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Programa:
WEDNESDAY May 20th
16:00. Official Opening
16:15 IZASA presentation: “Image Analysis of Cells in Flow: Cell death & autophagy”
16:30-17:30, INAUGURAL CONFERENCE
Andreas Villunger; Medical University Innsbruck
(Chairman: Cristina Muñoz-Pinedo):
17:30-18:00 Coffee break
18:00-20:00. Session I. MOLECULAR MECHANISMS OF CELL DEATH:
MITOCHONDRIA AND CASPASES
(Chairman: Mari Carmen Ruiz)
18:00-18:20 “Mitochondrial priming in endometrial cancer”.
Mónica Sancho, Eva Colás, Jaume Reventós, Mar Orzáez.
18:20-18:40 “Modulating interactions among Bcl-2 proteins to improve cancer
therapies”.
Oscar Gonzalo, Laura Vela, Javier Naval, Isabel Marzo.
18:40-19:00 “Knocking out mitochondrial carrier homolog 1 in Drosophila”
Lidia Martínez-Sánchez, Ramiro Vicente Blasco, María Alejandra Nelo Bazán, Janne
Markus Toivonen, Rafael Garesse, Miguel Fernández Moreno, Juan José Arredondo,
José Alberto Carrodeguas
19:00- 19:20 “Molecular mechanisms of Caspase-8 activation under glucose
deprivation”
Raffaella Iurlaro, Daniel Palou-Gramon, Estefanía Lucendo y Cristina Muñoz-Pinedo
19:20-19:40 “Pro-caspase-9 activators for breast cancer treatment”.
Yadira Palacios-Rodríguez, Tatiana Guevara, Christian De Ford, Pablo Luján, Mónica
Sancho, Guillermo García-Laínez, Angel Messeguer, Enrique Pérez-Payá and Mar
Orzáez.
19:40-20:00 "Low levels of DFF40/CAD in glioblastoma cells impair DNA laddering
during caspase-dependent apoptosis".
María Sánchez Osuna y Víctor Yuste.
THURSDAY May 21st
09:00-11:00 SESSION II: CELL DEATH AND SURVIVAL
(Chairman: Mar Orzaez )
09:00-09:20 “Dictyostelium as a model to study cellular competition and
programmed cell death”
Teresa Suárez y Enrique J. de la Rosa.
09:20 -09:40 “EndoG promotes cell division influencing embryonic cardiogenesis”.
Natividad Blasco y Daniel Sanchis.
09:40-10:00 “PARP1-mediated regulation of survival pathways in glioblastoma”
Jara Majuelos and Javier Oliver
10:00-10:20 “Role of necroptosis in renal damage”
Ana B. Sanz, Diego Martin, Olga Ruiz Andrés, Alberto Ortiz
10:20 – 10:40 “Cyclin O preserves genomic stability and is necessary for ciliogenesis.
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Marc Núñez, Alex Balsiger, Marta Garrido, Ramon Roset, Pablo Huertas, Carole Jung,
Cristina Plata, Miguel A. Valverde and Gabriel Gil-Gómez.
10:40-11:00 “A pro-survival role for the plant metacaspase AtMC1 in proteostasis”.
Nùria Coll
11:00-11:30 Coffee break
11:30-13:30 SESSION III: AUTOPHAGY AND METABOLISM
(Chairman: Isabel Marzo )
11:30-11:50 “Role of autophagy during the development of the vertebrate nervous
system.”
Lorena Esteban, Esther Seco, Patricia Boya .
11:50-12:10 “Role of cholesterol in β-amiloid-induced autophagy”
E. Barbero, A Colell.
12:10-12:30 “Glucose deprivation and 2-deoxyglucose induce different forms of cell
death but both are mediated by ATF4”
Clara Lucía León Annicchiarico, Silvia Ramirez-Peinado; Anika Gonsberg, Theodore
Lampidis, Cristina Muñoz Pinedo.
12:30-12:50 “Macrophage autophagy induction by bioactive lipids”.
Patricia Prieto Chinchilla, César Rosales, María Fernandez Velasco y Lisardo Boscá
12:50-13:10 “ Glutamine metabolism and TRAIL sensitivity in breast carcinoma cells”
Marta Mauro y Abelardo López-Rivas
13:30-15:30 lunch
15:30- 17:30 SESSION IV: CELL DEATH IN NERVOUS SYSTEM
(Chairman: Victor Yuste).
15:30-15:50 “Lysosomal damage in a mouse model of retinal degeneration”
Ana Serrano-Puebla, Natalia Rodríguez-Muela, Alberto Miguel Hernández-Pinto, Lucía
García-Ledo, Enrique J. de la Rosa and Patricia Boya.
15:50-16:10 “Involvement of P75, the pro-neurotrophin receptor, in retinal
neurodegeneration”.
María Platón y Enrique J. de la Rosa.
16:10-16:30 “Role of Siva-1 in the nervous system”
Elena Coccia and Joan Comella
16:30-16:50 “Role of the death receptor antagonist FAIM-L in axon degeneration”.
Bruna Barneda-Zahonero and J. Comella
16:50-17:10 “Two extra FAIM isoforms”
Laura Planells-Ferrer and Joan Comella
17:30-18:00 Coffee break
18:00-20:00 DEATH RECEPTOR SIGNALING AND THERAPY.
(Chairman: Gael Roue )
18:00-18:20 “Dual role of MAPK/Erk pathway in the regulation of TRAIL sensitivity”
Ana Cano-González y Abelardo López-Rivas
18:20-18:40 “Highly bioactive formulations of Apo2l/TRAIL for cancer treatment”
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Diego De Miguel Samaniego, Ana Gallego Lleyda, Miguel Martínez Ara, José María
Ayuso Domínguez, Sandra Erviti Ardanaz, Ignacio Ochoa Garrido, Luis J. Fernández
Ledesma, Celia del Agua Arias, Roberto Pazo Cid, Alberto Anel, Luis Martinez-Lostao.
18:40-19:00 “Synergistic activity of the IAPs inhibitor AEG40730 and the human antiTRAIL-R1 antibody mapatumumab in in vitro and in vivo models of mantle cell
lymphoma".
Anna Esteve, Alexandra Moros, Anna Gresely, Anna Bellmunt, Elisenda Casanelles,
Vanina Rodríguez, Dolors Colomer, Antonio Martinez, Victor J Yuste, Patricia PérezGalán, and Gaël Roué.
19:00-19:20 “Different approaches to sensitize Glioblastoma cells to TRAIL-induced
apoptosis”
Santiago Serrano, Abelardo López-Rivas, Javier Oliver
19:20-19:40 “TNFα sensitizes neuroblastoma cells to FasL-, cisplatin-, and etoposideinduced cell death by NFκB-mediated expression of Fas”.
Koen Galenkamp and Joan Comella.
19:40-20:00 “Lipid raft platforms in apoptosis regulation”
Faustino Mollinedo & Consuelo Gajate
FRIDAY May 22nd
09:00-10:20 SESSION VI: SESSION V: IMMUNE SYSTEM
(Chairman: Luis Martínez-Lostao)
09:00-09:20 “Activation of human allogeneic Natural Killer cells to target
chemoresistant cancer cells”
Pilar Lanuza, Diego Sánchez, Santiago Costas and Julián Pardo
09:20-09:40 Cell-to-cell protein transfer from multiple myeloma (MM) cells to cord
blood derived natural killer cells (CB-NK) and from CB-NK to MM. Implications for cell
death and tumor cell survival”
Beatriz Martín-Antonio, Erica Serrano, Alvaro Urbano-Ispizua
09:40-10:00 “Role of inflammation and cell death induced by granzymes A and B
during inflammatory colorectal carcinoma”
Llipsy Santiago, Marta Castro, Maykel Arias, Paula Jaime, Guillermo Muñoz, Angel
Ferrandez, Anabel Alcalde and Julián Pardo.
10:00-10:20 “Granulysin as novel anti-tumoral therapy: Precilinical studies”
Sameer Al-Wasaby, Diego de Miguel, Adriana Aporta, Javier Naval, Laura Sanz,
Blanca Conde, Luis Martínez-Lostao, Alberto Anel
10:20-10:40 Coffee break
10:40-12:40 SESSION VII: CANCER
(Chairman: Abelardo Lopez )
10:40-11:00 " BMP9-induced survival effect in hepatocarcinoma cells requires
p38MAPK activation "
María García-Álvaro, Annalisa Addante, César Roncero, Margarita Fernández, Isabel
Fabregat, Aránzazu Sánchez and Blanca Herrera.
11:00-11:20 "Disruption of MYC signalling by BET bromodomain inhibition in B-cell
lymphoma".
Anna Esteve, Alexandra Moros, Anna Gresely, Anna Bellmunt, Elisenda Casanelles,
Vanina Rodríguez, Dolors Colomer, Antonio Martinez, Victor J Yuste, Patricia PérezGalán, and Gaël Roué.
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11:20-11:40 “Mechanism of apoptosis induced by hydralazine leukemic T cells".
M José Ruiz-Magaña, Estefanía Lucendo, Diana Campillo, M. Carmen Ruiz-Ruiz
11:40-12:00 "The prohibitin-binding compound fluorizoline induces the mitochondrial
apoptotic pathway through Noxa and Bim upregulation.”.
José Saura-Esteller, Cristina Moncunill-Massaguer, Alba Pérez-Perarnau, Claudia
Mariela Palmeri, Sonia Núñez-Vázquez, Ana M. Cosialls, Diana M. González-Gironès,
Helena Pomares, Anne Korwitz, Sara Preciado, Fernando Albericio, Rodolfo Lavilla,
Gabriel Pons, Thomas Langer, Daniel Iglesias-Serret and Joan Gil.
12:00-12:20“Effect of Carfilzomib and its combination with Chloroquine in Multiple
Myeloma cells”
Vidal Jarauta, Paula Jaime, Isabel Marzo, Julián Pardo, Javier Naval
12:20-12:40 “Biomimetic microfluidic devices: Advanced tumor models for apoptosis
monitoring"
Vigueras A., Virumbrales M., Olave M., Monge R., Ayuso J.M., Llamazares G., Ochoa I
and Fernandez L.
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