1. No category

SEMINARIOS DE INVESTIGACIÓN
(Marcar la opción que proceda)
 Ot
☒ SEMINARIO financiado con la Convocatoria de Movilidad de Movilidad de Investigadores Externos
Máster Oficial (Comisión de Estudios de Posgrado)
☐ OTROS SEMINARIOS
NOTA: Este Anexo ha de remitirse a [email protected]
La no cumplimentación exhaustiva de alguno estos datos supondrá la devolución al
remitente.
ANEXO B : Información para la difusión del seminario1
Título: Microglía and the hipoxia signaling pathway. Implications for Alzheimer’s disease.
Ponente: Alberto Pascual Braco
Fecha/Hora: 27 de octubre a las 16:00 h
Lugar: Biblioteca del Departamento de Farmacología- 1º Planta
Contenido del seminario
Ámbito:
Programa de Doctorado en:
Línea/Tema de investigación:
Farmacología y Fisiologia
Neurociencias
Breve resumen (max. 150 palabras):
AD is characterized by a pathognomonic early decrease in brain blood flow, the
accumulation of the Abeta peptide in the wall of brain vessels (amyloid angiopathy), and
a high local inflammation surrounding senile plaques. These three circumstances lead to a
local decrease in oxygen concentration that could modify the progression of AD. Indeed,
we have shown that human AD brains show molecular indications of hypoxia. We have
also revealed that the accumulation of HIFalpha factors produces microglia cell cycle
arrest and worsens AD pathology in animal models of AD. We have identified PHD3, a HIF
target gene, as another contributor to AD neurodegeneration. Genetic deletion of PHD3
recovers cognitive and behavioral phenotypes of an AD mouse model and change the
activation profile of microglia.
Ponente: Breve resumen del CV (max. 200 palabras):
Graduated in Biology in 1994 with maximal academic honors, the PI of the present project
worked in his PhD for 4 years (1995-1998), with a fellowship from the Spanish Ministry for
Science and Education. He published 4 papers as a first author with only his PhD
supervisor as a second author (corresponding) in journals of medium-high impact like
PNAS. The PI moved to “Institut Alfred Fessard” at Gif-sur-Yvette, France where
performed a postdoctoral stage of 4 years (1999-2002, EMBO and FRM fellowships),
under the supervision of Dr. Thomas Préat. He published five papers as a first author
1
La información sobre el seminario no debe superar una página
1
SEMINARIOS DE INVESTIGACIÓN
including
two Science and one Nature article. The PI obtained a competitive contract to
 Ot
return to Spain (Ramón y Cajal, Spanish Ministry of Science) associated with Prof. LópezBarneo in a Hospital in Seville (2003). During this time, the PI got a permanent position at
the Spanish Research Council (CSIC) to become an independent researcher (2007). He was
selected as PI of the Instituto de Biomedicina de Sevilla (IBiS) during 2008 and gained
research space in 2011. His main line of research is related with Alzheimer’s disease (AD)
and the hypoxia-signaling pathway.
2