical Objectives of JAMA
January 4, 2012
All articles published, including editorials,
letters, and book reviews, represent the
opinions of the authors and do not reflect
the official policy of the American
Medical Association or the institution with
which the author is affiliated, unless this is
clearly specified.
Video Interview with Wendy C. King,
PhD, author of Prevalence
of Alcohol Use Disorders
Before and After Bariatric Surgery
www.jama.com
©2012 American Medical Association. All rights reserved.
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Audio Interview with Emanuele
Di Angelantonio, MD, author
of Lipid-Related Markers
and Cardiovascular Disease Prediction
(Reprinted) 2459