1. Ciencia

Circulation
Volume 131 ◼ Number 5
February 3, 2015
Clinical Summaries. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 443
Editorials
Mapping Hyperlipidemia in Young Adulthood to Coronary Risk: Importance of Cumulative Exposure
and How to Stay Young
Seth S. Martin, MD, MHS; Erin D. Michos, MD, MHS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 445
A Bridge Too Far?: Findings of Bridging Anticoagulation Use and Outcomes in the Outcomes Registry
for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)
Amir Y. Shaikh, MD; David D. McManus, MD, ScM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 448
Original Articles
Epidemiology and Prevention
Hyperlipidemia in Early Adulthood Increases Long-Term Risk of Coronary Heart Disease
Ann Marie Navar-Boggan, MD, PhD; Eric D. Peterson, MD, MPH; Ralph B. D’Agostino, Sr, PhD;
Benjamin Neely, MS; Allan D. Sniderman, MD; Michael J. Pencina, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 451
Heart Failure
Paradoxical Muscle Sympathetic Reflex Activation in Human Heart Failure
Philip J. Millar, PhD; Hisayoshi Murai, MD, PhD; John S. Floras, MD, DPhil . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 459
Interventional Cardiology
Arrhythmia Burden in Elderly Patients With Severe Aortic Stenosis as Determined by Continuous
Electrocardiographic Recording: Toward a Better Understanding of Arrhythmic Events After Transcatheter
Aortic Valve Replacement
Marina Urena, MD; Salim Hayek, MD; Asim N. Cheema, MD; Vicenç Serra, MD; Ignacio J. Amat-Santos, MD;
Luis Nombela-Franco, MD; Henrique B. Ribeiro, MD; Ricardo Allende, MD; Jean-Michel Paradis, MD;
Eric Dumont, MD; Vinod H. Thourani, MD; Vasilis Babaliaros, MD; Jaume Francisco Pascual, MD;
Carlos Cortés, MD; Bruno García del Blanco, MD; François Philippon, MD; Stamatios Lerakis, MD;
Josep Rodés-Cabau, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 469
Resuscitation Science
Amplitude Spectrum Area to Guide Defibrillation: A Validation on 1617 Patients With Ventricular Fibrillation
Giuseppe Ristagno, PhD; Tommaso Mauri, MD; Giancarlo Cesana, MD; Yongqin Li, PhD; Andrea Finzi, PhD;
Francesca Fumagalli, MBiol; Gianpiera Rossi, MD; Niccolò Grieco, MD; Maurizio Migliori, MD;
Aida Andreassi, MD; Roberto Latini, MD; Carla Fornari, PhD; Antonio Pesenti, MD;
the Azienda Regionale Emergenza Urgenza (AREU) Research Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 478
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Vascular Medicine
Use and Outcomes Associated With Bridging During Anticoagulation Interruptions in Patients With Atrial
Fibrillation: Findings From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation
(ORBIT-AF)
Benjamin A. Steinberg, MD, MHS; Eric D. Peterson, MD, MPH; Sunghee Kim, PhD; Laine Thomas, PhD;
Bernard J. Gersh, MBChB, DPhil; Gregg C. Fonarow, MD; Peter R. Kowey, MD; Kenneth W. Mahaffey, MD;
Matthew W. Sherwood, MD, MHS; Paul Chang, MD; Jonathan P. Piccini, MD, MHS; Jack Ansell, MD;
on behalf of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigators and Patients CME
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 488
Drug-Coated Balloon Versus Standard Percutaneous Transluminal Angioplasty for the Treatment of
Superficial Femoral and Popliteal Peripheral Artery Disease: 12-Month Results From the IN.PACT SFA
Randomized Trial
Gunnar Tepe, MD; John Laird, MD; Peter Schneider, MD; Marianne Brodmann, MD; Prakash Krishnan, MD;
Antonio Micari, MD; Christopher Metzger, MD; Dierk Scheinert, MD; Thomas Zeller, MD;
David J. Cohen, MD, MSc; David B. Snead, PhD; Beaux Alexander, MBA; Mario Landini, MS;
Michael R. Jaff, DO; for the IN.PACT SFA Trial Investigators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 495
Challenges and Opportunities in Pediatric Heart Failure and Transplantation
Pharmacogenomics: Personalizing Pediatric Heart Transplantation
Sara L. Van Driest, MD, PhD; Steven A. Webber, MBChB, MRCP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 503
ECG Challenge
ECG Challenge: February 3, 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 513
Images in Cardiovascular Medicine
Limited Cutaneous Pseudovasculitis: A Mild Variant of Cholesterol Emboli Syndrome
Oluwatobi A. Ogbechie, BA; Keith W. Morley, MD; Daniel Sugai, MD; Vinod E. Nambudiri, MD, MBA;
Maryanne M. Senna, MD; Mai P. Hoang, MD; Arturo P. Saavedra, MD, PhD, MBA . . . . . . . . . . . . . . . . . . . . . . . . . . . 514
Mammoth Ventricular Hypertrophy
Michael A. Bauml, MD; Afshin Farzaneh-Far, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e327
Cardiology Patient Page
Heart Smart Guide for Young Patients With Cardiac Devices
Katherine Cutitta, MA; Rebecca Ladd, MA; Jessica Buzenski, BA; David Fairbrother, MD; Samuel F. Sears, PhD . . e330
Correspondence
Letter by Weinrauch and Barkoudah Regarding Article, “Lack of Concordance Between Empirical Scores
and Physician Assessments of Stroke and Bleeding Risk in Atrial Fibrillation. Results From the Outcomes
Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry”
Larry A. Weinrauch, MD; Ebrahim Barkoudah, MD, MPH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e335
Letter by Haft Regarding Article, “Temporal Relationship Between Subclinical Atrial Fibrillation
and Embolic Events”
Jacob I. Haft, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e336
Response to Letter Regarding Article “Temporal Relationship Between Subclinical Atrial Fibrillation and
Embolic Events”
Jeff S. Healey, MD; Michela Brambatti, MD; Michael R. Gold; Carlos A. Morillo, MD; Alessandro Capucci, MD;
Carmine Muto, MD; Chu P. Lau, MD; Isabelle C. Van Gelder, MD; Stefan H. Hohnloser, MD; Mark Carlson, MD;
Eric Fain, MD; Juliet Nakamya, PhD; Georges H. Mairesse, MD; Marta Halytska, BSc; Wei Q. Deng, MSc;
C.W. Israel, MD; Stuart J. Connolly, MD; on behalf of the ASSERT Investigators . . . . . . . . . . . . . . . . . . . . . . . . . . . . e337