1. No category

RESUMENES DE LAS COMUNICACIONES
LVIII ANNUAL MEETING
Argentine Society for Clinical Investigation
2013 MEETING
Argentine Physiological Society
XLV ANNUAL MEETING
Argentine Society of Experimental Pharmacology
November 20-23, 2013
Hotel 13 de Julio – Mar del Plata – Buenos Aires- Argentina
I
Dear Friends and Colleagues,
It is our pleasure to welcome you to the LVIII Scientific Meeting of the Argentine Society for
Clinical Investigation (SAIC) to be held jointly with the Annual Meeting of the Argentine Physiological Society (SAFIS) and the XLV Meeting of the Argentine Society of Experimental Pharmacology
(SAFE) in the city of Mar del Plata, Argentina, from 20th to 23rd November 2013. The Meeting has been designed to provide an innovative and comprehensive overview of the
latest research developments in Neurosciences, Nephrology, Gastroenterology, Oncology, Cardiovascular, Endocrinology, Hematology, Reproduction, Regenerative Medicine, Genetics, Signal
Transduction and Pharmacology, among other disciplines. Highly distinguished international and
local speakers from different scientific areas will participate in conferences and symposia on cutting edge topics. One of the main goals of this year is to highlight Poster Sessions in order to
encourage a rich scientific interaction among all participants, so no other activities will occur at
the same time. The program will also feature diverse short courses on hot topics, meetings with
experts as well as a science policy workshop with local authorities of Science and Technology
and representatives of the main biomedical societies of Argentina. Your active participation in the Meeting through the presentation of your work on any of the
thematic topics reflects our wishes. Your submissions will be most welcome and your particular
contributions highly appreciated.
We hope that you will enjoy the Meeting and that your interaction with your colleagues around
the world will stimulate a creative exchange of ideas, contribute to find international partnerships
for future academic and scientific collaboration and be personally rewarding. We also hope and
trust that you will enjoy your visit to the very beautiful and exciting city of Mar del Plata, Argentina.
SAIC, SAFIS and SAFE
PARTICIPATING SOCIETIES
BOARDS
SAIC
President
Carlos A. Davio
SAFIS
President
Claudia Capurro
SAFE
President
Damasia Becu-Villalobos
Vicepresident
Héctor Targovnik
Vicepresident
Alejandro Aiello
Vicepresident
Nora Brandán
Secretary General
Liliana G. Bianciotti
Secretary General Paula Ford Secretary General
Paula Schaiquevich
Treasurer
Carina Shayo
Treasurer
María de los Ángeles Costa
Treasurer
Victoria Lux Lantos
Pro-secretary
María Cecilia Carreras
Members
Pablo Arzumendi
Marina Barbich
Bruno Buchholtz
Ana María Cabanillas
Stella Campo
Rodolfo Goya
Enrique Luque
Gabriela Meresman
Martín Monte
María Giselle Peters
Andrea Randi
Ruth Rosenstein
Nora Saraco
Members
Gustavo Pérez
Viviana Catania
Cristina Arranz
Valera Rivarola
Sara Molinas
Laura Vivas
María Peral de Bruno
Marta Roque
Roberto Malinow
Guillermo Lehmann
Members
Sergio SanchezBruni
Carlos Reyes Toso
Silvia Wikinski
Auditors
Mariana Farina
Adalí Pecci
Auditors
Susana Mosca
Graciela Cremaschi
Auditors
Héctor Alejandro Serra
Marcela Rebuelto
Adriana Torres (substitute)
Miriam Wald (substitute)
ISSN 0025-7680
1
SAIC-SAFIS-SAFE 2013 PROGRAM
MEDICINA (Buenos Aires) 2013; 73 (Supl. III): 1-7
PROGRAM
WEDNESDAY 20th NOVEMBER
8:00 AM -06:00 PM - REGISTRATION
Selected short talk:
9:00 AM-10:30 AM - HANGING UP POSTERS
3:45 PM-4:00 PM – Role of Galectin 7 (GAL-7) in Langerhans Cells
Pysiology and Tolerogenic Circuits formation in the Skin.
Pinto N.; Méndez Huergo S.; Dalotto Moreno T.; Salatino M.;
Rabinovich G.; Cerliani J.
10:30 AM -12:30 PM - POSTERS PRESENTATION
DisciplineRoom
Endocrinology 1
Lobby
Reproduction 1
Mediterráneo
Infectious Diseases, Inflammation & Immunology 1
Muelle Azul
Metabolism & Nutrition 1
Muelle Azul
Oncology 1
Muelle Azul
Signal Transduction 1
Muelle Azul
Cardiovascular 1
Aguamarina
Gastroenterology 1
Aguamarina
Genetics 1
Aguamarina
Hematology 1
Aguamarina
Nephrology 1
Aguamarina
Regenerative Medicine & Cellular Therapy 1
Aguamarina
Cellular Physiology 1
Aguamarina
Neuroscience 1
Acuario
Pharmacokinetics 1
Acuario
Pharmacodynamics 1
Acuario
Pharmacognosy 1
Acuario
Pharmacoepidemiology 1
Acuario
Molecular Pharmacology 1
Acuario
Clinical Pharmacology 1
Acuario
Pharmacotherapeutics 1
Acuario
Toxicology 1
Acuario
2:00 PM-4:00 PM - SYMPOSIA
Coral Room
2:00 PM-2:35 PM - GUSTAVO ABRAHAM. Instituto de Investigaciones
en Ciencia y Tecnología de Materiales, INTEMA-CONICET,
Universidad Nacional de Mar del Plata, ARGENTINA.
“Available Biomaterials and Technologies in
Matrix Production for Skin Regeneration”
2:35 PM-3:10 PM - GUSTAVO LEIROS. Instituto de Ciencia y Tecnología Dr. César Milstein- CONICET, Fundación Pablo Cassará, ARGENTINA.
“Generation of Complex Tissue Substitutes for
Deep Wound Therapeutics”
3.10 PM-3:45 PM - HUGO DRAGO. Hospital Municipal del Quemado,
Buenos Aires, ARGENTINA.
Topacio Room
2:00 PM-2:35 PM - GUILLERMO CHANTADA. Hospital de Pediatría
“Profesor Dr. Juan P. Garrahan”, ARGENTINA.
“Pediatric Clinical Pharmacological Studies Applied to Retinoblastoma”
2:35 PM-3:10 PM - MARIANO GABRI. Laboratorio de Oncología
Molecular, Universidad Nacional de Quilmes, ARGENTINA.
“Potential Tumoral Markers in the Treatment and
Diagnosis of Pediatric Cancer”
3:10 PM-3:45 PM - PAULA SCHAIQUEVICH. Unidad de Farmacocinética Clínica, Hospital de Pediatría “Profesor Dr. Juan P.
Garrahan”, ARGENTINA.
“Translational Studies on Retinoblastoma: The
Argentine Experience”
Selected short talk:
3:45 PM-4:00 PM - Azoxymethane Induces Neoplastic Processes
in Zebrafish (DANIO RERIO). Barrio D.
Symposium 3: REPRODUCTIVE PATHOLOGY: FROM
THE LAB TO THE CLINICS.
Chaired: Ana Franchi and Gabriela Meresman
Symposium 1- INTELLIGENT MATRICES IN SKIN
WOUND REPAIR.
Chaired: Alejandro Serra
Atlantic Room
2:00 PM-2:35 PM - MARGARITA VEGA. Departamento de Obstetricia
y Ginecología, Facultad de Medicina, Hospital Clínico, Universidad de Chile, CHILE.
12.30 PM-2.00 PM - LUNCH
Chaired: Mariana Barbich
Symposium 2: PHARMACOLOGICAL STUDIES ON
PEDIATRIC ONCOLOGY.
“Clinical Application of Matrices in Wound Repair”
“Molecular Changes in the Endometrium of Women with Polycystic Ovary Syndrome and their
Significance in Reproduction”
2:35 PM-3:10 PM - ALICIA JAWERBAUM. Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET). Facultad de
Medicina, Universidad de Buenos Aires, ARGENTINA.
“Activity of Nuclear Receptors in Diabetes-complicated Pregnancy”
3:10 PM-3:45 PM - GUSTAVO LEGUIZAMÓN. Centro de Educación
Médica e Investigaciones Clínicas (CEMIC), ARGENTINA.
“Diabetes and Pregnancy”
Selected short talks:
3:45 PM-4:00 PM - Galectin-1 Plays an Essential Pro-angiogenic
Role by Inducing Vascularization and Growth of Endometriosic Lesions in an Experimental Murine Model. Baston,
J.; Barañao, R.; Ricci, A.; Bilotas, M.; Olivares, C.; Croci, D.;
Rabinovich, G.; Meresman, G.
2
MEDICINA - Volumen 73 - (Supl. III), 2013
4:00-4:15 - PDGF System Involvement in the Ovarian Hyperstimulation Syndrome (OHS): ¿A Potential Therapeutic
Strategy? Pascuali N.; Scotti L.; Abramovich D.; Tesone
M.; Parborell F.
5:30 PM-6:30 PM - SAIC OPENING LECTURE
Atlantic Room
Chaired: Carlos Pirola
– JEFFREY FRIEDMAN. Laboratory of Molecular Genetics, Rockefeller
University, USA.
CARLOS A. DAVIO
President of the Argentine Society for Clinical Investigation
DAMASIA BECU-VILLALOBOS
President of the Argentine Society of Experimental Pharmacology
CLAUDIA CAPURRO
President of the Argentine Physiological Society
“Leptin and the Biologic Basis of Obesity”
8:00 PM-8:30 PM - POSTERS REMOVAL
7:00 PM-8:00 PM - WELCOME ADDRESSES FROM
THE PRESIDENTS OF THE PARTICIPATING SOCIETIES
Atlantic Room
9:30 PM - WELCOME COCKTAIL
Hotel UTHGRA PRESIDENTE PERÓN
Address: Tucumán 2662, Mar del Plata.
THURSDAY 21st NOVEMBER
8:00 AM-6:00 PM - REGISTRATION
8:00 AM-9:00 AM - HANGING UP POSTERS
10:30 AM-11:00 AM - MARIELA PÉREZ. Instituto de Farmacología
Experimental de Córdoba, Facultad de Ciencias Químicas,
Universidad Nacional de Córdoba, ARGENTINA.
8:00 AM-9:00 AM - SHORT COURSES
“Does Sildenafil Increase the Vulnerability to
Psychotropic Drug Abuse?: An Experimental
Evidence”
– “Translational Bioinformatics: From Genomics to Personalized
Medicine”. Marcelo Martí
Atlantic Room
Laboratorio Interdisciplinario de Bioquímica Estructural, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales,
Universidad de Buenos Aires.
–“Experimental Methods Applied to the Study of Xenobiotic
Transport and Metabolism”
Guillermo Virkel Topacio Room
Centro de Investigación Veterinaria Tandil (CIVETAN-CONICET),
Facultad de Ciencias Veterinarias (UNCPBA), Tandil, Buenos Aires.
– “Anesthesia, Analgesy and Euthanasia in Laboratory Animals”
Andrea Zaccagnini
Coral Room
Cátedra de Anestesiología y Algiología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires.
Symposium 5: IONIC TRANSPORT IN CARDIOVASCULAR PATHOPHYSIOLOGY (SAFIS).
9:00 AM-11:00 AM-SYMPOSIA
Symposium 4: SAIC YOUNG INVESTIGATOR SYMPOSIUM.
Chaired: María Giselle Peters and Ana María Cabanillas
Atlantic Room
9:00 AM-9:30 AM - MARIANELA CANDOLFI. Instituto de Investigaciones Biomédicas INBIOMED, Facultad de Medicina, Universidad
de Buenos Aires, ARGENTINA
“Gene Therapy Strategies for the Treatment of
Brain Cancer”
9:30 AM-10:00 AM - CAROLINA CRISTINA. Centro de BioInvestigaciones (CeBio), Universidad Nacional del Noroeste de Buenos
Aires, ARGENTINA.
“Cancer Stem Cells as Therapeutic Targets in
Pituitary Adenomas? Wnt/β-Catenina and Notch
Signalling Pathways
10:00 AM-10:30 AM - VANINA MEDINA. Laboratorio de Radioisótopos,
Facultad de Farmacia y Bioquímica, Universidad de Buenos
Aires, ARGENTINA.
“H4 Histamine Receptor Ligands as Potential Pharmacological Tools to Improve Cancer Therapy”
Chaired: Alejandro Aiello
Topacio Room
9:00 AM-9:35 AM - JOSEPH CASEY. Department of Biochemistry,
School of Translational Medicine, Faculty of Medicine & Dentistry, University of Alberta, CANADA.
“Carbonic Anhydrases and Bicarbonate Transporters in Heart Failure”
9:35 AM-10:10 AM - BERNARDO ÁLVAREZ. Facultad de Ciencias
Médicas, Universidad Nacional de La Plata, ARGENTINA.
“Carbonic Anhydrase Inhibitors and Pro-hypertrophic Signals Mediated by Heart Muscle Stretch”
10:10 AM-10:45 AM - VERÓNICA MILESI. Grupo de Investigación
en Fisiología Vascular (GINFIV), Universidad Nacional de La
Plata, ARGENTINA.
“Arachidonic Acid and its Metabolites on Cardiovascular Health: Effects on K+ Channels in
Vascular Smooth Muscle”
Selected short talk:
10.45 AM-11.00 AM – “Potassium Channel Regulation in Hypertension: Role of Natriuretic Peptide Type C”. Caniffi C.; Sueiro
L.; Muñoz González F.; Arranz C.; Costa M.
Symposium 6: STEM CELLS AND REGENERATIVE
MEDICINE (SAIC).
Chaired: Rodolfo Goya
Coral Room
9:00 AM-9:35 AM - ALBERTO CROTTOGINI. Universidad Favaloro,
ARGENTINA.
“Genetically Modified Mesenchymal Cells in an
Ovine Model of Heart Attack”
9:35 AM-10:10 AM - GUILLERMO MAZZOLINI. Laboratorio de Terapia
Génica, Facultad de Ciencias Biomédicas, Universidad Austral,
ARGENTINA.
“Use of Mesenchymal Cells as Therapeutic Tools
in Cirrhosis and Hepatocarcinoma”
3
SAIC-SAFIS-SAFE 2013 PROGRAM
10:10 AM-10:45 AM - RICARDO DEWEY. Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús
(IIB-INTECH-CONICET), Universidad Nacional de San Martín,
ARGENTINA.
“The Microenvironment of Stem Cells and Regenerative Medicine”
Selected short talk:
10:45 AM-11:00 AM – “Role of Protein Arginine Methyltransferase
8 (PRMT8) in Stem Cells”. Luzzani C.; Solari C.; Waisman A.;
Losino N.; Sevlever G.; Barañao L.; Miriuka S.; Guberman A.
11:30 AM-12:30 PM - CONFERENCES
SAIC CONFERENCE
Chaired: Liliana G. Bianciotti
Topacio Room
“Signaling Pathways Regulating Exocrine Pancreatic
Function and Disease”
Chaired: Cristina Ibarra
3:45 PM-4:00 PM – “EGF Increases cAMP Levels in Murine Breast
Epithelial Cells. Role of CREB Protein in BCL-XL Expression”. Grinman D.; Romorini L.; Davio C.; Pecci A.
Symposium 8: NEW ASPECTS IN THE REGULATION
OF THE CARDIOVASCULAR AND RENAL FUNCTION
(SAIC).
Chaired: Marcelo S. Vatta
Coral Room
Topacio Room
2:00 PM-2:35 PM - JAVIER STERN. Department of Physiology,
Medical College of Georgia, Georgia Regents University, USA.
–JOHN A. WILLIAMS. Department of Molecular and Integrative
Physiology, University of Michigan, USA.
SAFIS CONFERENCE
Selected short talk:
“Novel Insights into the Regulation of Cardiovascular and Renal Function”
2:35 PM-3:10 PM - VAGNER ANTUNES. Instituto de Ciências Biomédicas (ICB-I) da Universidade de São Paulo, BRAZIL.
“Hypothalamic-Brainstem Circuitry as the Coordinator of Autonomic Functions at Different
Adaptive and Pathophysiological States”
3:10 PM-3:45 PM - FERNANDO IBARRA. Instituto de Investigaciones
Médicas Alfredo Lanari
������������������������������������������
(IDIM-CONICET). �������������������
Departamento de Fisiología y Biofísica, Unidad Académica 1, Facultad de Medicina,
Universidad de Buenos Aires, ARGENTINA.
“Ovariectomy: Effects on Renal Function, Sodium
Excretion and Blood Pressure Regulation”
–MOHAMED KARMALI. Department of Pathology and Molecular
Medicine, Mc Master University, Laboratory for Food-borne Zoonoses, Public Health Agency of Canada, Ontario, CANADA.
Selected short talk:
SAIC CONFERENCE
3:45 PM-4:00 PM - “Arterial Stiffness Index in a Population of
Buenos Aires, Argentina and the Isolated Impact Analysis
of Arterial Hypertension. Díaz A.; Cabrera Fischer E.; Galli
C.; Ramírez A.
“Hemolytic Uremic Syndrome: The Continuing Evolution of a Bacteria”
Chaired: Graciela Scharovsky
Atlantic Room
–NICOLAS ANDRÉ. Hématologie & Oncologie Pédiatrique, Hôpital
pour enfants de “la Timone”, AP-HM, Marseille, FRANCE.
“Metronomics: Combining Scientific, Medical and
Social Innovation”
12:30 PM-2:00 - PM LUNCH
2:00 PM-4:00 PM SYMPOSIA
Symposium 7: BIASED AGONISM IN G PROTEIN-COUPLED RECEPTORS: FROM STRUCTURAL BIOLOGY TO
CLINICALLY RELEVANT ASPECTS (SAIC-SAFE JOINT
SYMPOSIUM).
Atlantic Room
2:00 PM-2:35 PM - ANDRÉ SAMPAIO PUPO. Instituto de Biociências,
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP,
Botucatu), BRAZIL.
“Biased Agonism for Phenethylamine and Imidazoline Ligands in alpha-1 Adrenoceptor Subtypes”
2:35 PM-3:10 PM - XAVIER DEUPI. Condensed Matter Theory Group
and Laboratory of Biomolecular Research, Paul Scherrer Institut
(PSI), Villigen, SWITZERLAND.
“Structural Aspects in G Protein-coupled Receptor Activation”
3:10 PM-3:45 PM - NATALIA FERNÁNDEZ. Cátedra de Química
Medicinal, Facultad de Farmacia y Bioquímica, Universidad de
Buenos Aires, ARGENTINA.
Chaired: Marta Tesone
“Biased Inversed Agonism at Histamine H2 Receptors”
Coral Room
2:00 PM-2:35 PM - GRACIELA CREMASCHI. Instituto de Investigaciones Biomédicas (BIOMED-CONICET), Universidad Católica,
Buenos Aires, ARGENTINA.
12:45 PM -1:45 PM – Commercial Symposium - ROCHE
LABORATORY
- PATRICIA PICARDO
Topacio Room
“Launching LightCycler 96: “Super capabilities within
your lab reach”
Chaired: Federico Monczor
Symposium 9: ADVANCES IN ENDOCRINOLOY (SAIC).
“Genomic and Non-genomic Mechanisms Involved in the Regulation of Lymphocyte Function
by Thyroid Hormones”
2:35 PM-3:10 PM - RODOLFO REY. Instituto de Investigaciones Endocrinológicas Dr. César Bergadá (CEDIE-CONICET) División
de Endocrinología, Hospital de Niños Ricardo Gutiérrez, FEICONICET, ARGENTINA.
“AMH: The Fetal Testicular Hormone that Better
Reflects Ovary Follicular Reserve”
3:10 PM-3:45 PM - GRACIELA DIAZ. Instituto de Biología y Medicina
Experimental (IBYME-CONICET), ARGENTINA.
“The Complex TGFbeta 1 System in Normal and
Tumoral Hypophyses”
Selected short talk:
3:45 PM-4:00 PM – “CRH Signals through Different cAMP Sources
in Hippocampal Neurons”. Inda C.; Bonfiglio J.; Senin S.;
Atorresi A.; González H.; Holsboer F.; Arzt E.; Silberstein S.
4:30 PM -5:30 PM - CONFERENCES
“ALBERTO TAQUINI” PLENARY LECTURE (SAIC).
Chaired: Viviana Catania
Atlantic Room
– ALDO MOTTINO. Instituto de Fisiología Experimental (IFISE-CONICET), Facultad de Ciencias Bioquímica y Farmacéuticas, Universidad
Nacional de Rosario, ARGENTINA.
“Multidrug Resistance Associated Protein 2 as a
Barrier to Xenobiotic Intestinal Absorption: Hormonal
Modulation”
4
MEDICINA - Volumen 73 - (Supl. III), 2013
SAFE CONFERENCE
Chaired: Cristina Ibarra
Topacio Room
–JAVIER ARIAS VALLEJO. G.I.R. BIOFORGE, Ciber BBN Centro
de I+D, Universidad de Valladolid, SPAIN.
"Therapeutic Nano-devices from Multifunctional Recombinant Polimers"
6:00 PM-8:00 PM – POSTERS PRESENTATION
DisciplineRoom
Endocrinology 2
Lobby
Reproduction 2
Mediterráneo
Infectious Diseases, Inflammation & Immunology 2
Muelle Azul
Metabolism & Nutrition 2
Muelle Azul
Oncology 2
Muelle Azul
Signal Transduction 2
Muelle Azul
Cardiovascular 2
Aguamarina
Gastroenterology 2
Aguamarina
Genetics 2
Aguamarina
Hematology 2
Aguamarina
Nephrology 2
Aguamarina
Regenerative Medicine & Cellular Therapy 2 Aguamarina
Cellular Physiology 2
Aguamarina
Neuroscience 2
Acuario
Pharmacokinetics 2
Acuario
Pharmacodynamics 2Acuario
Pharmacognosy 2
Acuario
Pharamcoepidemiology 2
Acuario
Molecular Pharmacology 2
Acuario
Clinical Pharmacology 2
Acuario
Pharmacotherapeutics 2
Acuario
Toxicology 2
Acuario
8:00 PM-8:30 PM - POSTERS REMOVAL
8:30 PM - SAFE ANNUAL GENERAL ASSEMBLY
Atlantic Room
8:30 PM - SAFIS ANNUAL GENERAL ASSEMBLY
Topacio Room
FRIDAY 22nd NOVEMBER
8:00 AM-6:00 PM - REGISTRATION
Selected short talk:
8:00 AM-9:00 AM - HANGING UP POSTERS
10:45 PM-11:00 PM – “Ex vivo Adipogenic Delay is Glucocorticoiddependent in a Hypothalamic Obesity Model”. Zubiría M.;
Castrogiovanni D.; Spinedi E.; Giovambattista A.
8:00 AM-9:00 AM - SHORT COURSES
– “Informed Consent”
Carlos Burger
Atlantic Room
Hospital Italiano de Buenos Aires.
– “Non Lineal Microscopy Applied to Clinical Studies”
Javier Adur
Topacio Room
Laboratorio de Microscopía Aplicada a Estudios Celulares y Moleculares, Cátedra Radiaciones No Ionizantes, Facultad de Ingeniería,
Universidad Nacional de Entre Ríos.
– “Anlysis and Interpretation of Protein Structures”
Diego Ferreiro
Coral Room
Laboratorio de Fisiología de Proteínas, Departamento de Química
Biológica, Facultad de Ciencias Exactas y Naturales, Universidad
de Buenos Aires.
Symposium 11: HEMATOLOGICAL DISORDERS: DIAGNOSTIC AND FUTURE THERAPEUTIC PERSPECTIVES
(SAIC).
Chaired: Irma Slavutsky
Topacio Room
9:00 AM-9:35 AM - LUCIO CASTILLA. Program in Molecular Medicine,
University of Massachusetts Medical School, USA.
“Targeted Therapies for inv16 Acute Myeloid
Leukemia”
9:35 AM-10:10 AM - CARLOS DE BRASI. Instituto de Medicina Experimental (IMEX-CONICET), Academia Nacional de Medicina,
ARGENTINA.
9:00 AM-11:00 AM - SYMPOSIA
“Lessons from Human Hemophilia: Big Inversions and Rearrangements Caused by Homologous Recombination in X Chromosome”
Symposium 10: THE METABOLIC SYNDROME: THE
GREAT MEDICAL PROBLEM OF THE CENTURY (SAIC).
10:10 AM-10:45 AM - PAULA HELLER. Instituto de Investigaciones
Médicas Alfredo Lanari (IDIM-CONICET), Facultad de Medicina,
Universidad de Buenos Aires, ARGENTINA.
9:00 AM-9:35 AM - CARLOS PIROLA. Departamento de Biología
Molecular y Genética de Enfermedades Complejas, Instituto
de Investigaciones Médicas Alfredo Lanari (IDIM-CONICET),
Universidad de Buenos Aires, ARGENTINA.
Selected short talk:
Chaired: Silvia Sookoian
Atlantic Room
10:45 AM-11:00 AM – “Acute Lymphoblastic Leukemia in Pediatrics: Glutation-S-transferases Genotype may Help to
Identify Patients at High Risk of Relapse”. Cotignola J.;
Leonardi D.; Núñez M.; De Siervi A.; Alfonso G.; Riccheri
M.; Vázquez E.
“Obesogens, Stem Cells and the Transgenerational Programming of Obesity”
11:30 AM-12:30 PM - CONFERENCES
10:10 AM-10:45 AM - DARIO RAMÍREZ. Instituto Multidisciplinario de
Investigaciones Biológicas de San Luis (IMIBIO-SL-CONICET),
Universidad Nacional de San Luis, ARGENTINA.
“New Perspectives on Platelet Production from
Studies on Thrombocytopenia”
“Factors in the Fetal Programming as the Origin
of Diseases in Adulthood”
9:35 AM-10:10 AM - BRUCE BLUMBERG. Departments of Developmental and Cell Biology and Pharmaceutical Sciences, University of California, Irvine, California, USA.
“Role of Myeloperoxidase in the Metabolic Abnormalities Associated to Obesity”
SAIC CONFERENCE
Chaired: Gabriel Rabinovich
Atlantic Room
– FRANCISCO QUINTANA. Center for Neurologic Diseases, Brigham
and Women’s Hospital, Harvard Medical School, Boston, USA.
5
SAIC-SAFIS-SAFE 2013 PROGRAM
“Molecular Mechanisms Involved in the Regulation
of Neuroinflammation”
SAFIS CONFERENCIA
Chaired: Laura Vivas
Topacio Room
– JOSEPH VERBALIS. Georgetown University Medical Center, Washington, USA.
“Neuroendocrine Involvement in Disorders of Fluid
and Electrolyte Balance”
12:30 PM-2:00 PM - LUNCH
2:00 PM-4:00 PM - SYMPOSIA
Symposium 12: FUTURE CHALLENGES IN BASIS AND
CLINICAL RESEARCH IN VIROLOGY: IS IT POSSIBLE
TO ERADICATE HIV and DENGUE VIRUSES? (SAIC).
Chaired: Horacio Salomón
Topacio Room
2:00 PM-2:20 PM – “Heme oxigenase-1 (HO-1): A new cellular
rheostat in prostate cancer”. Geraldine Gueron; Jimena Giudice; Belén Elguero; Alejandra Páez; Martin Toscani; Federico
Coluccio Leskow; Pía Valacco; Elba Vázquez.
2:20 PM-2:40 PM – “Rational design of new GTPase RAC1 inhibitors with antimetastatic activity in breast cancer”. Pablo
Lorenzano Menna; Georgina A. Cardama; Nazareno González;
María J. Comin; Adrián Turjanski; Daniel F. Alonso; Daniel E.
Gómez.
2:40 PM-3:00 PM – “CTBP1 is a molecular metabolic sensor that
mediates prostate cancer development dependent on a rich
fat diet”. Cristian Moiola; Paola De Luca; Florencia Zalazar;
Javier Cotignola; Roberto Meiss; Pablo Vallecorsa; Osvaldo
Mazza; Carlos Scorticati; Dante Paz; Omar Pignataro; Elba
Vazquez; Adriana De Siervi.
3:00 PM-4:00 PM – SHORT TALKS: ADVANCES IN
ONCOLOGY (SAIC).
Chaired: Cristina Carrillo and Mónica Costas.
4:00 PM-4:15 PM - “Intestinal Permeation of a New Acid Derivative
of Zidovudin”. Schenfeld E.; Ribone S.; Briñón M.; Quevedo M.
3:00 PM-3:15 PM – “Genomic study of the specific cellular response in endometrial Ishikawa cells and T47D breast
cancer cells”. La Greca, Alejandro; Soronellas, Daniel; Vallejo,
Griselda; Merino, Gabriela; Fresno, Cristobal; Vicent, Guillermo;
Fernández, Elmer; Beato, Miguel; Saragüeta, Patricia.
3:15 PM-3:30 PM – “Personalized medicine in patients with ovarian cancer”. Loresto, María; González, Pamela; Kato, Sumie;
Braes, Jorge; Barriga, María Isabel; Bustamante, Eva; Alonso,
Catalina; Bravo, Erasmo; Arab, Clemente; Barrena, Nicanor;
Ibáñez, Carolina; Jiménez, Paula; Barra, Alejandro; Cuello,
Mauricio; Owen, Gareth.
3:30 PM-3:45 PM – “Role of P300 in cell lines and triple negative breast cancer human biopsies”. Fermento, María
E ; Gandini, Norberto A ; Salomón, Débora G ; Gonzalez
Donna, Lucila; Ferro, Alejandro; Facchinetti, María M; Curino, Alejandro C.
3:45 PM-4:00 PM – “Protein kinase CK2 inhibition by CIGB-300
affects tridimensional growth and WNT dependent signaling
pathway in human lung cancer cells”. Cirigliano, Stéfano;
Díaz Bessone, María Inés; Flumian, Carolina; Berardi, Damián
Emilio; Bal De KierJoffé, Elisa; Farina, Hernán; Todaro, Laura;
Urtreger, Alejandro.
Symposium 13: NEUROPHARMACOLOGY (SAFE).
4:30 PM-5:30 PM - CONFERENCES
2:00 PM-2:30 PM - PEDRO CAHN. Fundación Huésped, ARGENTINA.
“HIV: Towards the Epidemic Control”
“Basic Aspects in the Molecular Biology of Dengue Virus: Advances and Challenges”
2:30 PM-3:00 PM - ANDREA GAMARNIK. Fundación Instituto Leloir,
ARGENTINA.
3:00 PM-3:30 PM - DELIA ENRIA. Instituto Nacional de Enfermedades Virales Humanas “Dr. Julio I. Maiztegui” Pergamino,
ARGENTINA.
“Is Dengue Infection no Longer a Zoonosis?”
“The Immune Response in the Control of HIV
Infection: Therapeutic Perspectives”
3:30 PM-4:00 PM - JORGE GEFFNER. Facultad de Medicina, Universidad de Buenos Aires, ARGENTINA.
Selected short talk:
Chaired: Silvia Wikinski
Coral Room
2:00 PM-2:35 PM - FACUNDO MANES. Instituto de Neurociencias,
Universidad Favaloro, ARGENTINA.
Atlantic Room
–CLAUDIA LANARI. Instituto de Biología y Medicina Experimental
(IBYME-CONICET), ARGENTINA
“New Signaling Pathways in Levodopa-induced
Dyskinesias”
SAFE CONFERENCE
3:10 PM-3:45 PM - JUAN E. BELFORTE. Laboratorio de Fisiología
de la Conducta Animal, Grupo de Neurociencia de Sistemas,
Departamento de Fisiología, Facultad de Medicina, Universidad
de Buenos Aires, ARGENTINA.
Chaired: Edith Kordon
“New Therapeutic Targets in Alzheimer Disease
and Fronto-temporal Dementia”
2:35 PM-3:10 PM - JUAN FERRARIO. Instituto de Investigaciones
Farmacológicas (ININFA-CONICET), Facultad de Farmacia y
Bioquímica, Universidad de Buenos Aires, ARGENTINA.
“ALFREDO LANARI” PLENARY LECTURE (SAIC).
“Pathophysiology of Schizophrenia: Where Dopaminergic and Glutamatergic Theories Meet”
Selected short talk:
3:45 PM-4:00 PM – “GABAB receptors in the biochemical alterations induced by nicotine anxiolytic and anxiogenic doses
in mice: A pharmacological and genetic approach”. Varani
A.; Pedrón V.; Bettler B.; Balerio G.
2:00 PM-3:00 PM - MONTUORI FUNDACIÓN-GADOR AWARD (SAIC).
Atlantic Room
Award Committee: Reinaldo Chacón, Erick Ruuth, Alfredo Molinolo,
Mónica Costas and Cristina Carrillo.
“From Serendipity to a Clinically Applied Project in
Breast Cancer”
Chaired: Nora Brandan
Topacio Room
– WALDO BELLOSO. Sección Farmacología Clínica y Departamento
de Farmacología y Toxicología del Instituto Universitario Escuela de
Medicina, Hospital Italiano de Buenos Aires, ARGENTINA.
“The Pharmacogenomic Basis of Therapeutics”
6:00 PM-8:00 PM – POSTERS PRESENTATION
DisciplineRoom
Endocrinology 3
Lobby
Reproduction 3
Mediterráneo
Infectious Diseases, Inflammation & Immunology 3
Muelle Azul
Metabolism & Nutrition 3
Muelle Azul
Oncology 3
Muelle Azul
Signal Transduction 3
Muelle Azul
Cardiovascular 3
Aguamarina
6
MEDICINA - Volumen 73 - (Supl. III), 2013
Aguamarina
Aguamarina
Aguamarina
Aguamarina
Acuario
Acuario
Acuario
Acuario
Gastroenterology 3
Genetics 3
Nephrology 3
Cellular Physiology 3
Neuroscience 3
Pharmacokinetics 3
Pharmacodynamics 3
Pharmacolepidemiology 3
Acuario
Acuario
Acuario
Acuario
Molecular Pharmacology 3
Clinical Pharmacology 3
Pharmacotherapeutics 3
Toxicology 3
8:00 PM-8:30 PM - POSTERS REMOVAL
8:30 PM - SAIC ANNUAL GENERAL ASSEMBLY
SATURDAY 23rd NOVEMBER
8:00 AM-9:00 AM - SHORT COURSES
– “Ethical Considerations for the Evaluation of Research Protocols
in Animal Experimentation”
Adela Rosenkranz y Marcela Rebuelto
Atlantic Room
Facultad de Ciencias Exactas y Naturales y Facultad de Veterinaria,
Universidad de Buenos Aires.
–“Capillary Electrophoresis: From Basic to Clinical Research”
Valeria Tríppodi
Topacio Room
Cátedra de Control de Calidad, Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires.
“Identification of Genetic Mutations and Epigenetic Alterations
by MLPA and MS-MLPA”
María Roqué
Coral Room
– Instituto de Histología y Embriología Mendoza “Dr. Mario H. Burgos”,
Facultad de Ciencias Médicas, Universidad Nacional de CuyoCONICET.
9:00 AM-11:00 AM - SYMPOSIA
LEÓN CHERNY AWARD (SAIC)
Atlantic Room
Award Committee: Alejandro De Nicola, Marcelo Roma, Lucio
Castilla, Francisco Quintana and Alicia Belgorosky.
9:00 AM-9:25 AM – “Thyroid Hormones Contribute to the Malignant
Phenotype of Human T-Cell Lymphomas through the Regulation of Transcriptional Programs Differentially Initiated by
their Nuclear and Membrane Receptors”. María Florencia
Cayrol; Fernando Tharu; Mara Celeste Díaz Flaqué; Helena
Sterle; Eduardo Valli; Ricardo Farías; Ana Genaro; Leandro
Cerchietti; Graciela Cremaschi.
9:25 AM-9:50 AM – “On Estrogen Receptor Alpha and Integrin
Beta 1 or Why Estrogens Determine Environment Communication?”. Rocío Sampayo; Andrés Martín Toscani; Alfredo
Cáceres; Federico Coluccio Leskow; Marina Simian.
9:50 AM-10:15 AM – “Regeneration of Spinal Cord Traumatic Lesion by Dimeric Galectin-1 Treatment”. Héctor Quintá; Juana
M Pasquini; Gabriel A Rabinovich, Laura A Pasquini.
10:15 AM-10:40 AM – “Perinatal Asphyxia-induced Alterations and
Potential Therapeutic Strategy”. G. Ezequiel Saraceno; María
José Bellini; Juan I. Romero; Mariana Holubiec; Javier A. Muñiz;
Tamara Logica; Rodolfo Klliker-Frers; Marcela A. Brocco; Luis
M. García-Segura; Rocío Castilla; Francisco Capani.
10:40 AM-11:15 AM – “Antiprogestagens Facilitate Chemotherapeutic Nanoparticles Access in Breast Cancer with RP-A High
Expression”. Gonzalo Sequeira; Silvia Vanzulli; María May;
Caroline Lamb; Alfredo Molinolo; Claudia Lanari.
SAFE 2013 AWARD: SAFE YOUNG INVESTIGATOR
SYMPOSIUM
Topacio Room
Award Committee: Carlos Lanusse, Rodolfo Rothlin, Nora Brandán
and Sergio Sánchez-Bruni.
9:00 AM-9:30 AM - “Hialorunan-doxorubicin Ionic Complex Potential and in vitro Efficacy in Cultured Tumoral and Non-
Tumoral Cells.” Franco David Battistini; Jésica Flores-Martin;
María Eugenia Olivera; Susana Genti-Raimondi; Rubén Hilario
Manzo.
9:30 AM-10:00 AM - “The Expression of Citokins and Neurotrophins as Peripheral Markers of Cognitive Deficit. Therapeutic
Efficacy with Glatiramer Acetate.” María Laura Palumbo; Elías
Hugo Simón; Ana María Genaro.
10:00 AM-10:30 AM - “Participation of PSA-NCAM in Fluoxetininduced Pharmacological Effects in an Experimental Model
of Depression.” María Fernanda Podestá; Martín Gabriel
Codagnone; Mariano Saborido; Juan Ramiro Lorenzo López;
Reinés, Analía.
10:30 AM-11:00 AM - “Proteinase Composition Analysis in Yarará
Snake Venom by Using Toxin Specific Inhibitors and Antibodies.” Andrea Carolina Van de Velde; Claudia Carolina Gay;
Laura Cristina Leiva.
SAFIS 2013 AWARD: SAFIS YOUNG INVESTIGATOR
SYMPOSIUM
Chaired: Paula Ford and Viviana Catania
Award Committee: Osvaldo Rey, Susana Nowicky and Marta Roque.
9:00 AM-9:30 AM - MARÍA MARTA AMARAL. Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina;
Universidad de Buenos Aires
“The Effect of Shiga 2 and Subtilase Toxins on Primary Cultures of Human Glomerular Endotelial Cells”.
9:30 AM-10:00 AM - MARÍA LAURA CASELLA. INFISE – CONICET,
Rosario, Santa Fe.
“Quercetin Prevents Hepatocellular Carcinoma
by Stimulating Cell Cycle Arrest and Apoptosis
and by Reducing Cell Proliferation”.
10:00 AM-10:30 AM - JIMENA FERRARIS. INBIOMED, UBA-CONICET, Facultad de Medicina; Universidad de Buenos Aires
“Prolactin Antiapoptotic and Antiproliferative
Effects Maintain Adenohypophysis Homeostasis:
Possible Role of Prolactin in the Pathogenesis of
Pituitary Tumors”.
10:30 AM-11:00 AM - SILVINA VILLANUEVA. IFISE-CONICET,
Rosario, Santa Fe.
“Regulation of Multidrug Resistance Associated Protein 2 (MRP2) by glucagon-like peptide
1 (GLP-1) in CACO 2 cells. Involvement of cAMP
signalling pathway”.
11:00 AM-12:00 AM - CONFERENCES
SAIC CONFERENCE
Chaired: Juana María Pasquini
Atlantic Room
– SUSAN HORWITZ. Departament of Molecular Pharmacology, Albert
Einstein College of Medicine, New York, USA.
“Taxol®, Tubulin and Tumors”
7
SAIC-SAFIS-SAFE 2013 PROGRAM
SAIC CONFERENCE
Chaired: Enrique Luque
Topacio Room
– TYRONE HAYES. Department of Integrative Biology, Molecular Toxicology, Group in Endocrinology, Museum of Vertebrate Zoology, Energy
and Resources Group, University of California at Berkeley, USA.
“Clinical Concerns with Atrazine Exposure are supported by Laboratory Findings”
1:30 PM-3:30 PM - SYMPOSIA
Symposium 14: ENDOBIOTIC AND XENOBIOTIC
TRANSPORTERS: EVOLUTION, PHYSIOLOGY, PATHOPHYSIOLOGY AND CLINICAL APPLICATION (SAIC).
Chaired: Aldo Mottino
Atlantic Room
1:30 PM-2:05 PM - JOSE MANAUTOU. Center for Biochemical Toxicology, Department of Pharmaceutical Sciences, University of
Connecticut, USA.
4:00 PM-3-30 PM - ADRIANA GRUPPI. President of the Argentine
Immunology Society (SAI), ARGENTINA.
“Lymphocytes B, the Only Antibody Producing
Cells, Regulate Immune Response by proinflammatory and Antiinflammatory Cytokines”
Chaired: Basilio Kotsias
4:30 PM-5-00 PM - LUIS MAYORGA. President of the Argentine
Society of Research on Biochemistry and Molecular Biology
(SAIB), ARGENTINA.
“MRP4/ABCC4: A Multifaceted Conductor of Drug
Transport and Signal Transduction”.
Chaired: Elisa Bal de Kier Joffé
5:00 PM-5:30 PM - ALEJANDRO SCHINDER. President��������������
of the Argentine Society for Neurosciense Research (SAN), ARGENTINA.
2:40 PM-3:15 PM - VERÓNICA MATHET. Instituto de Investigaciones
en Microbiología y Parasitología Médica (IMPAM-CONICET),
Facultad de Medicina, Universidad de Buenos Aires, ARGENTINA.
4:00 PM-5:30 PM – SCIENTIFIC SOCIETIES SYMPOSIUM (SAIC).
Atlantic Room
“Studies on Multidrug Resistance Protein 4
(MRP4, ABCC4) as Potential Factor Conferring
Resistance to Hepatotoxicity Caused by Acetaminophen”.
2:05 PM-2:40 PM - FRANS RUSSEL. Radboud University Nijmegen
Medical Centre and the Faculty of Science, NETHERLANDS.
Preoteasome System”. Nadia Longo Carbajosa; Gerardo
Corradi; Marcelo Vatta; Mariela M Gironacci.
2�����������������������������������������������������������
:30 PM-3:00 PM – “Endocannnabinoid 2-AG Metabolism is Regulated by Agonists and/or Antagonists of Cannabinoid Receptors in Senile Rat Synaptosomes”. Ana Clara Pascual;
Virginia L. Gaveglio; Norma M. Gusto; Susana J. Pasquaré. 3:00 PM-3:30 PM – “Dissecting Reactive Gliosis: Role of DAMP
S100B and its Receptor RAGE in Reactive Gliosis Induction
and Ischemic Damage Propagation”. Alejandro Villarreal;
Roció Seoane; María Florencia Angelo; Martín M Dodes Traian;
Alberto Javier Ramos.
“Strategies to Improve Viral Hepatitis Therapeutics: Role of ABC Proteins in Multiple Drug
Resistance”.
Selected short talk:
3:15 PM-3:30 PM- “Insulin Reverses Gestational Diabetes-increased L-Arginine Transport Involving Activation of Insulin
Receptors A and B in the Human Umbilical Vein Endothelium”. Guzmán Gutiérrez E.; Sáez T.; Salsoso R.; Arroyo P.;
Pardo F.; Leiva A.; Sobrevia L.
EDUARDO SOTO AWARD (SAIC).
Award Committee: Eduardo Arzt, Ruth Rosenstein and José Belforte. Topacio Room
1:30 PM-2:00 PM – “Cognitive Changes and Brain Alterations in
Neurons and Glia Precede Amyloid Deposition in the Hippocampus of PDAPP-J20 Transgenic Mice, an Animal Model
of Alzheimer´s Disease”. Juan Beauquis; Ángeles Vinuesa;
Carlos Pomillo; Patricio Pavía; Flavia Saravia. 2:00 PM-2:30 PM – “Tyrosine Hydroxylase, an Enzyme Involved in
Hypertension Development, is Regulated by the Ubiquitin-
“Fusion of Cellular Membranes”
“From Stem Cells to Neurons: Dynamic Mechanisms Involved in the Plasticity of the Adult Brain”
Chaired: Eduardo Arzt
6:00 PM-7:30 PM- SCIENCE POLICY WORKSHOP
“Analysis and Articulation of Financial Tools for
Research in Health”
–ALEJANDRO MENTABERRY, Executive Coordinator of the Technologic Scientific Cabinet (GATEC). Ministry of Science, Technology
and Productive Innovation of Argentina.
– JAIME LAZOVSKI, Sub secretary of Sanitary Relations and Health
Research of the Ministry of Health of Argentina.
– ADRIANA GRUPPI, SAI President.
– FRANCISCO MAYORGA, SAIB President.
– ALEJANDRO SCHINDER, SAB President.
– DAMASIA BECU, SAFE President.
– CLAUDIA CAPURRO, SAFIS President.
– CARLOS DAVIO, SAIC President.
21:30 CLOSING DINNER
Hotel UTHGRA SASSO
Address: Avenida de los Trabajadores 3545, Punta Mogotes, Mar
del Plata.
Edición realizada por Estudio Sigma S.R.L. - J. E. Uriburu 1252 - 8º F - Buenos Aires - Tel.: 4824-9431 / 4821-2702
E-mail: [email protected] - www.estudiosigma.com.ar
Impreso en el mes de Noviembre de 2013