WORKSHOPS “CURRENT TRENDS IN BIOMEDICINE” 2014 CAMPUS ANTONIO MACHADO BAEZA, SPAIN PROTEASES AT WORK: CUES FOR UNDERSTANDING NEURAL DEVELOPMENT AND NEURODEGENERATION Baeza, Spain • 20th-22nd October 2014 Organized by: Paola Bovolenta Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM. Madrid, Spain. Paul Saftig Institut für Biochemie, ChristianAlbrechts-Universität zu Kiel. Kiel, Germany. SCOPE Proteolytical processing of membrane bound molecules is emerging as a fundamental mechanism for controlling the strength and timing of cell-tocell communication, which is at the basis of tissue development and homeostasis. This process acquires particular importance in the context of the brain because its function strongly depends on well-orchestrated interactions among many different cell types. Members of families of metalloproteinases are major effectors of these events. Understanding how proteinases, particularly metalloproteinases, coordinate brain development or how they contribute to brain pathologies when disregulated, requires multi-disciplinary approaches tackling the problem from different perspectives. This workshop will summarize the most recent biochemical and genetic evidence demonstrating that proteases are required for development, function and homeostasis of the CNS, underscoring their relevance in neurodegeneration and discussing whether endogenous or pharmacological modulation of their activity represents a therapeutic tool to prevent synaptic loss, neural defects or brain diseases. FORMAT OF THE WORKSHOP The workshop will bring together 15 speakers and a maximum of 33-35 participants, to form a group of around 50 people. The scientific programme will start in the morning of Monday, October 20th, and will end around noon on Wednesday, October 22nd. Ample time for informal discussion will be reserved. Participants will be invited to present a poster. VENUE OF THE WORKSHOP The workshop will be held in Baeza, at the “Campus Antonio Machado”, a XVII century building turned into a Conference Centre of the Universidad Internacional de Andalucía (UNIA). This Seat includes a recently restored residence, where participants will be accommodated. Baeza is a World Historic Heritage town, renowned for its Renaissance and Gothic buildings. SPEAKERS Carl P. Blobel Arthritis and Tissue Degeneration Program, Hospital for Special Surgery / Departments of Medicine and of Physiology, Biophysics and Systems Biology, Weill Medical College of Cornell University. New York, NY, USA. Paola Bovolenta Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM / CIBER de Enfermedades Raras (CIBERER). Madrid, Spain. Elena Cattaneo Department of Biosciences and Center for Stem Cell Research, Università degli Studi di Milano. Milan, Italy. Bart De Strooper KU Leuven Center for Human Genetics and Leuven research Institute for Neuroscience and Disease (LIND) / VIB Center for the Biology of Disease. Leuven, Belgium. Kristina Endres Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz. Mainz, Germany. Pilar Esteve Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM / CIBER de Enfermedades Raras (CIBERER). Madrid, Spain. Isabel Fariñas Departamento de Biología Celular, Universidad de Valencia / Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). Valencia, Spain. Nigel M. Hooper Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester. Manchester, UK. Leszek Kaczmarek Department of Molecular and Cellular Neurobiology, The Nencki Institute of Experimental Biology. Warsaw, Poland. Patricia F. Maness Department of Biochemistry and Biophysics, University of North Carolina School of Medicine. Chapel Hill, NC, USA. Lieve Moons Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven. Leuven, Belgium. Paul Saftig Institut für Biochemie, Christian-AlbrechtsUniversität zu Kiel. Kiel, Germany. Shanthini Sockanathan The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine. Baltimore, MD, USA. Taisuke Tomita Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo. Tokyo, Japan. Avraham Yaron Department of Biological Chemistry, Weizmann Institute of Science. Rehovot, Israel. DEADLINE: 5th SEPTEMBER 2014 MORE INFORMATION AND APPLICATION: http://www.unia.es/biomedicine Universidad Internacional de Andalucía Campus Antonio Machado Palacio de Jabalquinto Plaza de Santa Cruz, s/n. 23440 Baeza (Jaén), Spain Tel: +34 953 74 27 75. Fax: +34 953 74 29 75. E-mail: [email protected]
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