Original Articles Volume 138 Part 2 February 2015 Editorial D. M. Kullmann 237 Scientific Commentaries Reports BRAIN_138_2_Cover.indd 1 Letters to the Editor Does dominant pedunculopontine nucleus exist? S. Lam, E. Moro,Y.-Y. Poon, et al. e323 Reply: Does dominant pedunculopontine nucleus exist? B.W. Fling, J. G. Nutt and F. B. Horak e324 Age-dependent penetrance among females with X-linked adrenoleukodystrophy. M. A. Horn, L. Retterstøl, M. Abdelnoor, et al. e325 Reply: Age-dependent penetrance among females with X-linked adrenoleukodystrophy. M. Engelen, M. Barbier, I. M. E. Dijkstra, et al. e326 TUBB4A novel mutation reinforces the genotype–phenotype correlation of hypomyelination with atrophy of the basal ganglia and cerebellum. D. Carvalho, S. Santos, B. Martins, et al. e327 Reply: TUBB4A novel mutation reinforces the genotype–phenotype correlation of hypomyelination with atrophy of the basal ganglia and cerebellum. E. M. Hamilton, N. I.Wolf and M. S. van der Knaap e328 Corrigenda e329, e330, e331, e332 www.brain.oxfordjournals.org Pages 237–503 Physical activity and risk of Parkinson’s disease in the Swedish National March Cohort. F.Yang,Y.Trolle Lagerros, R. Bellocco, et al. 269 Exome sequencing in undiagnosed inherited and sporadic ataxias. A. Pyle,T. Smertenko, D. Bargiela, et al. 276 Adult-onset genetic leukoencephalopathies: A MRI pattern-based approach in a comprehensive study of 154 patients. X. Ayrignac, C. Carra-Dalliere, N. Menjot de Champfleur, et al. 284 Volume 138 Part 2 February 2015 The perplexing conundrum of frontotemporal dementia. J. R. Hodges 498 From Nissl stains to modern concepts of brainstem function. R. John Leigh 501 February 2015 Pathophysiological concepts in the congenital myopathies: blurring the boundaries, sharpening the focus. G. Ravenscroft, N. G. Laing and C. G. Bönnemann 246 Book Reviews Part 2 Review Article Dorsal Column Volume 138 When brawn benefits brain: physical activity and Parkinson’s disease risk. C. M.Tanner and C. L. Comella 238 New hope for the treatment of epilepsy. H. Lerche 240 Can levodopa-induced dyskinesias go beyond the motor circuit? J. C. Rothwell and J. A. Obeso 242 Alterations in structural connectivity may contribute both to the occurrence of tics in Gilles de la Tourette syndrome and to their subsequent control. A. Draper and S. R. Jackson 244 Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2. A. M. Rossor, E. C. Oates, H. K. Salter, et al. 293 Significance of neurovascular contact in classical trigeminal neuralgia. S. Maarbjerg, F.Wolfram, A. Gozalov, et al. 311 Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice. L. S. Mendonça, C. Nóbrega, H. Hirai, et al. 320 Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model. C. Martins, º H. Hulková, L. Dridi, et al. 336 Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering. F. Dachet, S. Bagla, G. Keren-Aviram, et al. 356 Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug. A. Doeser, G. Dickhof, M. Reitze, et al. 371 Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants. R. L. O’Gorman, H. U. Bucher, U. Held, et al. and the Swiss EPO Neuroprotection Trial Group 388 Pivotal role of choline metabolites in remyelination. T. Skripuletz, A. Manzel, K. Gropengießer, et al. 398 A network centred on the inferior frontal cortex is critically involved in levodopainduced dyskinesias. A. Cerasa, G. Koch, G. Donzuso, et al. 414 Improving ideomotor limb apraxia by electrical stimulation of the left posterior parietal cortex. N. Bolognini, S. Convento, E. Banco, et al. 428 Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer’s disease. K. Richetin, C. Leclerc, N.Toni, et al. 440 Why do patients with neurodegenerative frontal syndrome fail to answer: ‘In what way are an orange and a banana alike?’ J. Lagarde, R.Valabrègue, J.-C. Corvol, et al. 456 Altered structural connectivity of corticostriato-pallido-thalamic networks in Gilles de la Tourette syndrome. Y.Worbe, L. Marrakchi-Kacem, S. Lecomte, et al. 472 Evidence for inhibitory deficits in the prefrontal cortex in schizophrenia. N. Radhu, L. Garcia Dominguez, F. Farzan, et al. 483 16-01-2015 12:11:09 www.brain.oxfordjournals.org The following can be found at Brain Online Instructions to authors Submission information eTOC alerting service Register to receive an electronic table of contents by e-mail as each issue is published Free editorials Editorials from the current and previous issues are freely available Grants, bursaries and financial support Details of travel grants, the Visiting Lecturer Bursary Scheme and support for trainee neurologists Subscriptions A subscription to Brain comprises 12 issues. Prices include postage by surface mail, or for subscribers in the USA and Canada by airfreight, or in India, Japan, Australia and New Zealand, by Air Speeded Post. Airmail rates are available on request. Brain Advance Access contains papers that have been finalised, but have not yet been included within an issue. Advance Access is updated weekly. 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