chaperones in the maintenance of cellular proteostasis

WORKSHOPS
“CURRENT TRENDS IN
BIOMEDICINE”
2016
CAMPUS ANTONIO MACHADO
BAEZA, SPAIN
CHAPERONES IN THE
MAINTENANCE OF
CELLULAR PROTEOSTASIS
Baeza, Spain • 17th-19th October 2016
Organized by:
José María Valpuesta Centro Nacional de Biotecnología
(CNB-CSIC). Madrid, Spain.
Ana María Cuervo
Institute for Aging Studies, Albert
Einstein College of Medicine. New
York, USA.
Cintia Roodveldt
CABIMER-Andalusian Center for
Molecular Biology and Regenerative
Medicine. Sevilla, Spain.
Sponsors:
The Company of Biologists Limited ( www.biologists.com ) will cover
the workshop fees (registration and/or accommodation-meals) of some
participants, selected by the organizers after the deadline.
SCOPE
Molecular chaperones comprise a large group of proteins originally
characterized as involved in assisting the folding of many proteins.
However, it has become clear that their roles are much more complex and
diverse, including disaggregation of aggregated species and targeting for
protein degradation, among other activities. Molecular chaperones have
been extensively studied at the structural and biochemical levels and their
cellular role as main proteostasis regulators is well supported. Growing
evidence revealing that alterations in cellular quality control underlie the
pathogenic basis for severe common human neurodegenerative disorders
such as Alzheimer’s or Parkinson’s diseases, has brought molecular
chaperones back to stardom in recent years. In fact, the tight functional
interactions between molecular chaperones and the cellular systems
involved in protein clearance, such as the ubiquitin-proteasome system and
autophagy, have unveiled chaperones as essential components of the
cellular and organismal proteostasis networks. These recent links with
human diseases have propelled the vertiginous expansion that the field of
molecular chaperones has undergone in recent years (> 8000 papers in the
last five years). The goal of this meeting is to facilitate the communication
among the different fields of research currently interested in the roles of
molecular chaperones in cellular proteostasis, as well as to foment an
integrated approach to defining the contribution of alterations in this
process to pathological conditions and to exploring their value as potential
therapeutic targets.
FORMAT OF THE WORKSHOP
The workshop will bring together a maximum of 17 speakers and 35
participants, to form a group of around 50 people. The scientific
programme will start in the morning of Monday, October 17 th, and will end
around noon on Wednesday, October 19th. Ample time for informal
discussion will be reserved. Participants will be invited to present a poster.
VENUE OF THE WORKSHOP
The workshop will be held in Baeza, at the “Campus Antonio Machado”, a
XVII century building turned into a Conference Centre of the Universidad
Internacional de Andalucía (UNIA). This Seat includes a residence, where
participants will be accommodated. Baeza is a World Historic Heritage
town, renowned for its Renaissance and Gothic buildings.
SPEAKERS
Johannes Buchner Center for Integrated Protein Science at the
Department Chemie, Technische
München. Garching, Germany.
Bernd Bukau
Universität
Center for Molecular Biology of the University of
Heidelberg (ZMBH) / German Cancer Research
Center. Heidelberg, Germany.
Ana María Cuervo Department of Developmental and Molecular
Biology, Institute for Aging Studies, Albert
Einstein College of Medicine. New York, NY,
USA.
Douglas M. Cyr
Department of Cell Biology and Physiology,
School of Medicine, University of North Carolina.
Chapel Hill, NC, USA.
Judith Frydman
Department of Biology and Genetics, Stanford
University. Stanford, CA, USA.
Carmen Garrido
INSERM, UMR 866, Université de Bourgogne,
Anticancer Center Georges François Leclerc.
Dijon, France.
Jason E. Gestwicki Department
of Pharmaceutical Chemistry,
University of California at San Francisco. San
Francisco, CA, USA.
Lila M. Gierasch
Department of Biochemistry and Molecular
Biology and Department of Chemistry, University
of Massachusetts. Amherst, MA, USA.
F. Ulrich Hartl
Department of Cellular Biochemistry, Max Planck
Institute of Biochemistry. Martinsried, Germany.
Jörg Höhfeld
Institute for Cell Biology, Rheinische FriedrichWilhelms-University Bonn. Bonn, Germany.
Harm H. Kampinga University Medical Center Groningen, University
of Groningen, Department of Cell Biology.
Groningen, The Netherlands.
Guillermo Montoya Macromolecular Crystallography Group, Novo
Nordisk Foundation Center for Protein Research,
Faculty of Health and Medical Sciences,
University
of
Copenhagen.
Copenhagen,
Denmark.
Arturo Muga
Unidad de Biofísica (CSIC-UPV/EHU) y
Departamento de Bioquímica y Biología
Molecular, Facultad de Ciencia y Tecnología,
Universidad del País Vasco (UPV/EHU). Bilbao,
Spain.
Cintia Roodveldt
CABIMER-Andalusian Center for Molecular
Biology and Regenerative Medicine. Sevilla,
Spain.
Laura Santambrogio
Department of Pathology / Department of
Microbiology and Immunology, Albert Einstein
College of Medicine. New York, NY, USA.
José María Valpuesta
Department of Macromolecular Structure,
Centro Nacional de Biotecnología (CNB-CSIC).
Madrid, Spain.
Juan Carlos Zabala Departamento de Biología Molecular, Facultad de
Medicina, IDIVAL-Universidad de Cantabria.
Santander, Spain.
DEADLINE: 2nd SEPTEMBER 2016
MORE INFORMATION AND APPLICATION:
http://www.unia.es/biomedicine
workshops.biomed@unia.es
Universidad Internacional de Andalucía
Campus Antonio Machado
Palacio de Jabalquinto
Plaza de Santa Cruz, s/n. 23440 Baeza (Jaén), Spain
Tel: +34 953 74 27 75. Fax: +34 953 74 29 75. E-mail: baeza@unia.es