Sigue el periódico de la comunidad del medicamento en
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Evolución de los impagos a farmacias
Aragón
24,5
0
Cataluña
226
-24,5
114,9
-111
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C. Valenciana
98,6
98,6
0
Deuda aproximada en diciembre
de 2015 (millones de euros)
Deuda aproximada en diciembre
de 2016 (millones de euros)
Diferencia entre diciembre
de 2015 y diciembre de 2016
* En Baleares, desde octubre los pagos tienen un retraso en torno a seis días.
Fuente: Elaboración propia.
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Tiempos para medir la efectividad relativa y para los criterios finales de reembolso
Canakinumab
Fingolimod
Bromuro de
glicopirronio
Everolimus
20
15
10
Tiempo para evaluar la efectividad relativa (REA)
La diversidad de los datos requeridos:
el ejemplo de los antidiabéticos
República Checa
Polonia
España
Italia
Francia
Reino Unido
Hungría
Países Bajos
Polonia
República Checa
Italia
Países
Tiempo para otras actividades
España
Suecia
Francia
Reino Unido
República Checa
Países Bajos
España
Italia
Francia
Reino Unido
Suecia
Hungría
Países Bajos
Polonia
República Checa
0
España
5
Alemania
Francia
Italia
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Los diferentes calendarios de la evaluación en Europa
Reino Unido
.BESJE
Tiempo en meses
$"3-04#30%3¶(6&;
Requerimientos temporales de la UE en cuestión de acceso
Distintas metodologías, resultados divergentes.
Profundizando en los antidiabéticos
Forxiga
(dapaglifozina)
UE
Francia
Reino Unido
Francia
Escocia
Alemania
Alemania
Invokana
(canaglifozin)
Jardiance
(empaglifozina)
Reino Unido
Italia
Países Bajos
Escocia
&MDBNJOPIBTUBBIPSB
España
Suecia
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Suecia
Diabetes tipo 2: evaluación HTA
Datos de seguridad
Comportamiento del medicamento en la vida real
Resultado positivos
Calidad de vida
Datos de los ensayos clínicos
Resultado positivos con limitaciones
Evidencia económica
Comparaciones indirectas
Resultado negativos
Otras fuentes
Revisiones sistemáticas/Meta-análisis
Bajo revisión
Fuente: Comisión Europea.
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El futuro de la evaluación conjunta en la UE
Características básicas
Opción 1
Status quo.
Cooperación
voluntaria en HTA
hasta 2020
Opción 2
Cooperación
voluntaria a largo
plazo en HTA (más
allá de 2020)
Opción 3
Cooperación para
recopilar, compartir
y usar herramientas
y datos comunes
Opción 4
Cooperación en
la producción
de informes REA
conjuntos
Regulatorias
No legislativa
No legislativa
Legislativa
Legislativa
Legislativa
Obligatoria para las
herramientas.
Obligatoria para las
herramientas.
Voluntaria para HTA
Obligatoria o
voluntaria para la HTA
Obligatoria o
voluntaria para la HTA
Obligatoria para las
herramientas.
Opción 5
Cooperación en
la producción
de informes HTA
conjuntos
Participación de la industria y de los
cuerpos de HTA
Voluntaria
Adopción de resultados conjuntos
Voluntaria
Voluntaria
Obligatoria para las
herramientas
Obligatoria para las
herramientas y los
informes REA
Obligatoria
Financiación
Presupuestos
europeos, sobre
todo
Presupuestos
europeos, sobre
todo
Financiación mixta:
UE + estados +
industria
Financiación mixta:
UE + estados +
industria
Financiación mixta:
UE + estados +
industria
Hasta 2020
A largo plazo
A largo plazo
A largo plazo
A largo plazo
(✓)
(✓)
(✓)
(✓)
✓
(✓)
(✓)
✓
✓
✓
(✓)
✓
Voluntaria
Resultados esperables
(✓)
(✓)
(✓)
(✓)
1. Herramientas/modelos conjuntos
2. Informes REA conjuntos
3. Informes HTA conjuntos
4. Diálogo temprano
(✓)
Consecución parcial
✓
✓
✓
✓
✓
Consecución completa
El Global
Fuente: Comisión Europea.
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Evolución de los impagos a farmacias
Aragón
24,5
0
Cataluña
226
-24,5
114,9
-111
C. Valenciana
98,6
98,6
0
Deuda aproximada en diciembre
de 2015 (millones de euros)
Deuda aproximada en diciembre
de 2016 (millones de euros)
Diferencia entre diciembre
de 2015 y diciembre de 2016
* En Baleares, desde octubre los pagos tienen un retraso en torno a seis días.
Fuente: Elaboración propia.
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Si ves números por todos lados, es
hora de informarte acerca de nuestras
condiciones comerciales y servicio
hecho a medida para tu farmacia.
EL ALIADO DE LA FARMACIA EN
MEDICAMENTOS GENÉRICOS
www.krka.com.es
Vivir una vida sana.
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UPTEFDÃODFSFTEFMBTBOHSFJODMVJEPTMB
MFVDFNJBMJOGPDÎUJDBDSÓOJDBFMMJOGPNB
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."35"3*&4(0
Gasto farmacéutico global 2007-2021
10%
1.600
1.400
8%
1.200
1.000
6%
800
4%
600
400
2%
200
0
0%
2007
2008
2009
2010
2011
2012
2013
Gasto
2014
2015
2016
2017
.BESJE
6OBÒPNÃTMBJOEVTUSJBGBSNBDÊVUJDBFT
FM TFHNFOUP MBCPSBM EF MB FDPOPNÎB
FTQBÒPMB RVF PCUJFOF QSPQPSDJPOBM
NFOUFMBNFKPSDBMJGJDBDJÓOFOSFMBDJÓOB
MBSFUSJCVDJÓOGJOBODJFSBTFHÙOMPTEBUPT
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3FUSJCVUJWPEF.FSDBEPFMBCPSBEPQPS
8JMMJT5PXFST8BUTPO&ODPODSFUPMB
QSPQPSDJÓO QPS MB DVBM MB JOEVTUSJB
GBSNBDÊVUJDBTFTJUÙBFOFMFOUPSOPEFM
2018
2019
2020
2021
Crecimiento
Medicamentos en últimas fases de investigación 2016
Porcentaje del pipeline
Fase II - Registro
100%
5%
6%
80%
31%
6%
N=1981
30%
35%
20%
27%
0%
Oncología
Atritis / Dolor
60%
40%
8%
12%
N= 259
5%
5%
6%
5%
5%
8%
12%
6%
7%
10%
10%
10%
6%
Sistema nervioso central
Sistema inmune
Anti-infeccioso y antivirales
Genito-urinario y hormonas
Cardiovascular
28%
Otros
15%
PreReg / Reg
Fase II / Fase III
Fuente: QuintilesIMS.
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Evolución del mercado farmacéutico global hasta 2021
Gasto en miles de millones de dólares
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JOEVTUSJBGBSNBDÊVUJDBSFUBJMZEFMTFDUPS
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.BESJE
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VO BDVFSEP B NFEJEB QBSB (SBO
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FTPFTUBNPTUSBCBKBOEPDPOFM(PCJFSOP
QBSBDPOTFHVJSCFOFGJDJPTDPOMBGJSNBEF
VO BDVFSEPu &O FTUF TFOUJEP IB
BQVOUBEPiMBBMJOFBDJÓOEFM3FJOP6OJEP
ZMBDPPQFSBDJÓODPOFMNBSDPSFHVMBUP
SJPEFMB6&FONBUFSJBEFNFEJDBNFO
UPTQVFEFTFSVOPCKFUJWPDPNÙOQBSB
OVFTUSP(PCJFSOPZQBSBMPTFTUBEPT
NJFNCSPZEFCFTFSVOPCKFUJWPQSJPSJ
UBSJPFOMBTOFHPDJBDJPOFTEFM#SFYJUu
1BSB MB QBUSPOBM MB SPCVTUF[ Z MB
BMJOFBDJÓOJOUFSOBDJPOBMEFMBSFHVMBDJÓO
EFMPTNFEJDBNFOUPTIBOTJEPFTFODJB
MFTQBSBQSPUFHFSZNFKPSBSMBTBMVEEF
MPTQBDJFOUFTIBHBSBOUJ[BEPMBFGJDBDJB
ZMBTFHVSJEBEMPTBWBODFTEFMBJOOPWB
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Mano
a
mano
POR UN MUNDO MEJOR
Éste le recetó
el medicamento
Éste
lo dispensó en la
farmacia y le indicó
cómo reciclarlo
Éste, en la
industria, investigó
la cura y un envase
ecológico
Éste se
puso malito
Y éste,
como tú, lo recicló
ó
en el Punto SIGRE
E
El compromiso de la industria farmacéutica, las empresas de distribución
y las farmacias, está contribuyendo a que los envases
de medicamentos sean más ecológicos y a que su reciclado forme parte
de los hábitos medioambientales de los hogares españoles.
Por ello, las autoridades sanitarias y medioambientales
recomiendan llevar al Punto SIGRE de la farmacia:
LOS ENVASES VACÍOS
LOS RESTOS DE MEDICAMENTOS
LOS MEDICAMENTOS CADUCADOS
Con la colaboración de todos, lograremos un mundo mejor
UNA INICIATIVA DE LA INDUSTRIA FARMACÉUTICAEN COLABORACIÓN CON LA DISTRIBUCIÓN Y LAS FARMACIAS
www.sigre.es
15
AÑOS
."35"3*&4(0
CONTIGO
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Exclusivo NetSalud
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Sanofi en cifras
Euros
VALOR DE LAS ACCIONES
• Capitalización bursátil
• Final de año
• Más alta
• Más baja
• Dividendos por acción
POR PRODUCTOS
• Lantus
• Plavix
• Lovenox
• Aprovel/CoAprovel
2015
2014
33.770
millones
2014
96.170 millones
73,3
88,9
71,2
2,85
2015
2014
6.390 millones
1.929 millones
1.719 millones
762 millones
6.344 millones
1.862 millones
1.699 millones
727 millones
INVERSIÓN EN I+D
% DE LAS VENTAS
5.259 millones
4.770 millones
14,2%
14,4%
VENTAS POR ÁREA GEOGRÁFICA
VENTAS
32.951
millones
2015
101.149 millones
78,6
100,6
74,3
2,93
SANOFI (2015)
37.057
millones
13.406 millones
EEUU
8.026 millones
Europa Occidental
3.611 millones
Otros países
2013
2014
12.014 millones
Mercados emergentes
2015
Fuente: elaboración propia a partir de datos de la compañía
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Sanofi
Euros
90
85
80
75
70
65
€
60
Dic
Feb
Abr
Jun
Ago Oct
Dic
2015
2016
2016
2016
2016
2016
2016
Fuente: elaboración propia.
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r*OEVTUSJB&-(-0#"-BMEFEJDJFNCSFEF
Índice global. Evolución en los últimos doce meses
170
145
120
Índice Global: -1,55
95
BE 500
-2,57
IBEX 35
-4,05
70
Dic
2015
Ene
2016
Feb
2016
Mar
2016
Abr
2016
May
2016
Jun
2016
Jul
2016
Ago
2016
Sep
2016
Oct
2016
Nov
2016
9 diciembre 2016
El Índice Global, referencia en bolsa del sector farmacéutico, está integrado por 29 valores internacionales. La ponderación de cada uno está en función de su capitalización bursatil. El valor de este
índice el 1 de enero del 2000, se tomó como base
100, de manera que su valor actual indica la revalorización o depreciación que dicho índice acumula
respecto a la base. Las variaciones de cada uno de
los índices se calculan respecto a la misma frecha
del mes anterior, mientras que las variaciones recogidas en el texto de la noticia hacen referencia
a la semana.
Para conocer los valores del Índice Global, consulte:
www.elgobal.net
Fuente: elaboración propia.
El Global
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Plazos de remisión de candidaturas y cronograma de evaluación
octubre
noviembre
2017
25-28
octubre
18
23-26
27-30
2017
2017
2017
2017
9
16
22
septiembre
28
8
octubre
6
octubre
octubre
26
31
30
diciembre
8
20
septiembre
2017
1
14
julio
2017
julio
2017
6
2017
junio
noviembre
noviembre
20
junio
14
octubre
2017
29-1
septiembre
20
junio
septiembre
2017
2017
septiembre
18
12
noviembre
2017
ago-sep
23
12
2017
3-6
2017
2017
agosto
5
septiembre
julio
28
mayo
2017
junio
6-9
2017
2017
31
21
mayo
julio
junio
abril
mayo
2017
mayo
2-5
12
2017
2017
26
abril
9
diciembre
2017
mayo
2017
abril
3-6
2017
2017
29
23
14
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enero
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11
19
25
2018
abril
6
17
2017
6-9
marzo
2017
abril
2017
2017
marzo
9
marzo
2017
marzo
1
2017
6-9
2017
2017
2017
marzo
marzo
2017
febrero
1
2017
2017
2017
2017
febrero
9
2017
23
9-12
2018
11ª
17
4
2017
10ª
febrero
2018
9ª
febrero
2017
8ª
febrero
2017
7ª
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2017
6ª
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2017
5ª
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3ª
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2ª
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1ª
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Presente y futuro del esquema PRIME
2017
.BESJE
convocatoria
$"3-04#30%3¶(6&;
*Grupo de Trabajo de Asesoramiento Científico de la EMA. **Comité de Terapias Avanzadas. ***Sólo en
caso de medicamentos de terapia avanzada. ****Comité de Medicamentos de Uso Humano de la EMA.
Repaso de la actividad de PRIME hasta el 21 de septiembre de 2016
4
Aprobados
14
Rechazados
46
Fuera del ámbito
Por area terapéutica
Pymes
7
27
Otros
7
19
Fuente: Agencia Europea del Medicamento.
El Global
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