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Curriculum vitae Lorenzo Romero Ramírez
ACADEMIC DEGREES
Degrees in Biochemistry (MS and BS). School of Sciences. Universidad de Navarra (Spain). 1994.
Ph. D. in Molecular Biology. School of Sciences. Universidad Autónoma de Madrid (Spain). 2001.
CURRENT PROFESSIONAL ACTIVITY
Staff Researcher. Starting date: March 2008 Organization: SESCAM. Institution: National Hospital
for Paraplegics, Experimental Neurology Unit. e-mail: [email protected]
PREVIOUS PROFESSIONAL ACTIVITIES
Job title
Research Associate
Institution
Date
Dept. Radiation Oncology, Stanford University, USA Nov.2006- Oct.2007
Postdoctoral fellow
Dept. Radiation Oncology, Stanford University, USA Nov.2001-Oct.2006
SELECTED PUBLICATIONS
Barreda-Manso MA, Yanguas-Casás N, Nieto-Sampedro M, Romero-Ramírez L. (2015) Salubrinal
inhibits the expression of proteoglycans and favors neurite outgrowth from cortical neurons in vitro.
Exp Cell Res. 335(1):82-90. doi: 10.1016/j.yexcr.2015.04.002
Romero-Ramírez L, García-Álvarez I, Casas J, Barreda-Manso MA, Yanguas-Casás N, NietoSampedro M, Fernández-Mayoralas A. (2015) New oleyl glycoside as anti-cancer agent that targets
on neutral sphingomyelinase. Biochem Pharmacol. 97(2):158-72. doi: 10.1016/j.bcp.2015.07.009.
Yanguas-Casás N, Barreda-Manso MA, Nieto-Sampedro M, Romero-Ramírez L. (2014)
Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute
neuroinflammation. J Neuroinflammation. 11:50. doi: 10.1186/1742-2094-11-50.
Romero-Ramírez L, García-Álvarez I, Campos-Olivas R, Gilbert M, Goneau MF, FernándezMayoralas A, Nieto-Sampedro M. (2012) Specific synthesis of neurostatin and gangliosides Oacetylated in the outer sialic acids using a sialate transferase. PLoS One. 7(12):e49983. doi:
10.1371/journal.pone.0049983.
García-Álvarez I, Groult H, Casas J, Barreda-Manso MA, Yanguas-Casás N, Nieto-Sampedro M,
Romero-Ramírez L*, Fernández-Mayoralas A*. (2011) Synthesis of antimitotic thioglycosides: in
vitro and in vivo evaluation of their anticancer activity. J Med Chem. 54(19):6949-55. doi:
10.1021/jm200961q.. * Corresponding authors.
ACADEMIC ACTIVITES
Ph.D. theses supervised
Natalia Yanguas Casás (2015): “Effect of tauroursodeoxycholate in the regulation of acute
neuroinflammation”. Ph.D. program on Biochemistry, Molecular Biology, Biomedicine and
Biotechnology. Department of Biochemistry. School of Medicine. Universidad Autónoma de Madrid.
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International doctorate with best qualification “cum laude”. Supervisors: Lorenzo Romero Ramírez
and Manuel Nieto Sampedro.
Ongoing Ph.D. theses
Mª Asunción de la Barreda Manso. “Effect of salubrinal on the glial scar formation after an injury to
the Central Nervous System”. Ph.D. program on Biochemistry, Molecular Biology and Biomedicine.
Department of Biochemistry and Molecular Biology. School of Biological Sciences. Universidad
Complutense de Madrid. Date of defense: 9/28/2015. Supervisors: Lorenzo Romero Ramírez and
Manuel Nieto Sampedro.
Master’s thesis supervised
Aroa Martínez Vázquez (2014). “Structure-function study of neurostatin and other gangliosides on
the inhibition of nitrites production in the microglia cell line BV-2”. Master’s program in Genetics and
Cellular Biology. School of Cellular Biology and Genetics. Universidad de Alcalá de Henares. Grade:
Outstanding. Supervisors: Lorenzo Romero Ramírez and Manuel Nieto Sampedro.
Estela Dámaso Riquelme (2013). “Effect of neurostatin and other inhibitors of cell proliferation in
glioblastomas”. Master’s program in Genetics and Cellular Biology. Universidad de Alcalá de
Henares. Grade: Outstanding. Supervisors: Lorenzo Romero Ramírez and Manuel Nieto Sampedro.
Mª Asunción de la Barreda Manso (2011). “Pharmacological modulation of the inhibition of axonal
regeneration by the glial scar in an injury of cerebral cortex”. Master’s program in Biochemistry,
Molecular Biology and Biomedicine. School of Chemical Sciences. Universidad Complutense de
Madrid Grade: Outstanding. Supervisors: Lorenzo Romero Ramírez and Manuel Nieto Sampedro.
FUNDING IN THE LAST YEARS
Title of the Project: Mode of action of gangliosides inhibitors of neuroinflammation and glial reactivity
after an injury of the CNS. Funding organization: Plan Nacional (SAF2012- 40126). From 2013 to
2015. Principal Investigator: Manuel Nieto-Sampedro.
Title of the Project: Pharmacological modulation of the glial scar for the regeneration of CNS injuries.
Funding organization: Fundación MAPFRE. From January 2013 to December 2013. Principal
Investigator: Manuel Nieto-Sampedro.
Title of the Project: Control of neuroinflammation and glial reactivity after spinal cord injury. Funding
organization: Plan Nacional (SAF2009-11257). From 2010 to 2012. Principal Investigator: Manuel
Nieto-Sampedro
Title of the Project: Pharmacological modulation of the inhibition of axonal regeneration by the glial
scar in an injury of the cerebral cortex. Funding organization: FISCAM-Castilla La Mancha
From 2009 to February 2012.
Reference: PI2008/19. Principal Investigator: Manuel Nieto
Sampedro.
Title of the Project: A transgenic model to study the role of TGFβ in the generation of reactive glia
and its therapeutica inhibition after brain injuries. Funding organization: FISCAM . From 2010 to
2012. Reference: PI2009/51. Principal Investigator: Lorenzo Romero Ramírez
Title of the Project: Pharmacological modulation of the inhibition of axonal regeneration by the glial
scar in an injury of the cerebral cortex. Funding organization: FISCAM-Castilla La Mancha
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(PI2008/19). From 2009 to February 2011. Reference: PI2008/19. Principal Investigator: Manuel
Nieto Sampedro
PATENTS
Inventors: Hugo Groult; Jesús Ruiz-Cabello; Fernando Herranz Rabanal; Alfonso Fernández
Mayoralas; Manuel Nieto Sampedro; Lorenzo Romero Ramírez; Isabel García Álvarez. Title:
Superparamagnetic nanoparticle micelles containing antitumoral glycosides. Registry #:
EP14382093.4. European patent. Date: 01/15/2014. Organizations: CSIC-CNIC-CIBERES.
Inventors: A. Fernández-Mayoralas, M. Nieto Sampedro, Josefina Casas Brugulat, Isabel García
Álvarez, Lorenzo Romero Ramírez. Title: Derivados de n-trifluoroacetilhexosaminas y su uso como
inhibidores de la división de células tumorales. Application #: P201230510. National patent. Date: 3
April 2012 Organizations: CSIC, FUHNPAIIN.
Inventors: M. Nieto Sampedro, Lorenzo Romero Ramírez. Title: Inhibidores de la división de células
tumorales . Application #: P201031552. National Patent.
Registry #.
ES1641.823,
PCT/ES2011/070732. Date: 21 October 2011 Organizations: CSIC, FUHNPAIIN.
Inventors: A. Fernández-Mayoralas, M. Nieto Sampedro, Josefina Casas Brugulat, Isabel García
Álvarez, Lorenzo Romero Ramírez. Title: Derivados azufrados de n-acetilhexosaminas y su uso
como inhibidores de la división de células tumorales. Application #: P201030366. National Patent.
Registry #. PCT/ES2011/070169. Date: 11 March 2011. Organizations: CSIC, FUHNPAIIN.
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