IMPLEMENTACION DECODIGOROJO OBSTETRICO 1 A California Toolkit to Transform Maternity Care Improving Health Care Response to Obstetric Hemorrhage THIS COLLABORATIVE PROJECT WAS DEVELOPED BY: THE OBSTETRIC HEMORRHAGE TASK FORCE THE MATERNAL QUALITY IMPROVEMENT PANEL CALIFORNIA MATERNAL QUALITY CARE COLLABORATIVE MATERNAL, CHILD AND ADOLESCENT HEALTH DIVISION; CENTER FOR FAMILY HEALTH CALIFORNIA DEPARTMENT OF PUBLIC HEALTH jour nal homepage: www. elsevier.com/locate/ijgo Rosemarie Fernandez, MD P CLINICAL ARTICLE ostpartum hemorrhage (PPH) is the leading cause of ma- management of the PPH p ternal mortality worldwide, contributing to approximately (nonoperative) managem 140,000 deaths per year.1 Because of readily available medical decompensating patient. F and surgical management, the number of deaths in the United for the (1) identification o States is low; nonetheless, PPH remains a leading cause of behaviors and (2) detectio pregnancy-related morbidity and mortality. Early recognition ficiencies before an actual of known risk factors for PPH and the use of third-stage in- the development, content a, b b b travenous oxytocin have been shown to significantly lower the tionbof a standardized pa incidence of PPH.2Y4 Unfortunately, diagnosing clinically sig- scenario. The training rec nificant PPH is notoriously difficult because health care pro- University of Washington a St George's University, London, UK viders typically underestimate blood loss and, in pregnancy, b Department of Obstetrics and Gynecology, St George's Healthcare NHS Trust, London, UK signs of hypovolemia are also delayed. Appropriate management of PPH therefore typically requires an urgent interdis- PARTICIPANTS/LEARN Report/Simulation ciplinary coordinated effort to safely administer aCasevariety of Scenario This simulation invo medications and perform any necessary procedures to stop residents (n = 19), obstet anesthesiology residents ( the patient’s blood loss. article info abstract 425-452) In situ simulation of PPH is a particularly valuable pro- ing physicians (n = 5). A cess. First and foremost, it provides a platform for interdis- still successfully complete Article history: Objective: To evaluate whether the algorithm “HEMOSTASIS” (help; establish the uterus; Artículo de revisión position consists of 6 to 8 ciplinary team practice whileetiology; maintaining massage the environmental Received 3 June 2010 3 disciplines/specialties oxytocin infusion and prostaglandins; shift to operating theater; tamponade test; apply and system factors present during actualcompression patient care events.sutures; Received in revised form 5 November 2010 Second, it allows the entire interdisciplinary team to practice wassia.) systematic pelvic devascularization; interventional radiology; subtotal/total abdominal hysterectomy) ofA total of 83 learner Medical Center Labor an Accepted 27 January 2011 value in the systematic management of postpartum hemorrhage (PPH). Methods: A retrospective analysis was the scenario. Outcome of the management of massive postpartum hemorrhage using the algorithm “HEMOSTASIS” Lavanya Varatharajan ⁎, Edwin Chandraharan , Julian Sutton , Virginia Lowe , Sabaratnam Arulkumaran An In Situ Standardized PatientYBased Simulation to Train Postpartum Hemorrhage and Team Skills on a Labor and Delivery Unit Guía de práctica clínica paraperformed of all women who experienced massive Michael F. Fialkow, MD;primary PPH (blood loss N1500 mL) in 2008 at St George's of the HEMOSTASIS mnemonic in PPH management was determinedSCENARIO by DEVELOPME la prevención y el manejO deHospital, la London, UK. The successChristine R. Adams, BSN; assessing clinical outcome following adherence to the protocol. Results: Patient notes were available Needs for Assessment and Lea Leslie Carranza, MD; 95 (83.3%) of the 114 cases of primary PPH. Hemostasis was achieved in 63 (66.3%) women via use ofA robust needs assess hemOrraGia pOspartO y cOmplicaciOnes viaJ. suture of tears and 10 (10.5%) via tamponade (“T”); 1 (1.1%) ofviaeffective training pro Simon Golden, BS; 1 additional oxytocics (“O”); 19 (20.0%) began with a need del chOque hemOrráGicO application of compression suture (“A”); 1 (1.1%) via systematic devascularization (“S”); and 1 (1.1%) ment via Washington Medical Cen From the Division of Emergency Medicine (R.F.), and Department of Obstetrics and Gynecology (M.F.F., L.C., T.J.B.), University of Washington School of Medicine, Washington, DC; University of Washington Medical Center (C.R.A.), Seattle, WA; Department of Obstetrics and Gynecology (L.C.), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Psychology (S.J.G.), Michigan State University, East Lansing, MI. Reprints: Michael Fialkow, MD, Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 NE Pacific St, Box 356460, Seattle, WA 98195 (e<mail: [email protected]). The authors declare no conflict of interest. Keywords: Cesarean delivery Hemostasis Hysterectomy Postpartum hemorrhage Thomas J. Benedetti, MD; FIGURE 1. Scenario flow and prompts.hysterectomy (“S”). FIGURE Scenario flow deaths. and prompts. subtotal/total There 1. were no maternal Conclusion: The decremental patternticipating of disciplines (nu This process focused on Fernandez,that MD the algorithm can provide a logical management pathway clinical practice guidelines for the more prevention complex interventions usedRosemarie demonstrates clinical objectives. Traini to reduce blood transfusions, hysterectomies, admissions to intensive care units, and maternal deaths. procedural skills were no and management of post-partum bleeding and Crown Copyright © 2011 Published Elsevier Ireland Ltd. on Federation of Gynecology were therefore not a com Vol. 9, Number 1, February 2014 Vol. by 9, Number 1, February 2014behalf of* International 2014 Society for Simulation in Healthcare 67 and Obstetrics. All rights reserved. of hemorrhagic shock complications Postpartum hemorrhage (PPH) is the leading cause of ma- management of the PPH patient, including diagnosis, medical This study was supported by the Department of Defense US Army Medical Research and Material Command under award number W81XWH-10-2-0023. Views and opinions of, and endorsement by the author(s) do not reflect those of the US Army or the Department of Defense. Copyright * 2014 Society for Simulation in Healthcare DOI: 10.1097/SIH.0000000000000007 Vol. 9, Number 1, February 2014 ternal in mortality worldwide,Unauthorized contributing to©approximately (nonoperative) and resuscitation of the acutelyUnauthorized repr Copyright © 2014 by the Society for Simulation Healthcare. Copyright 2014 reproduction by theCopyright ofSociety this© article formanagement, Simulation is prohibited. in Healthcare. 2014 by the Society for Simulation in Healthcare. Unauthorized reproduction Representantes del Grupo Desarrollador de la Guía - Universidad Nacional de Colombia - Alianza Cinets* 1. Introduction Recibido: agosto 20/13 – Aceptado: noviembre 8/13 The success of modern obstetrics continues to be challenged 140,000 deaths per year.1 Because of readily available medical decompensating patient. Finally, the debriefing process allows and surgical management, the number of deaths in the United for the (1) identification of gaps in knowledge and teamwork States is low; nonetheless, PPH remains a leading cause of behaviors and (2) detection of environmental and system depregnancy-related and mortality. Early recognition London, ficiencies before adverse event. article describes staff atmorbidity St George's Hospital, UK,an actual so that eachThisstep in the of known risk factors for PPH and the use of third-stage in- the development, content validation, and in situ implementaalgorithm would followed rapid succession untilinterdisciplinary bleedingPPH was travenous oxytocin have been shown to be significantly lower the in tion of a standardized patient-based, 2Y4 of PPH. Unfortunately, diagnosingofclinically scenario. received expedited approval from The details eachsig-stage of The thetraining updated mnemonic aretheas by incidencearrested. CODIGOROJOOBSTETRICO OBJETIVOS • Diagnos(carchoqueenhemorragiaobstétrica. • Ac(varelcódigorojoobstétrico. • Asignarfunciones-roles. • AplicarelABCDEdelareanimación. • Definirlascondicionesparamanejoycuidadodefini(vo. • Remisión–SalasdeCirugía–CuidadoIntensivo DIAGNOSTICODELCHOQUEHIPOVOLEMICO Perdida devolumen (%)ymlparauna mujerentre 50-70Kg Sensorio Perfusión Pulso 10-15% 500-1000mL Normal Normal 60-90 >90 Compensado Usualmente norequerida 16-25% 1000-1500mL Normaly/o agitada Palidez,frialdad 91-100 80-90 Leve Posible Agitada Palidez,frialdad,más sudoración 101-120 70-79 Moderado Usualmente requerida Letárgicao inconciente Palidez,frialdad,más sudoraciónyllenado capilar>3segundos Severo Transfusión Masiva probable 26-35% 1500-2000mL >35% >2000mL >120 Presión Arterialsistólica Gradodelchoque (mm/Hg) <70 Trasfusión Evaluacióndelgradodechoquehemorrágicoualizando Paralaclasificaciónelparametromasalterado ACTIVACIONDELCODIGOROJO OBSTETRICO Donde? Como? Quien? Haycódigo rojoenel hospital? Cualesel sistemade ac(vación? Cualesel equipo? • Obstetra • Anestesiólogo • Enfermería(jefe) • Enfermería(auxiliar) • Instrumentadora • Camillero • Laboratorioclínicoyserviciodetransfusión • Salasdecirugía • Cuidadosintensivos • Transporte. EQUIPO MANAGEMENTOFMASSIVEPOSTPARTUMHEMORRHAGE ORGANIZINGTHETEAM Cabeza Utero Brazos Cabeza • • • • Chequeeviaaerea. Administreoxigeno Vigileestadodeconciencia Tome(empodelossucesos Brazos Utero • • • • • • • • • • • • • ManagementofMassive POSTPARTUMHEMORRHAGE OrganizingtheTeam Chequeepulsos Canalizardosvenasdegruesocalibre. Realizarlaboratorios Cruzar4-6unidades RepongaperdidasconbolosdeLEV Inicieoxitocina,metergyn,misoprostol Inicieaquí Pidaayudantes Ayudante1encabeza Ayudante2y3enbrazos Realizarmasajebimanual Piense4’tsparamanejo PienseenCirugíaoportuna ASIGNACIONDE FUNCIONES Cabeza. Brazoizquierdo. Pelvis. Registro No1 No2 No2 No1 COMUNICACIÓNENCRISIS CODIGOROJOOBSTETRICO ABCDE A: Víaáreapermeable B: Ven(laciónadecuada–O2suplementario. C: Pareelsangrado–Accesosvenosos2–tomade muestrasUsodeFluidos(definirrespondedorono respondedor)–Fármacos–UsodeHemoderivados D: Diagnós(cos:4T’s E: Evitarhipotermia. CODIGOROJOOBSTETRICO ABCDE A: Víaáreapermeable B: Ven(laciónadecuada–O2suplementario. C: Pareelsangrado–Accesosvenosos2–tomade muestrasUsodeFluidos(definirrespondedorono respondedor)–Fármacos–UsodeHemoderivados D: Diagnós(cos:4T’s E: Evitarhipotermia. CODIGOROJOOBSTETRICO ABCDE A: Víaáreapermeable B: Oximetríadepulso–Ven(laciónadecuada–O2suplementario - • Mascaraconbolsareservorio 10Lt/min. CODIGOROJOOBSTETRICO ABCDE Víaaérea Venalación CODIGOROJOOBSTETRICO ABCDE A: Víaáreapermeable B: Ven(laciónadecuada–O2suplementario. C: Pareelsangrado–Accesosvenosos2–tomade muestrasUsodeFluidos(definirrespondedorono respondedor)–Fármacos–UsodeHemoderivados D: Diagnós(cos:4T’s E: Evitarhipotermia. C:Pareelsangrado CODIGOROJOOBSTETRICO ABCDE C:Posición CODIGOROJOOBSTETRICO ABCDE C:AccesosvenososNo.2-Calibre Diámetro 14-16 corto CODIGOROJOOBSTETRICO ABCDE C:AccesosvenososNo.2-Ubicación CODIGOROJOOBSTETRICO ABCDE C: AccesosvenososNo.2–Tomademuestras(Lab–BancodeSangre) CODIGOROJOOBSTETRICO ABCDE C:AccesosvenososNo.2 Cristaloides Calientes SSN–LR Bolos500ml Evaluarrespuesta EVALUACIÓNRESPUESTAAINFUSIONDEVOLUMEN CRISTALOIDES500ml. Respuestarápida Respuestatransitoria Norespuesta Retornaalonormal Hipotensiónrecurrente (PAS<90mmHg);sensorio comprome(do;pulsoradial débil;taquicardia Permanecenanormalesono seconsiguenmetasenningún momento 10-25%ó500-1500mL (choquecompensadooleve) 26-40%ó1500-2000mL (choquemoderado) Transfusiónimprobable Probable Paqueteglobularde emergencia:2UGRE Paquetetransfusionalde emergencia:4UGRE/6UPFC/ 6UPLT,ABOcompa(bles Paqueteglobularde emergencia(poespecífica sinpruebascruzadas(15 minutos).Encasodeno disponibilidad,O-uO+ Inmediato:paqueteglobular O-(uO+);PFCO-(uO+);PLT ORhcompa(bles Sangre(pocompa(blecon pruebascruzadas (45-60minutos) >40%ó>2000mL (choquesevero) NODARCARGASPREDETERMINADASDE1-2lt. Evitarfórmulasdees(maciónpararemplazos.3:1 Bolos500cc.CristaloidesIVa39ºc Pulsoradial–sensoriointacto Tipoderespuesta Parámetrosclínicos Intervención Mejoríasostenida Ningunaadicional Mejoríaparcial Retosdevolumen Cristaloides/coloides Nomejoraconretos Devolumen Hemoderivados Cirugia Ningunarespuesta Controlquirúrgicoinmediato CODIGOROJOOBSTETRICO ABCDE C: MedidasFarmacológicasparapararelsangrado. Uterotonicos • Oxitocina • Methergina • Misoprostol Ac.Tranexamico WHO recommendations for the prevention and treatment of postpartum haemorrhage • Masaje uterino externo de forma con(nua y permanente durante el manejo integral y hasta queelsangradohayacedido • Masaje uterino bimanual durante al menos 20 minutos o hasta que haya cedido el sangrado cuandoelmasajeuterinoexternohasidoineficaz • Oxitocina a dosis de 80 miliunidades por minuto: 20 U diluidos en 500mL de SSN 0.9% para pasaren4horas(a125mL/horaporbombadeinfusión;20gotasminutopormacrogotero10 gotas=1ccó125microgotasminutopormicrogoterode60microgotas=1cc). • Methergynampx0,2mg:1ampollaIM,seguidaporotradosisalos20minutosydespués0,2 miligramosIMcada4horashastauntotalde5dosiscomodosismáximaen24horas(sinohay hipertensión). • Misoprostol 800 mcg por vía sublingual solo si no se cuenta con oxitocina o maleato de me(lergonovina ACIDOTRANEXAMICOENHEMORRAGIAOBTETRICA • El ácido tranexámico se puede ofrecer como un tratamiento para hemorragia posparto si la administración de UTEROTÓNICOS no ha sido efec(va o como complemento a la sutura de trauma(smos del canaldelpartoodelútero. • Dosis:1grporvíaIVen1min • Sepuederepe(r(1grIV)alos30minutos • Temprano:primeras3horas CODIGOROJOOBSTETRICO ABCDE C:medidasfarmacológicasparaprevenirlainfección An(bió(cos • Ampicilina-Gentamicina • Cefazolina1gr • Clindamicina600mgIV CODIGOROJOOBSTETRICO ABCDE C:Hemoderivados Paquetedetransfusióndeglóbulos rojosdeemergencia: 2ugreo(-)ó2ugreo(+) Sinpruebascruzadas CODIGOROJOOBSTETRICO ABCDE C:Hemoderivados PROTOCOLODETRANSFUSIÓNMASIVA: GRE:PFC:plaquetas,1:1:1 GRE6unidades,PFC6unidades,1aféresisó6unidadesdeplaquetas American Journal of Obstetrics & Gynecology.2011: 205:6 526-532 International Journal of Obstetric Anesthesia (2013) 22, 87–91 0959-289X/$ - see front matter c 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.ijoa.2013.01.002 ! EDITORIAL www.obstetanesthesia.com Postpartum hemorrhage and low fibrinogen levels: the past, present and future International Journal of Obstetric Anesthesia (2013) 22, 87–91 ! 0959-289X/$ - see front matter c 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.ijoa.2013.01.002 • ‘‘Change Fibrinógeno es parámetro de laboratorio independientemente and initiating fibrin polymerization afterasociado undergoing is the law of life. And those who look only to the 9 by thrombin (secondary hemostasis). A review el are desarrollo HPP masiva cleavage y niveles menores de 2 g/L son pastcon or present certain to missde the future.’’ of studies thatriesgo have reported plasma fibrinogen Johnindependiente F. Kennedy EDITORIAL asociados con incremento en el de HPP masiva OR concentrations in pregnant women indicates that these Are 12.0,95%ci2.6–56.1 rates and outcomes after postpartum hemorrhage levels are higher in pregnant women compared to non- (PPH) getting any better? Well . . . there is some good news pregnant women (Table 1). Fibrinogen levels increase and bad news. According to recent maternal mortality rewith advancing gestation and are most pronounced in 10–16 views, the good news is that the proportion of maternal • Cambios del protocolo de Transfusión masiva en obstetriciachanges con the third trimester. Pregnancy-associated deaths due to hemorrhage appears to be decreasing: in fibrinogen are likely due to an increase in estrogen lev3.4%CrioprecipitadoyCoadyuvantes and 12% of maternal deaths in the UK (2006– els with advancing gestational age. In the postpartum per2008)1 and in the US (1998–2005),2 respectively. The iod, a mild-moderate decrease in maternal fibrinogen bad news is that rates of PPH appear to be steadily levels occurs after removal of the placenta,17 which may 3 increasing in many high-resource countries, which have persist into the early period after delivery.18,19 been linked to an accompanying increase in maternal A number of important studies have provided eviand initiating Postpartum hemorrhage and low fibrinogen present and future 4 ‘‘Change is the law of life. And those who look only to the fibri REANIMACIONHEMOSTATICA • PAQUETEDETRANSFUSIÓNDEGLÓBULOSROJOSDEEMERGENCIA: • 2UGREO(-)ó2UGREO(+)sinpruebascruzadas • PROTOCOLODETRANSFUSIÓNMASIVA:GRE:PFC:plaquetas,1:1:1 • GRE6unidades,PFC6unidades,1aféresisó6unidadesdeplaquetas • Crioprecipitado 10-20unidades • Concentradosdefibrinogeno 2Gramos. • Acidotranexamico. 1Gramo. CODIGOROJOOBSTETRICO ABCDE A: Víaáreapermeable B: Ven(laciónadecuada–O2suplementario. C: Pareelsangrado–Accesosvenosos2–toma demuestrasUsodeFluidos(definirrespondedorono respondedor)–Fármacos–UsodeHemoderivados D: Diagnós(cos:4T’s E: Evitarhipotermia. CODIGOROJOOBSTETRICO ABCDE Enfoquedelas4t’s: Tono Trauma Tejido Trombina CODIGOROJOOBSTETRICO ABCDE A: Víaáreapermeable B: Ven(laciónadecuada–O2suplementario. C: Pareelsangrado–Accesosvenosos2–toma demuestrasUsodeFluidos(definirrespondedorono respondedor)–Fármacos–UsodeHemoderivados D: Diagnós(cos:4T’s E: Evitarhipotermia. CODIGOROJOOBSTETRICO ABCDE E:Evitarhipotermia. TROMBOPROFILAXIS CODIGOROJOOBSTETRICO HORADORADADELAREANIMACION Hemorragiapostparto Obstetra Anestesiólogo Diagnos(co4Ts Masajeuterino Manejomedico Monitoria Laboratorios 2accesosEV BolosdeLEV Balónhidrostá(co TAN Suturashemostá(cas Monitoriainvasiva Transfusión Vasopresores Histerectomía Controldedaños Politransfusión Factorescoagulación 30minutos 30minutos
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