1. Healthcare

FEBRUARY 2015 • VOLUME 59 • NO. 2
TABLE OF CONTENTS
CHEMISTRY; BIOSYNTHESIS
In Vitro Cytotoxic Effects of Gold Nanoparticles Coated with
Functional Acyl Homoserine Lactone Lactonase Protein from
Bacillus licheniformis and Their Antibiofilm Activity against
Proteus Species
Gopalakrishnan Vinoj, Rashmirekha
Pati, Avinash Sonawane, Baskaralingam
Vaseeharan
763–771
Structural Variations of the Cell Wall Precursor Lipid II and
Their Influence on Binding and Activity of the Lipoglycopeptide
Antibiotic Oritavancin
Daniela Münch, Ina Engels, Anna
Müller, Katrin Reder-Christ, Hildegard
Falkenstein-Paul, Gabriele Bierbaum,
Fabian Grein, Gerd Bendas, HansGeorg Sahl, Tanja Schneider
772–781
Mechanisms of Action of Substituted ␤-Amino Alkanols on
Leishmania donovani
María Ángeles Abengózar, Luis A.
Bustos, Raquel García-Hernández, Pilar
Fernández de Palencia, Ricardo
Escarcena, Santiago Castanys, Esther
del Olmo, Francisco Gamarro, Arturo
San Feliciano, Luis Rivas
1211–1218
Subinhibitory Concentrations of LFF571 Reduce Toxin
Production by Clostridium difficile
Meena Sachdeva, Jennifer A. Leeds
1252–1257
MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS
MECHANISMS OF RESISTANCE
16S rRNA Gene Mutations Associated with Decreased
Susceptibility to Tetracycline in Mycoplasma bovis
E. Amram, I. Mikula, C. Schnee,
R. D. Ayling, R. A. J. Nicholas,
R. S. Rosales, S. Harrus, I. Lysnyansky
796 – 802
Evolution and Transmission Patterns of Extensively
Drug-Resistant Tuberculosis in China
Feifei Wang, Lingyun Shao, Xiaoping
Fan, Yaojie Shen, Ni Diao, Jialin Jin,
Feng Sun, Jing Wu, Jiazhen Chen,
Xinhua Weng, Xunjia Cheng, Ying
Zhang, Wenhong Zhang
818 – 825
FabH Mutations Confer Resistance to FabF-Directed Antibiotics
in Staphylococcus aureus
Joshua B. Parsons, Jiangwei Yao,
Matthew W. Frank, Charles O. Rock
849 – 858
Characterization of Plasmids in Extensively Drug-Resistant
Acinetobacter Strains Isolated in India and Pakistan
Lim S. Jones, Maria J. Carvalho,
Mark A. Toleman, P. Lewis White,
Thomas R. Connor, Ammara Mushtaq,
Janis L. Weeks, Karthikeyan K.
Kumarasamy, Katherine E. Raven,
M. Estée Török, Sharon J. Peacock,
Robin A. Howe, Timothy R. Walsh
923–929
Unexpected Challenges in Treating Multidrug-Resistant
Gram-Negative Bacteria: Resistance to Ceftazidime-Avibactam
in Archived Isolates of Pseudomonas aeruginosa
Marisa L. Winkler, Krisztina M. PappWallace, Andrea M. Hujer, T. Nicholas
Domitrovic, Kristine M. Hujer, Kelly N.
Hurless, Marion Tuohy, Geraldine
Hall, Robert A. Bonomo
1020 –1029
Molecular Mechanisms of Fluconazole Resistance in Candida
parapsilosis Isolates from a U.S. Surveillance System
Nina T. Grossman, Cau D. Pham,
Angela A. Cleveland, Shawn R.
Lockhart
1030 –1037
Macrolide-Resistant Mycoplasma pneumoniae in Adults in
Zhejiang, China
Zibo Zhou, Xiangzhi Li, Xiaojian Chen,
Fangjun Luo, Changwang Pan,
Xiaoping Zheng, Feng Tan
1048 –1051
Instructions to Authors are available at http://journalitas.asm.org/t/46519.
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FEBRUARY 2015 • VOLUME 59 • NUMBER 2
Identification and Deconvolution of Cross-Resistance Signals
from Antimalarial Compounds Using Multidrug-Resistant
Plasmodium falciparum Strains
Monika Chugh, Christian Scheurer,
Sibylle Sax, Elizabeth Bilsland,
Donelly A. van Schalkwyk, Kathryn J.
Wicht, Natalie Hofmann, Anil Sharma,
Sridevi Bashyam, Shivendra Singh,
Stephen G. Oliver, Timothy J. Egan,
Pawan Malhotra, Colin J. Sutherland,
Hans-Peter Beck, Sergio Wittlin,
Thomas Spangenberg, Xavier C. Ding
1110 –1118
Genomic Insights into Intrinsic and Acquired Drug Resistance
Mechanisms in Achromobacter xylosoxidans
Yongfei Hu, Yuying Zhu, Yanan Ma,
Fei Liu, Na Lu, Xi Yang, Chunguang
Luan, Yong Yi, Baoli Zhu
1152–1161
Evolution of Carbapenem-Resistant Acinetobacter baumannii
Revealed through Whole-Genome Sequencing and Comparative
Genomic Analysis
Henan Li, Fei Liu, Yawei Zhang,
Xiaojuan Wang, Chunjiang Zhao,
Hongbin Chen, Feifei Zhang, Baoli
Zhu, Yongfei Hu, Hui Wang
1168 –1176
AbuO, a TolC-Like Outer Membrane Protein of Acinetobacter
baumannii, Is Involved in Antimicrobial and Oxidative Stress
Resistance
Vijaya Bharathi Srinivasan, Vasanth
Vaidyanathan, Govindan Rajamohan
1236 –1245
Complete Nucleotide Sequences of Two NDM-1-Encoding
Plasmids from the Same Sequence Type 11 Klebsiella
pneumoniae Strain
V. Studentova, H. Dobiasova,
D. Hedlova, M. Dolejska,
C. C. Papagiannitsis, J. Hrabak
1325–1328
Isolation of VIM-2-Producing Pseudomonas monteilii Clinical
Strains Disseminated in a Tertiary Hospital in Northern Spain
Alain A. Ocampo-Sosa, Laura P.
Guzmán-Gómez, Marta FernándezMartínez, Elena Román, Cristina
Rodríguez, Francesc Marco, Jordi Vila,
Luis Martínez-Martínez
1334 –1336
Novel Conjugative Plasmid from Escherichia coli of Swine
Origin That Coharbors the Multiresistance Gene cfr and the
Extended-Spectrum-␤-Lactamase Gene blaCTX-M-14b
Wan-Jiang Zhang, Xiu-Mei Wang,
Lei Dai, Xin Hua, Zhimin Dong, Stefan
Schwarz, Siguo Liu
1337–1340
Mechanism of Reduced Vancomycin Susceptibility Conferred by
walK Mutation in Community-Acquired Methicillin-Resistant
Staphylococcus aureus Strain MW2
Jinfeng Hu, Xu Zhang, Xiaoyu Liu,
Chuan Chen, Baolin Sun
1352–1355
Detailed Mutational Analysis of Vga(A) Interdomain Linker:
Implication for Antibiotic Resistance Specificity and Mechanism
Jakub Lenart, Vladimir Vimberg,
Ludmila Vesela, Jiri Janata, Gabriela
Balikova Novotna
1360 –1364
Broad Coverage of Genetically Diverse Strains of Clostridium
difficile by Actoxumab and Bezlotoxumab Predicted by In Vitro
Neutralization and Epitope Modeling
Lorraine D. Hernandez, Fred Racine,
Li Xiao, Edward DiNunzio, Nichelle
Hairston, Payal R. Sheth, Nicholas J.
Murgolo, Alex G. Therien
1052–1060
In Vitro Activity of Ceftazidime-Avibactam Combination in
In Vitro Checkerboard Assays
Johanna Berkhout, Maria J. Melchers,
Anita C. van Mil, Wright W. Nichols,
Johan W. Mouton
1138 –1144
Lactate as a Novel Quantitative Measure of Viability in
Schistosoma mansoni Drug Sensitivity Assays
Stephanie Howe, Dorina Zöphel,
Harini Subbaraman, Clemens Unger,
Jana Held, Thomas Engleitner,
Wolfgang H. Hoffmann, Andrea
Kreidenweiss
1193–1199
Susceptibility Profiles of Amphotericin B and Posaconazole
against Clinically Relevant Mucorales Species under Hypoxic
Conditions
Elisabeth Maurer, Ulrike Binder,
Manuela Sparber, Michaela Lackner,
Rita Caramalho, Cornelia Lass-Flörl
1344 –1346
Synergistic Activity of Chloroquine with Fluconazole against
Fluconazole-Resistant Isolates of Candida Species
Yali Li, Zhe Wan, Wei Liu, Ruoyu Li
1365–1369
SUSCEPTIBILITY
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FEBRUARY 2015 • VOLUME 59 • NUMBER 2
ANTIVIRAL AGENTS
Impact of Treatment against Hepatitis C Virus on Overall
Survival of Naive Patients with Advanced Liver Disease
Blaise K. Kutala, Jeremie Guedj, Tarik
Asselah, Nathalie Boyer, Feryel Mouri,
Michelle Martinot-Peignoux,
Dominique Valla, Patrick Marcellin,
Xavier Duval
803– 810
A Cell-Based Strategy To Assess Intrinsic Inhibition Efficiencies
of HIV-1 Reverse Transcriptase Inhibitors
Michael E. Abram, Manuel Tsiang,
Kirsten L. White, Christian Callebaut,
Michael D. Miller
838 – 848
Impact of Drug Resistance-Associated Amino Acid Changes in
HIV-1 Subtype C on Susceptibility to Newer Nonnucleoside
Reverse Transcriptase Inhibitors
Adriaan E. Basson, Soo-Yon Rhee,
Chris M. Parry, Ziad El-Khatib, Salome
Charalambous, Tulio De Oliveira,
Deenan Pillay, Christopher Hoffmann,
David Katzenstein, Robert W. Shafer,
Lynn Morris
960 –971
Tenofovir Monotherapy versus Tenofovir plus Lamivudine or
Telbivudine Combination Therapy in Treatment of
Lamivudine-Resistant Chronic Hepatitis B
Yun Bin Lee, Eun Uk Jung, Bo Hyun
Kim, Jeong-Hoon Lee, Hyeki Cho,
Hongkeun Ahn, Won-Mook Choi,
Young Youn Cho, Minjong Lee, JeongJu Yoo, Yuri Cho, Dong Hyeon Lee,
Eun Ju Cho, Su Jong Yu, Sung Jae Park,
Yoon Jun Kim, Joong-Won Park, Youn
Jae Lee, Chang-Min Kim, Jung-Hwan
Yoon, Chung Yong Kim, Hyo-Suk Lee
972–978
In Vitro and In Vivo Antiviral Activity and Resistance Profile of
Ombitasvir, an Inhibitor of Hepatitis C Virus NS5A
Preethi Krishnan, Jill Beyer, Neeta
Mistry, Gennadiy Koev, Thomas
Reisch, David DeGoey, Warren Kati,
Andrew Campbell, Laura Williams,
Wangang Xie, Carolyn Setze,
Akhteruzzaman Molla, Christine
Collins, Tami Pilot-Matias
979 –987
In Vitro and In Vivo Antiviral Activity and Resistance Profile of
the Hepatitis C Virus NS3/4A Protease Inhibitor ABT-450
Tami Pilot-Matias, Rakesh Tripathi,
Daniel Cohen, Isabelle Gaultier,
Tatyana Dekhtyar, Liangjun Lu,
Thomas Reisch, Michelle Irvin, Todd
Hopkins, Ron Pithawalla, Timothy
Middleton, Teresa Ng, Keith McDaniel,
Yat Sun Or, Rajeev Menon, Dale
Kempf, Akhteruzzaman Molla,
Christine Collins
988 –997
Synergistic Effect of Nitazoxanide with Neuraminidase
Inhibitors against Influenza A Viruses In Vitro
Giuseppe Belardo, Orlando Cenciarelli,
Simone La Frazia, Jean Francois
Rossignol, M. Gabriella Santoro
1061–1069
Hydroxylated Tropolones Inhibit Hepatitis B Virus Replication
by Blocking Viral Ribonuclease H Activity
Gaofeng Lu, Elena Lomonosova,
Xiaohong Cheng, Eileen A. Moran,
Marvin J. Meyers, Stuart F. J. Le Grice,
Craig J. Thomas, Jian-kang Jiang,
Christine Meck, Danielle R. Hirsch,
Michael P. D’Erasmo, Duygu M.
Suyabatmaz, Ryan P. Murelli, John E.
Tavis
1070 –1079
Mechanism of Action for Respiratory Syncytial Virus Inhibitor
RSV604
SreeRupa Challa, Andrew D. Scott,
Olga Yuzhakov, Ying Zhou, Choi Lai
Tiong-Yip, Ning Gao, Jason Thresher,
Qin Yu
1080 –1087
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FEBRUARY 2015 • VOLUME 59 • NUMBER 2
Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR
Signaling Modulation for Middle East Respiratory Syndrome
Coronavirus Infection as Identified by Temporal Kinome
Analysis
Jason Kindrachuk, Britini Ork, Brit J.
Hart, Steven Mazur, Michael R.
Holbrook, Matthew B. Frieman, Dawn
Traynor, Reed F. Johnson, Julie Dyall,
Jens H. Kuhn, Gene G. Olinger, Lisa E.
Hensley, Peter B. Jahrling
1088 –1099
Novel Dengue Virus NS2B/NS3 Protease Inhibitors
Hongmei Wu, Stefanie Bock, Mariya
Snitko, Thilo Berger, Thomas Weidner,
Steven Holloway, Manuel Kanitz,
Wibke E. Diederich, Holger Steuber,
Christof Walter, Daniela Hofmann,
Benedikt Weißbrich, Ralf Spannaus,
Eliana G. Acosta, Ralf Bartenschlager,
Bernd Engels, Tanja Schirmeister,
Jochen Bodem
1100 –1109
STING Agonists Induce an Innate Antiviral Immune Response
against Hepatitis B Virus
Fang Guo, Yanxing Han, Xuesen Zhao,
Jianghua Wang, Fei Liu, Chunxiao Xu,
Lai Wei, Jian-Dong Jiang, Timothy M.
Block, Ju-Tao Guo, Jinhong Chang
1273–1281
Efficacy and Safety of Faldaprevir, Deleobuvir, and Ribavirin in
Treatment-Naive Patients with Chronic Hepatitis C Virus
Infection and Advanced Liver Fibrosis or Cirrhosis
Stefan Zeuzem, Vicente Soriano, Tarik
Asselah, Edward J. Gane, Jean-Pierre
Bronowicki, Peter Angus, Ansgar W.
Lohse, Felix Stickel, Beat Müllhaupt,
Stuart Roberts, Marcus Schuchmann,
Michael Manns, Marc Bourlière, Maria
Buti, Jerry O. Stern, John-Paul
Gallivan, Florian Voss, John P. Sabo,
Wulf Böcher, Federico J. Mensa, on
behalf of the SOUND-C2 Study Group
1282–1291
Postexposure Prophylactic Effect of Hepatitis B Virus
(HBV)-Active Antiretroviral Therapy against HBV Infection
Tsunamasa Watanabe, Susumu
Hamada-Tsutsumi, Yoshiyuki
Yokomaku, Junji Imamura, Wataru
Sugiura, Yasuhito Tanaka
1292–1298
EPIDEMIOLOGY AND SURVEILLANCE
Dissemination of NDM Metallo-␤-Lactamase Genes among
Clinical Isolates of Enterobacteriaceae Collected during the
SMART Global Surveillance Study from 2008 to 2012
D. Biedenbach, S. Bouchillon,
M. Hackel, D. Hoban, K. Kazmierczak,
S. Hawser, R. Badal
826 – 830
Temporal and Seasonal Changes of Genetic Polymorphisms
Associated with Altered Drug Susceptibility to Chloroquine,
Lumefantrine, and Quinine in Guinea-Bissau between 2003 and
2012
Irina Tatiana Jovel, Poul-Erik Kofoed,
Lars Rombo, Amabelia Rodrigues,
Johan Ursing
872– 879
Frequent Use of Chlorhexidine-Based Body Wash Associated
with a Reduction in Methicillin-Resistant Staphylococcus aureus
Nasal Colonization among Military Trainees
Eugene V. Millar, Wei-Ju Chen,
Carey D. Schlett, Tianyuan Cui,
Katrina B. Crawford, Jeffrey B. Lanier,
David R. Tribble, Michael W. Ellis
943–949
Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility
in the United States by the Gonococcal Isolate Surveillance
Project, 2005 to 2013
Robert D. Kirkcaldy, Olusegun Soge,
John R. Papp, Edward W. Hook III,
Carlos del Rio, Grace Kubin, Hillard S.
Weinstock
998 –1003
Therapeutic Responses of Plasmodium vivax Malaria to
Chloroquine and Primaquine Treatment in Northeastern
Myanmar
Lili Yuan, Ying Wang, Daniel M.
Parker, Bhavna Gupta, Zhaoqing Yang,
Huaie Liu, Qi Fan, Yaming Cao,
Yuping Xiao, Ming-chieh Lee, Guofa
Zhou, Guiyun Yan, J. Kevin Baird,
Liwang Cui
1230 –1235
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FEBRUARY 2015 • VOLUME 59 • NUMBER 2
Genetic Determinants Involved in p-Aminosalicylic Acid
Resistance in Clinical Isolates from Tuberculosis Patients in
Northern China from 2006 to 2012
Xiaobing Zhang, Liguo Liu, Yan Zhang,
Guangming Dai, Hairong Huang, Qi
Jin
1320 –1324
Complete Nucleotide Sequence of the IncN Plasmid Encoding
IMP-6 and CTX-M-2 from Emerging Carbapenem-Resistant
Enterobacteriaceae in Japan
Shizuo Kayama, Norifumi Shigemoto,
Ryuichi Kuwahara, Kenshiro Oshima,
Hideki Hirakawa, Junzo Hisatsune,
Thomas Jové, Hisaaki Nishio,
Katsutoshi Yamasaki, Yasunao Wada,
Takeshi Ueshimo, Tetsuya Miura,
Taijiro Sueda, Makoto Onodera,
Michiya Yokozaki, Masahira Hattori,
Hiroki Ohge, Motoyuki Sugai
1356 –1359
EXPERIMENTAL THERAPEUTICS
Pharmacodynamics of Imipenem in Combination with
␤-Lactamase Inhibitor MK7655 in a Murine Thigh Model
Eleftheria Mavridou, Ria J. B. Melchers,
Anita C. H. A. M. van Mil, E. Mangin,
Mary R. Motyl, Johan W. Mouton
790 –795
Daptomycin plus Fosfomycin, a Synergistic Combination in
Experimental Implant-Associated Osteomyelitis Due to
Methicillin-Resistant Staphylococcus aureus in Rats
Tilman Lingscheid, Wolfgang Poeppl,
Dominik Bernitzky, Luzia Veletzky,
Manuel Kussmann, Roberto
Plasenzotti, Heinz Burgmann
859 – 863
The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active
against Mycobacterium tuberculosis In Vivo
Wei Gao, Jin-Yong Kim, Jeffrey R.
Anderson, Tatos Akopian, Seungpyo
Hong, Ying-Yu Jin, Olga Kandror,
Jong-Woo Kim, In-Ae Lee, Sun-Young
Lee, James B. McAlpine, Surafel
Mulugeta, Suhair Sunoqrot, Yuehong
Wang, Seung-Hwan Yang, Tae-Mi
Yoon, Alfred L. Goldberg, Guido F.
Pauli, Joo-Won Suh, Scott G.
Franzblau, Sanghyun Cho
880 – 889
A New Nonpolar N-Hydroxy Imidazoline Lead Compound
with Improved Activity in a Murine Model of Late-Stage
Trypanosoma brucei brucei Infection Is Not Cross-Resistant
with Diamidines
Carlos H. Ríos Martínez, Florence
Miller, Kayathiri Ganeshamoorthy,
Fabienne Glacial, Marcel Kaiser,
Harry P. de Koning, Anthonius A. Eze,
Laura Lagartera, Tomás Herraiz,
Christophe Dardonville
890 –904
Antisense Growth Inhibition of Methicillin-Resistant
Staphylococcus aureus by Locked Nucleic Acid Conjugated
with Cell-Penetrating Peptide as a Novel FtsZ Inhibitor
Jingru Meng, Fei Da, Xue Ma, Ning
Wang, Yukun Wang, Huinan Zhang,
Mingkai Li, Ying Zhou, Xiaoyan Xue,
Zheng Hou, Min Jia, Xiaoxing Luo
914 –922
Influence of Vancomycin Infusion Methods on Endothelial
Cell Toxicity
Maryline Drouet, Feng Chai, Christine
Barthélémy, Gilles Lebuffe, Bertrand
Debaene, Bertrand Décaudin, Pascal
Odou
930 –934
Histone Methyltransferase Inhibitors Are Orally Bioavailable,
Fast-Acting Molecules with Activity against Different Species
Causing Malaria in Humans
Nicholas A. Malmquist, Sandeep
Sundriyal, Joachim Caron, Patty Chen,
Benoit Witkowski, Didier Menard,
Rossarin Suwanarusk, Laurent Renia,
Francois Nosten, María Belén JiménezDíaz, Iñigo Angulo-Barturen, María
Santos Martínez, Santiago Ferrer,
Laura M. Sanz, Francisco-Javier Gamo,
Sergio Wittlin, Sandra Duffy, Vicky M.
Avery, Andrea Ruecker, Michael J.
Delves, Robert E. Sinden, Matthew J.
Fuchter, Artur Scherf
950 –959
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FEBRUARY 2015 • VOLUME 59 • NUMBER 2
In Vitro Resistance Studies with Bacteria That Exhibit Low
Mutation Frequencies: Prediction of “Antimutant” Linezolid
Concentrations Using a Mixed Inoculum Containing both
Susceptible and Resistant Staphylococcus aureus
Alexander A. Firsov, Maria V.
Golikova, Elena N. Strukova, Yury A.
Portnoy, Andrey V. Romanov,
Mikhail V. Edelstein, Stephen H.
Zinner
1014 –1019
Identification of Capsular Types in Carbapenem-Resistant
Klebsiella pneumoniae Strains by wzc Sequencing and
Implications for Capsule Depolymerase Treatment
Yi-Jiun Pan, Tzu-Lung Lin, Yi-Tsung
Lin, Po-An Su, Chun-Tang Chen,
Pei-Fang Hsieh, Chun-Ru Hsu, ChingChing Chen, Yu-Chia Hsieh, Jin-Town
Wang
1038 –1047
Bacteriophage-Mediated Control of a Two-Species Biofilm
Formed by Microorganisms Causing Catheter-Associated
Urinary Tract Infections in an In Vitro Urinary Catheter Model
Susan M. Lehman, Rodney M. Donlan
1127–1137
Microbiome Changes in Healthy Volunteers Treated with
GSK1322322, a Novel Antibiotic Targeting Bacterial Peptide
Deformylase
Seda Arat, Aaron Spivak, Stephanie
Van Horn, Elizabeth Thomas,
Christopher Traini, Ganesh Sathe,
George P. Livi, Karen Ingraham, Lori
Jones, Kelly Aubart, David J. Holmes,
Odin Naderer, James R. Brown
1182–1192
Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone
Analogs and KAE609 in a Murine Malaria Model
Suresh B. Lakshminarayana, Céline
Freymond, Christoph Fischli, Jing Yu,
Sebastian Weber, Anne Goh,
Bryan K. S. Yeung, Paul C. Ho,
Véronique Dartois, Thierry T. Diagana,
Matthias Rottmann, Francesca Blasco
1200 –1210
The Novel Immunotherapeutic Oligodeoxynucleotide IMT504
Protects Neutropenic Animals from Fatal Pseudomonas
aeruginosa Bacteremia and Sepsis
Abdullah Chahin, Steven M. Opal,
Jorge Zorzopulos, David V. Jobes,
Yazan Migdady, Michelle Yamamoto,
Nicholas Parejo, John E. Palardy,
David L. Horn
1225–1229
Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem,
an Orally Bioavailable ␤-Lactam Antibiotic
Neeraj Dhar, Vincent Dubée, Lluis
Ballell, Guillaume Cuinet, JeanEmmanuel Hugonnet, François
Signorino-Gelo, David Barros, Michel
Arthur, John D. McKinney
1308 –1319
Engineered Cationic Antimicrobial Peptides To Overcome
Multidrug Resistance by ESKAPE Pathogens
Berthony Deslouches, Jonathan D.
Steckbeck, Jodi K. Craigo, Yohei Doi,
Jane L. Burns, Ronald C. Montelaro
1329 –1333
The Novel Arylamidine T-2307 Maintains In Vitro and In Vivo
Activity against Echinocandin-Resistant Candida albicans
Nathan P. Wiederhold, Laura K.
Najvar, Annette W. Fothergill, Rosie
Bocanegra, Marcos Olivo, Dora I.
McCarthy, William R. Kirkpatrick,
Yoshiko Fukuda, Junichi Mitsuyama,
Thomas F. Patterson
1341–1343
Systemic Antifungal Prescribing in Neonates and Children:
Outcomes from the Antibiotic Resistance and Prescribing in
European Children (ARPEC) Study
J. M. Lestner, A. Versporten,
K. Doerholt, A. Warris, E. Roilides,
M. Sharland, J. Bielicki, H. Goossens,
ARPEC Project Group
782–789
Inappropriate Continued Empirical Vancomycin Use in a
Hospital with a High Prevalence of Methicillin-Resistant
Staphylococcus aureus
Nak-Hyun Kim, Hei Lim Koo, Pyeong
Gyun Choe, Shinhye Cheon, Moon Suk
Kim, Myung Jin Lee, Young Hee Jung,
Wan Beom Park, Kyoung-Ho Song,
Eu Suk Kim, Ji Hwan Bang, Hong Bin
Kim, Sang Won Park, Nam Joong Kim,
Myoung-don Oh, Eui Chong Kim
811– 817
CLINICAL THERAPEUTICS
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FEBRUARY 2015 • VOLUME 59 • NUMBER 2
Prophylaxis with Teicoplanin and Cefuroxime Reduces the Rate
of Prosthetic Joint Infection after Primary Arthroplasty
Eduard Tornero, Sebastian GarcíaRamiro, Juan C. Martínez-Pastor,
Guillem Bori, Jordi Bosch, Laura
Morata, Marta Sala, Misericordia
Basora, Josep Mensa, Alex Soriano
831– 837
Analysis of the Phase 3 ESTABLISH Trials of Tedizolid versus
Linezolid in Acute Bacterial Skin and Skin Structure Infections
Andrew F. Shorr, Thomas P. Lodise,
G. Ralph Corey, Carisa De Anda,
Edward Fang, Anita F. Das, Philippe
Prokocimer
864 – 871
Assessment of Time to Clinical Response, a Proxy for Discharge
Readiness, among Hospitalized Patients with CommunityAcquired Pneumonia Who Received either Ceftaroline Fosamil
or Ceftriaxone in Two Phase III FOCUS Trials
Thomas P. Lodise, Antonio R. Anzueto,
David J. Weber, Andrew F. Shorr, Min
Yang, Alexander Smith, Qi Zhao,
Xingyue Huang, Thomas M. File
1119 –1126
Limited-Sampling Strategies for Anidulafungin in Critically Ill
Patients
Marjolijn J. P. van Wanrooy,
Johannes H. Proost, Michael G. G.
Rodgers, Jan G. Zijlstra, Donald R. A.
Uges, Jos G. W. Kosterink, Tjip S.
van der Werf, Jan-Willem C. Alffenaar
1177–1181
Pharmacokinetics and Safety Study of Posaconazole Intravenous
Solution Administered Peripherally to Healthy Subjects
Wendy M. Kersemaekers, Thijs
van Iersel, Ulla Nassander, Edward
O’Mara, Hetty Waskin, Maria Caceres,
Marlou L. P. S. van Iersel
1246 –1251
Testing Tuberculosis Drug Efficacy in a Zebrafish HighThroughput Translational Medicine Screen
Anita Ordas, Robert-Jan Raterink,
Fraser Cunningham, Hans J. Jansen,
Malgorzata I. Wiweger, Susanne JongRaadsen, Sabine Bos, Robert H. Bates,
David Barros, Annemarie H. Meijer,
Rob J. Vreeken, Lluís Ballell-Pages,
Ron P. Dirks, Thomas Hankemeier,
Herman P. Spaink
753–762
Population Pharmacokinetics of Micafungin and Its Metabolites
M1 and M5 in Children and Adolescents
William W. Hope, Atsunori Kaibara,
Michael Roy, Antonio Arrieta, Nkechi
Azie, Laura L. Kovanda, Daniel K.
Benjamin, Jr.
905–913
First-in-Humans Study of the Safety, Tolerability, and
Pharmacokinetics of ACT-451840, a New Chemical Entity with
Antimalarial Activity
Shirin Bruderer, Noémie Hurst, Ruben
de Kanter, Tommaso Miraval, Thomas
Pfeifer, Yves Donazzolo, Jasper
Dingemanse
935–942
Pharmacokinetics and Safety of Voriconazole Intravenous-toOral Switch Regimens in Immunocompromised Japanese
Pediatric Patients
Masaaki Mori, Ryoji Kobayashi,
Koji Kato, Naoko Maeda, Keitaro
Fukushima, Hiroaki Goto, Masami
Inoue, Chieko Muto, Akifumi
Okayama, Kenichi Watanabe, Ping Liu
1004 –1013
Added Benefit of Raxibacumab to Antibiotic Treatment of
Inhalational Anthrax
Thi-Sau Migone, Sally Bolmer, John
Zhong, Al Corey, Daphne Vasconcelos,
Matthew Buccellato, Gabriel Meister
1145–1151
Pharmacokinetics of First-Line Antituberculosis Drugs in
HIV-Infected Children with Tuberculosis Treated with
Intermittent Regimens in India
Geetha Ramachandran, A. K. Hemanth
Kumar, P. K. Bhavani, T. Kannan,
S. Ramesh Kumar, N. Poorana
Gangadevi, V. V. Banurekha, L. Sekar,
N. Ravichandran, G. Mathevan,
G. N. Sanjeeva, Rajeshwar Dayal,
Soumya Swaminathan
1162–1167
PHARMACOLOGY
Continued on following page
Continued from preceding page
FEBRUARY 2015 • VOLUME 59 • NUMBER 2
Evaluation of the Pharmacokinetic Interaction between
Repeated Doses of Rifapentine or Rifampin and a Single
Dose of Bedaquiline in Healthy Adult Subjects
Helen Winter, Erica Egizi, Stephen
Murray, Ngozi Erondu, Ann Ginsberg,
Doris J. Rouse, Diana SeverynseStevens, Elliott Pauli
1219 –1224
In Vivo Pharmacokinetics and Pharmacodynamics of the
Lantibiotic NAI-107 in a Neutropenic Murine Thigh Infection
Model
Alexander J. Lepak, Karen Marchillo,
William A. Craig, David R. Andes
1258 –1264
Pharmacodynamic Target Evaluation of a Novel Oral Glucan
Synthase Inhibitor, SCY-078 (MK-3118), Using an In Vivo
Murine Invasive Candidiasis Model
Alexander J. Lepak, Karen Marchillo,
David R. Andes
1265–1272
Enantiospecific Reassessment of the Pharmacokinetics and
Pharmacodynamics of Oral Eflornithine against Late-Stage
Trypanosoma brucei gambiense Sleeping Sickness
R. Jansson-Löfmark, K. Na-Bangchang,
S. Björkman, F. Doua, M. Ashton
1299 –1307
Evolution of Staphylococcus aureus under Vancomycin Selective
Pressure: the Role of the Small-Colony Variant Phenotype
Justin R. Lenhard, Christof von Eiff,
Irene S. Hong, Patricia N. Holden,
Michael D. Bear, Amy Suen, Zackery P.
Bulman, Brian T. Tsuji
1347–1351
LETTERS TO THE EDITOR
In Vitro Ceftriaxone Susceptibility in Methicillin-Susceptible
Staphylococcus aureus
Kady Phe, Dorothy Dao, Hannah R.
Palmer, Vincent H. Tam
1370
Detection of CTX-M-64 in Escherichia coli Isolates from Human
Patients in China
Dan-xia Gu, Tao Yu, Yang Wang, Rong
Zhang
1371–1372
In Vitro Interaction of Currently Used Azoles with Terbinafine
against Madurella mycetomatis
Sarah Abdalla Ahmed, Wendy Kloezen,
Ahmed H. Fahal, G. Sybren de Hoog,
Wendy W. J. van de Sande
1373–1374
Detection of QnrB54 and Its Novel Genetic Context in
Citrobacter freundii Isolated from a Clinical Case
Maria Jorge Campos, Gonzalo Palomo,
Lorena Hormeño, Américo Patrocínio
Rodrigues, Rosario Sánchez-Benito,
Segundo Píriz, Alberto Quesada
1375–1376
Penicillinase-Encoding Gene blaTEM-1 May Be Plasmid Borne or
Chromosomally Located in Kingella kingae Species
Romain Basmaci, Philippe Bidet,
Christelle Jost, Pablo Yagupsky,
Stéphane Bonacorsi
1377–1378
Imipenem-Susceptible, Meropenem-Resistant Klebsiella
pneumoniae Producing OXA-181 in Japan
Shizuo Kayama, Yumiko Koba,
Norifumi Shigemoto, Ryuichi
Kuwahara, Tomoko Kakuhama,
Kimie Kimura, Junzo Hisatsune,
Makoto Onodera, Michiya Yokozaki,
Hiroki Ohge, Motoyuki Sugai
1379 –1380
First Detection of Conjugative Plasmid-Borne Fosfomycin
Resistance Gene fosA3 in Salmonella Isolates of Food Origin
Dachuan Lin, Sheng Chen
1381–1383
Breakpoints and Drug Exposure Are Inevitably Closely Linked
J. W. C. Alffenaar, O. W. Akkerman,
M. S. Bolhuis, M. J. Boeree,
W. C. M. de Lange, T. S. van der Werf
1384
Reply to “Breakpoints and Drug Exposure Are Inevitably
Closely Linked”
Tawanda Gumbo, Jotam G.
Pasipanodya, Peter Wash, André
Burger, Helen McIlleron
1385
The Brain, Amphotericin B, and P-Glycoprotein
David A. Stevens, Karl V. Clemons,
Marife Martinez, Vicky Chen
1386
Reply to “The Brain, Amphotericin B, and P-Glycoprotein”
Ji-Qin Wu, Kun Shao, Chen Jiang,
Li-Ping Zhu
1387