1. Healthcare

at the intersection of he alth, he alth c are, and polic y
February 2015 Vol. 34 No. 2 healthaffairs.org
Biomedical Innovation
from the editor-in-chief
198
220
The Promise Of Biomedical
Innovation
Alan R. Weil
entry point
199
Investor Drought And
Regulatory Headwinds Slow
Device Innovation
Sabin Russell
229
value of innovation
203
commentary Biomedical
Innovation In The Era Of Health
Care Spending Constraints
James C. Robinson
210
The Evolution Of Biotechnology
And Its Impact On Health Care
Ronald Evens and
Kenneth Kaitin
239
Robot-Assisted Surgery For
Kidney Cancer Increased Access
To A Procedure That Can Reduce
Mortality And Renal Failure
Amitabh Chandra,
Julia Thornton Snider,
Yanyu Wu, Anupam Jena,
and Dana P. Goldman
Treating Age-Related Macular
Degeneration: Comparing
The Use Of Two Drugs Among
Medicare And Veterans Affairs
Populations
Suzann Pershing,
Christine Pal Chee,
Steven M. Asch,
Laurence C. Baker,
Derek Boothroyd,
Todd H. Wagner, and
M. Kate Bundorf
economics of innovation
245
Decline In Economic Returns
From New Drugs Raises
Questions About Sustaining
Innovations
Ernst R. Berndt, Deanna Nass,
Michael Kleinrock, and
Murray Aitken
253
Medicare Is Scrutinizing
Evidence More Tightly
For National Coverage
Determinations
James D. Chambers,
Matthew Chenoweth,
Michael J. Cangelosi,
Junhee Pyo, Joshua T. Cohen,
and Peter J. Neumann
261
US Hospital Payment
Adjustments For Innovative
Technology Lag Behind Those
In Germany, France, And Japan
John Hernandez,
Susanne F. Machacz, and
James C. Robinson
commentary Creating Value
In Health By Understanding
And Overcoming Resistance To
De-Innovation
Peter A. Ubel and David A. Asch
Continued on page 194
Health Affairs is a multidisciplinary, peer-reviewed journal dedicated to the serious exploration of domestic and international health policy issues. Health Affairs (ISSN:
0278-2715, electronic ISSN: 1544-5208) is published monthly by Project HOPE, 7500 Old Georgetown Road, Suite 600, Bethesda, MD 20814-6133. ©2015 by Project
HOPE — The People-to-People Health Foundation, Inc. Periodicals-class postage paid at Bethesda, Maryland, and at additional mailing offices. online access Full online
archives of all papers published in Health Affairs since 1981 appear at www.healthaffairs.org. Web First papers appear online ahead of print. Health Affairs’ website is
produced in conjunction with Stanford University’s HighWire Press. postmaster Send Change of Address to Health Affairs, P.O. Box 148, Congers, NY 10920-1048.
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Continued from page 193
The Decline Of Venture Capital
Investment In Early-Stage
Life Sciences Poses A Challenge
To Continued Innovation
Jonathan J. Fleming
277
Repairing The Broken Market
For Antibiotic Innovation
Kevin Outterson,
John H. Powers,
Gregory W. Daniel, and
Mark B. McClellan
entry point
intellectual property &
innovation
286
294
302
194
Feb_TOC.indd 194
The Roles Of Academia, Rare
Diseases, And Repurposing
In The Development Of The
Most Transformative Drugs
Aaron S. Kesselheim,
Yongtian Tina Tan, and
Jerry Avorn
Biosimilar Competition In
The United States: Statutory
Incentives, Payers, And
Pharmacy Benefit Managers
Benjamin P. Falit,
Surya C. Singh, and
Troyen A. Brennan
The Roles Of Patents And
Research And Development
Incentives In Biopharmaceutical
Innovation
Henry G. Grabowski,
Joseph A. DiMasi, and
Genia Long
health affairs
328
Transcatheter Valve Therapy
Registry Is A Model For
Medical Device Innovation And
Surveillance
John D. Carroll, Jeff Shuren,
Tamara Syrek Jensen,
John Hernandez,
David Holmes,
Danica Marinac-Dabic,
Fred H. Edwards,
Bram D. Zuckerman,
Larry L. Wood,
Richard E. Kuntz, and
Michael J. Mack
web first
Money matters: Zach Zwirko at work in the
Cambridge, Massachusetts, lab of biomedical
company Foundation Medicine. Life sciences
firms that develop new and innovative medical
devices are finding it harder to attract
investments from venture capital firms.
tracking innovation
311
Case Studies On Forecasting
For Innovative Technologies:
Frequent Revisions Improve
Accuracy
Jeffrey C. Lerner,
Diane C. Robertson, and
Sara M. Goldstein
319
Improving Pharmaceutical
Innovation By Building A More
Comprehensive Database On
Drug Development And Use
Gregory W. Daniel, Alexis Cazé,
Morgan H. Romine,
Céline Audibert,
Jonathan S. Leff, and
Mark B. McClellan
february 2015
34:2
335
datawatch Medicare Per
Capita Spending By Age And
Service: New Data Highlights
Oldest Beneficiaries
Patricia Neuman,
Juliette Cubanski, and
Anthony Damico
340
Medicaid Expansion In
Opt-Out States Would Produce
Consumer Savings And
Less Financial Burden Than
Exchange Coverage
Steven C. Hill
Photograph by David L. Ryan/Boston Globe via Getty Images
271
Continued on page 195
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February 2015 Vol. 34 No. 2 healthaffairs.org
Continued from page 194
narrative matters
350
Navigating Veronika: How
Access, Knowledge, And
Attitudes Shaped My Sister’s
Care
Elizabeth Piatt
grantwatch
354
Funders’ Support For Palliative
And End-Of-Life Care
Lee L. Prina
health policy
briefs
357BookMarks
letters
359
Global HIV Funding And Local
Contexts
Mahesh Devnani,
Anil K. Gupta, and Yan Guo
359
Global HIV Funding: The Author
Replies
Victoria Y. Fan
359Errata
book reviews
356
357
Generic Drugs’ Uncommon
Story
Elizabeth Richardson
Microbes And Mystery
Sarah B. Dine
361
Instructions To Authors
Health Policy Briefs provide clear,
accessible overviews of timely
and important health policy
topics. The peer-reviewed briefs
explore competing arguments
and point out relevant research.
Health Policy Briefs are available
online and produced by Health
Affairs through a grant from the
Robert Wood Johnson Foundation.
Sign up for free policy briefs at
http://www.healthaffairs.org/
healthpolicybriefs.
The Family Glitch
November 10, 2014
The 340B Discount Program
November 17, 2014
Physician Compare
December 11, 2014
Illustration by Brett Ryder
Reenrollment
December 22, 2014
Narrative Matters When a tooth infection turns
into a health emergency, a woman helps her
sister get the care she needs.
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