Symposium at FOCIS 2015 Wednesday, June 24, 2015, 8:00AM-12:00PM Sapphire H, Hilton San Diego Bayfront Hotel CNS Autoimmune Disease and the Innate Immune System: Novel Roles of Pro-inflammatory and Regulatory Myeloid Cells Session Chair: Benjamin M. Segal, M.D., University of Michigan (Ann Arbor, MI, USA) Granulocytes in autoimmune demyelinating disease 8:00-8:30 Neutrophils mediate blood-brain-barrier disruption in EAE Luc Vallieres, PhD, Centre Hospitalier Université Laval (Quebec, Quebec, CA) 8:30-9:00 Neutrophil attracting CXC chemokines and G-CSF in EAE and MS pathogenesis Julie Rumble, PhD, University of Michigan (Ann Arbor, MI, USA) 9:00-9:30 Mast cell activation, neutrophil recruitment and meningeal inflammation in the formation of demyelinating lesions Melissa Brown, PhD, Northwestern University (Chicago, IL, USA) 9:30-10:00 SOCS3/STAT3 axis in myeloid cells regulates neuroinflammation Etty Benveniste, PhD, University of Alabama (Birmingham, AL, USA) 10:00-10:15 Break Polarized monocytes, macrophages and microglial subsets: Implications for Pathogenesis, Immunoregulation and Repair in MS 10:15-10:45 Polarization Properties of Human Myeloid Cell Populations Jack Antel, MD, McGill University (Montreal, Quebec, CA) 10:45-11:15 The role of different antigen presenting cells in autoimmune demyelination Ari Waisman, PhD, Johannes Gutenberg-University Mainz (Mainz, DE) 11:15-11:45 Microglia and macrophage activation in remyelination Veronique Miron, PhD, University of Edinburgh (Edinburgh,UK) 11:45-12:00 Closing Remarks