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WORKSHOPS
“CURRENT TRENDS IN
BIOMEDICINE”
2014
CAMPUS ANTONIO MACHADO
BAEZA, SPAIN
PROTEASES AT WORK:
CUES FOR UNDERSTANDING
NEURAL DEVELOPMENT
AND NEURODEGENERATION
Baeza, Spain • 20th-22nd October 2014
Organized by:
Paola Bovolenta
Centro de Biología Molecular “Severo
Ochoa”, CSIC-UAM. Madrid, Spain.
Paul Saftig
Institut für Biochemie, ChristianAlbrechts-Universität zu Kiel. Kiel,
Germany.
SCOPE
Proteolytical processing of membrane bound molecules is emerging as a
fundamental mechanism for controlling the strength and timing of cell-tocell communication, which is at the basis of tissue development and
homeostasis. This process acquires particular importance in the context of
the brain because its function strongly depends on well-orchestrated
interactions among many different cell types. Members of families of
metalloproteinases are major effectors of these events. Understanding how
proteinases, particularly metalloproteinases, coordinate brain development
or how they contribute to brain pathologies when disregulated, requires
multi-disciplinary approaches tackling the problem from different
perspectives. This workshop will summarize the most recent biochemical
and genetic evidence demonstrating that proteases are required for
development, function and homeostasis of the CNS, underscoring their
relevance in neurodegeneration and discussing whether endogenous or
pharmacological modulation of their activity represents a therapeutic tool
to prevent synaptic loss, neural defects or brain diseases.
FORMAT OF THE WORKSHOP
The workshop will bring together 15 speakers and a maximum of 33-35
participants, to form a group of around 50 people. The scientific
programme will start in the morning of Monday, October 20th, and will end
around noon on Wednesday, October 22nd. Ample time for informal
discussion will be reserved. Participants will be invited to present a poster.
VENUE OF THE WORKSHOP
The workshop will be held in Baeza, at the “Campus Antonio Machado”, a
XVII century building turned into a Conference Centre of the Universidad
Internacional de Andalucía (UNIA). This Seat includes a recently restored
residence, where participants will be accommodated. Baeza is a World
Historic Heritage town, renowned for its Renaissance and Gothic buildings.
SPEAKERS
Carl P. Blobel
Arthritis and Tissue Degeneration Program,
Hospital for Special Surgery / Departments of
Medicine and of Physiology, Biophysics and
Systems Biology, Weill Medical College of
Cornell University. New York, NY, USA.
Paola Bovolenta
Centro de Biología Molecular “Severo Ochoa”,
CSIC-UAM / CIBER de Enfermedades Raras
(CIBERER). Madrid, Spain.
Elena Cattaneo
Department of Biosciences and Center for Stem
Cell Research, Università degli Studi di Milano.
Milan, Italy.
Bart De Strooper
KU Leuven Center for Human Genetics and
Leuven research Institute for Neuroscience and
Disease (LIND) / VIB Center for the Biology of
Disease. Leuven, Belgium.
Kristina Endres
Department of Psychiatry and Psychotherapy,
University Medical Center of the Johannes
Gutenberg University Mainz. Mainz, Germany.
Pilar Esteve
Centro de Biología Molecular “Severo Ochoa”,
CSIC-UAM / CIBER de Enfermedades Raras
(CIBERER). Madrid, Spain.
Isabel Fariñas
Departamento de Biología Celular, Universidad de
Valencia / Centro de Investigación Biomédica en
Red sobre Enfermedades Neurodegenerativas
(CIBERNED). Valencia, Spain.
Nigel M. Hooper
Institute of Brain, Behaviour and Mental Health,
Faculty of Medical and Human Sciences,
University of Manchester. Manchester, UK.
Leszek Kaczmarek Department
of
Molecular
and
Cellular
Neurobiology,
The
Nencki
Institute
of
Experimental Biology. Warsaw, Poland.
Patricia F. Maness Department of Biochemistry and Biophysics,
University of North Carolina School of Medicine.
Chapel Hill, NC, USA.
Lieve Moons
Laboratory of Neural Circuit Development and
Regeneration,
Animal
Physiology
and
Neurobiology Section, Department of Biology,
KU Leuven. Leuven, Belgium.
Paul Saftig
Institut für Biochemie, Christian-AlbrechtsUniversität zu Kiel. Kiel, Germany.
Shanthini Sockanathan
The Solomon Snyder Department of
Neuroscience, The Johns Hopkins University
School of Medicine. Baltimore, MD, USA.
Taisuke Tomita
Department of Neuropathology and Neuroscience,
Graduate School of Pharmaceutical Sciences, The
University of Tokyo. Tokyo, Japan.
Avraham Yaron
Department of Biological Chemistry, Weizmann
Institute of Science. Rehovot, Israel.
DEADLINE: 5th SEPTEMBER 2014
MORE INFORMATION AND APPLICATION:
http://www.unia.es/biomedicine
Universidad Internacional de Andalucía
Campus Antonio Machado
Palacio de Jabalquinto
Plaza de Santa Cruz, s/n. 23440 Baeza (Jaén), Spain
Tel: +34 953 74 27 75. Fax: +34 953 74 29 75. E-mail: [email protected]